公开(公告)号：US06919086B1

公开(公告)日：2005-07-19

申请号：US09381903

申请日：1998-03-16

申请人： Helga Kahlert ,  Hans-Thomas Stüwe ,  Helmut Fiebig ,  Oliver Cromwell ,  Wolf-Meinhard Becker ,  Albrecht Bufe ,  Gabriele Schramm ,  Lothar Jäger ,  Wolf-Dieter Müller

发明人： Helga Kahlert ,  Hans-Thomas Stüwe ,  Helmut Fiebig ,  Oliver Cromwell ,  Wolf-Meinhard Becker ,  Albrecht Bufe ,  Gabriele Schramm ,  Lothar Jäger ,  Wolf-Dieter Müller

IPC分类号： C12N15/09 ,  A61K36/899 ,  A61K38/00 ,  A61K39/00 ,  A61P37/08 ,  C07K14/415 ,  C12Q1/68 ,  A61K39/36

CPC分类号： C07K14/415 ,  A61K38/00

摘要： The invention relates to modified recombinant allergen mutants which can be obtained from recombinant allergens which are derived from allergens which can be obtained by extraction from natural raw materials such as pollen of the species Phleum pratense. While these modified recombinant allergens stimulate lymphocytes from patients who are allergic to pollent to proliferate and synthesize cytokines, they exhibit a markedly diminished ability to bind to the IgE antibodies which are present in the serum of the T lymphocyte donors and to grass pollen allergen-specific IgEs and can therefore be used for a specific, made-to-release allergy therapy.

摘要翻译： 本发明涉及可从源自变应原的重组变应原获得的修饰的重组变应原突变体，其可以通过从诸如Phleum pratense种的花粉等天然原料中提取而获得。 虽然这些修饰的重组变应原刺激对花粉过敏的患者的淋巴细胞增殖和合成细胞因子，但是它们显示出与T淋巴细胞供体的血清中存在的IgE抗体和草花粉过敏原特异性结合的显着降低的能力 IgE，因此可用于特定的，即时释放的过敏疗法。