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公开(公告)号：US20160289621A1
公开(公告)日：2016-10-06
申请号：US15142856
申请日：2016-04-29
发明人： Mason Oelschlager , Luke Cizek , Mason McCarty , Justin Hayden , Candyce Bair
CPC分类号： C12M21/02 , C12M23/14 , C12M23/22 , C12M23/26 , C12M23/34 , C12M23/48 , C12M27/04 , C12M29/04 , C12M29/06 , C12M31/00 , C12M37/00 , C12M41/22 , C12M41/36 , C12M41/40 , C12N1/12
摘要： Some embodiments include a method. The method can include: providing one or more bioreactor walls of a bioreactor, the one or more bioreactor walls having at least one bioreactor wall material; providing one or more bioreactor fittings of the bioreactor, the one or more bioreactor fittings having at least one gas delivery fitting; providing one or more gas delivery devices of the bioreactor; providing one or more flexible tubes of the bioreactor, the one or more flexible tubes having at least one gas delivery tube; providing at least one parameter sensing device; and assembling the bioreactor. Other embodiments of related systems and methods are also disclosed.
摘要翻译： 一些实施例包括一种方法。 该方法可以包括：提供生物反应器的一个或多个生物反应器壁，所述一个或多个生物反应器壁具有至少一个生物反应器壁材料; 提供所述生物反应器的一个或多个生物反应器配件，所述一个或多个生物反应器配件具有至少一个气体输送配件; 提供生物反应器的一个或多个气体输送装置; 提供所述生物反应器的一个或多个柔性管，所述一个或多个柔性管具有至少一个气体输送管; 提供至少一个参数感测装置; 并组装生物反应器。 还公开了相关系统和方法的其它实施例。
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公开(公告)号：US20160289620A1
公开(公告)日：2016-10-06
申请号：US15142811
申请日：2016-04-29
发明人： Richard Mazur , Luke Cizek , Mason Oelschlager , Mason McCarty , Minh Duc Tram , Justin Hayden , Candyce Bair
CPC分类号： C12M21/02 , C12M23/14 , C12M23/26 , C12M23/34 , C12M23/40 , C12M23/48 , C12M27/04 , C12M29/04 , C12M29/06 , C12M31/00 , C12M37/00 , C12M41/22 , C12M41/36 , C12M41/40
摘要： Some embodiments include a system having a support structure configured to mechanically support a first bioreactor. The support structure can have a first frame and a second frame together being configured to mechanically support the first bioreactor in interposition between the first frame and the second frame. The first frame can maintain a first set point temperature of the first bioreactor through an exchange of thermal energy between the first frame and the first bioreactor when the first bioreactor is vitally supporting one or more first microorganisms and when the support structure is mechanically supporting the first bioreactor. Other embodiments of related systems and methods are also disclosed.
摘要翻译： 一些实施例包括具有被配置为机械地支撑第一生物反应器的支撑结构的系统。 支撑结构可以具有第一框架和第二框架，一起构造成在第一框架和第二框架之间插入中机械地支撑第一生物反应器。 第一框架可以通过第一框架和第一生物反应器之间的热能交换来保持第一生物反应器的第一设定点温度，当第一生物反应器维持一个或多个第一微生物时，并且当支撑结构机械地支撑第一生物反应器 生物反应器 还公开了相关系统和方法的其它实施例。
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公开(公告)号：US10184105B2
公开(公告)日：2019-01-22
申请号：US15143048
申请日：2016-04-29
发明人： Richard Mazur , Luke Cizek , Mason Oelschlager , Minh Duc Tram , Mason McCarty , Candyce Bair
摘要： Some embodiments include a method. The method includes: providing a support structure; and providing a bioreactor operable to vitally support one or more microorganisms. The bioreactor includes a bioreactor cavity configured to contain the one or more microorganisms and a fluidic support medium and one or more bioreactor walls at least partially enclosing the bioreactor cavity. The bioreactor wall(s) have at least one bioreactor wall material that is flexible. The support structure is operable to mechanically support the bioreactor. Other embodiments of related systems and methods are also disclosed.
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公开(公告)号：US10125346B2
公开(公告)日：2018-11-13
申请号：US15143012
申请日：2016-04-29
发明人： Luke Cizek , Mason Oelschlager , Justin Hayden , Mason McCarty
摘要： Some embodiments include a method. The method can include: conducting a first sterilization of an assembled bioreactor; after conducting the first sterilization of the assembled bioreactor, vitally supporting one or more first microorganisms with the assembled bioreactor; after vitally supporting the one or more first microorganisms with the assembled bioreactor, removing the one or more first microorganisms from the assembled bioreactor; after removing the one or more first microorganisms from the assembled bioreactor, gathering up the assembled bioreactor; after gathering up the assembled bioreactor, conducting a second sterilization of the assembled bioreactor; and after conducting the second sterilization of the assembled bioreactor, vitally supporting one or more second microorganisms with the assembled bioreactor. Other embodiments of related systems and methods are also disclosed.
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公开(公告)号：US10059918B2
公开(公告)日：2018-08-28
申请号：US15142964
申请日：2016-04-29
发明人： Luke Cizek , Mason Oelschlager , Justin Hayden , Miguel Olaizola , Mason McCarty , Richard Mazur
CPC分类号： C12N1/12 , C12M21/02 , C12M23/14 , C12M23/26 , C12M23/48 , C12M27/04 , C12M29/04 , C12M37/00 , C12M41/22 , C12M41/36 , C12M41/40
摘要： Some embodiments include a method. The method can include: inoculating a bioreactor with one or more first microorganisms and a first fluidic support medium, the bioreactor having one or more bioreactor walls at least partially enclosing a bioreactor cavity, being configured to be at least one of folded up or rolled up, and being sterile when the bioreactor is inoculated with the one or more first microorganisms, the one or more bioreactor walls having at least one bioreactor wall material, and the at least one bioreactor wall material being flexible and at least partially transparent; and vitally supporting the one or more first microorganisms with the bioreactor, a supply of light, and a supply of organic carbon. Other embodiments of related systems and methods are also disclosed.
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公开(公告)号：US20160289631A1
公开(公告)日：2016-10-06
申请号：US15143048
申请日：2016-04-29
发明人： Richard Mazur , Luke Cizek , Mason Oelschlager , Minh Duc Tram , Mason McCarty , Candyce Bair
CPC分类号： C12N1/12 , C12M21/02 , C12M23/14 , C12M23/26 , C12M23/48 , C12M37/00 , C12M41/22 , C12M41/36 , C12M41/40
摘要： Some embodiments include a method. The method includes: providing a support structure; and providing a bioreactor operable to vitally support one or more microorganisms. The bioreactor includes a bioreactor cavity configured to contain the one or more microorganisms and a fluidic support medium and one or more bioreactor walls at least partially enclosing the bioreactor cavity. The bioreactor wall(s) have at least one bioreactor wall material that is flexible. The support structure is operable to mechanically support the bioreactor. Other embodiments of related systems and methods are also disclosed.
摘要翻译： 一些实施例包括一种方法。 该方法包括：提供支撑结构; 以及提供可操作以至少支持一种或多种微生物的生物反应器。 生物反应器包括被配置为容纳一种或多种微生物和流体支持介质的生物反应器腔和至少部分地包围生物反应器腔的一个或多个生物反应器壁。 生物反应器壁具有至少一个柔性的生物反应器壁材料。 支撑结构可操作以机械地支撑生物反应器。 还公开了相关系统和方法的其它实施例。
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公开(公告)号：US20160289629A1
公开(公告)日：2016-10-06
申请号：US15142964
申请日：2016-04-29
发明人： Luke Cizek , Mason Oelschlager , Justin Hayden , Miguel Olaizola , Mason McCarty , Richard Mazur
IPC分类号： C12N1/12
CPC分类号： C12N1/12 , C12M21/02 , C12M23/14 , C12M23/26 , C12M23/48 , C12M27/04 , C12M29/04 , C12M37/00 , C12M41/22 , C12M41/36 , C12M41/40
摘要： Some embodiments include a method. The method can include: inoculating a bioreactor with one or more first microorganisms and a first fluidic support medium, the bioreactor having one or more bioreactor walls at least partially enclosing a bioreactor cavity, being configured to be at least one of folded up or rolled up, and being sterile when the bioreactor is inoculated with the one or more first microorganisms, the one or more bioreactor walls having at least one bioreactor wall material, and the at least one bioreactor wall material being flexible and at least partially transparent; and vitally supporting the one or more first microorganisms with the bioreactor, a supply of light, and a supply of organic carbon. Other embodiments of related systems and methods are also disclosed.
摘要翻译： 一些实施例包括一种方法。 该方法可以包括：用一种或多种第一微生物和第一流体支持介质接种生物反应器，所述生物反应器具有至少部分包围生物反应器空腔的一个或多个生物反应器壁，所述生物反应器壁被构造为折叠或卷起至少一个 并且当所述生物反应器被所述一种或多种第一微生物接种时是无菌的，所述一个或多个生物反应器壁具有至少一个生物反应器壁材料，并且所述至少一个生物反应器壁材料是柔性的并且至少部分透明; 并且通过生物反应器至少支持一种或多种第一微生物，提供光源和提供有机碳。 还公开了相关系统和方法的其它实施例。
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公开(公告)号：US10184099B2
公开(公告)日：2019-01-22
申请号：US15142811
申请日：2016-04-29
发明人： Richard Mazur , Luke Cizek , Mason Oelschlager , Mason McCarty , Minh Duc Tram , Justin Hayden , Candyce Bair
摘要： Some embodiments include a system having a support structure configured to mechanically support a first bioreactor. The support structure can have a first frame and a second frame together being configured to mechanically support the first bioreactor in interposition between the first frame and the second frame. The first frame can maintain a first set point temperature of the first bioreactor through an exchange of thermal energy between the first frame and the first bioreactor when the first bioreactor is vitally supporting one or more first microorganisms and when the support structure is mechanically supporting the first bioreactor. Other embodiments of related systems and methods are also disclosed.
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公开(公告)号：US10047337B2
公开(公告)日：2018-08-14
申请号：US15142913
申请日：2016-04-29
发明人： Luke Cizek , Miquel Olaizola , Mason McCarty , Mason Oelschlager
CPC分类号： C12N1/12 , C12M21/02 , C12M23/14 , C12M23/26 , C12M23/48 , C12M27/04 , C12M29/04 , C12M37/00 , C12M41/22 , C12M41/36 , C12M41/40
摘要： Some embodiments include a method of culturing one or more microalgae. The method can include: inoculating a bioreactor with the one or more microalgae and a fluidic support medium, the bioreactor having one or more bioreactor walls at least partially enclosing a bioreactor cavity, being configured to be at least one of folded up or rolled up, and being sterile when the bioreactor is inoculated with the one or more microalgae, the one or more bioreactor walls comprising at least one bioreactor wall material, and the at least one bioreactor wall material being flexible and at least partially transparent; and vitally supporting the one or more microalgae. Other embodiments of related systems and methods are also disclosed.
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公开(公告)号：US20160289630A1
公开(公告)日：2016-10-06
申请号：US15143012
申请日：2016-04-29
发明人： Luke Cizek , Mason Oelschlager , Justin Hayden , Mason McCarty
CPC分类号： C12N1/12 , A61L2/07 , A61L2/081 , C12M21/02 , C12M23/14 , C12M23/26 , C12M23/48 , C12M37/00 , C12M41/22 , C12M41/36
摘要： Some embodiments include a method. The method can include: conducting a first sterilization of an assembled bioreactor; after conducting the first sterilization of the assembled bioreactor, vitally supporting one or more first microorganisms with the assembled bioreactor; after vitally supporting the one or more first microorganisms with the assembled bioreactor, removing the one or more first microorganisms from the assembled bioreactor; after removing the one or more first microorganisms from the assembled bioreactor, gathering up the assembled bioreactor; after gathering up the assembled bioreactor, conducting a second sterilization of the assembled bioreactor; and after conducting the second sterilization of the assembled bioreactor, vitally supporting one or more second microorganisms with the assembled bioreactor. Other embodiments of related systems and methods are also disclosed.
摘要翻译： 一些实施例包括一种方法。 该方法可以包括：对组装的生物反应器进行第一次灭菌; 在组装的生物反应器进行第一次灭菌之后，用组装的生物反应器对一个或多个第一微生物进行极端支撑; 在用所组装的生物反应器对所述一种或多种第一微生物进行重要支持之后，从组装的生物反应器中除去所述一种或多种第一种微生物; 在从组装的生物反应器中除去一种或多种第一微生物之后，收集组装的生物反应器; 在收集组装的生物反应器之后，进行组装的生物反应器的第二次灭菌; 并且在组装的生物反应器进行第二次灭菌之后，用组装的生物反应器至少支撑一个或多个第二微生物。 还公开了相关系统和方法的其它实施例。
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