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公开(公告)号:US06713453B2
公开(公告)日:2004-03-30
申请号:US09963156
申请日:2001-09-25
申请人: Heinz Redl , Walter Fuerst , Rudolf Kneidinger , Sam L. Helgerson , Douglas Looker , Elisabeth M. Inman , Jane P. Richards , Catalina Wong
发明人: Heinz Redl , Walter Fuerst , Rudolf Kneidinger , Sam L. Helgerson , Douglas Looker , Elisabeth M. Inman , Jane P. Richards , Catalina Wong
IPC分类号: A61K3818
CPC分类号: C07K14/745 , A61K38/00 , A61K47/64 , A61K47/6435 , A61K47/665 , B82Y5/00
摘要: A fibrin/fibrinogen binding conjugate for forming a depot for the sustained release of a pharmaceutically active substance from a fibrin clot. The conjugate comprises a fibrin/fibrinogen binding moiety bound to a pharmaceutically active substance either directly or via an intervening substance capturing moiety such as an antibody. The conjugate can also be a recombinant fusion protein comprising a fibrin/fibrinogen binding moiety such as VEGF165 C-terminal domain fused to a wound-healing substance such as leptin.
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公开(公告)号:US07091325B2
公开(公告)日:2006-08-15
申请号:US10749832
申请日:2003-12-30
申请人: Heinz Redl , Walter Fuerst , Rudolf Kneidinger , Sam L. Helgerson , Douglas Looker , Elisabeth M. Inman , Jane P. Richards , Catalina Wong
发明人: Heinz Redl , Walter Fuerst , Rudolf Kneidinger , Sam L. Helgerson , Douglas Looker , Elisabeth M. Inman , Jane P. Richards , Catalina Wong
IPC分类号: A61K31/7088 , A61K38/17 , A61K39/395 , C07H21/00 , C07K14/435
CPC分类号: C07K14/745 , A61K38/00 , A61K47/64 , A61K47/6435 , A61K47/665 , B82Y5/00
摘要: A fibrin/fibrinogen binding conjugate for forming a depot for the sustained release of a pharmaceutically active substance from a fibrin clot. The conjugate comprises a fibrin/fibrinogen binding moiety bound to a pharmaceutically active substance either directly or via an intervening substance capturing moiety such as an antibody. The conjugate can also be a recombinant fusion protein comprising a fibrin/fibrinogen binding moiety such as VEGF165 C-terminal domain fused to a wound-healing substance such as leptin.
摘要翻译: 用于形成用于从血纤维蛋白凝块中持续释放药物活性物质的贮库的纤维蛋白/纤维蛋白原结合缀合物。 缀合物包含直接或通过介入物质捕获部分如抗体与药物活性物质结合的纤维蛋白/纤维蛋白原结合部分。 缀合物还可以是包含纤维蛋白/纤维蛋白原结合部分的重组融合蛋白,例如融合到伤口愈合物质如瘦蛋白的VEGF 165 C末端结构域。
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