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公开(公告)号：US06815433B2
公开(公告)日：2004-11-09
申请号：US10002417
申请日：2001-10-25
申请人： Henri Hansson , Mats Lake , Kerstin Hansson
发明人： Henri Hansson , Mats Lake , Kerstin Hansson
IPC分类号： A61K31715
CPC分类号： A61K9/205 , A23L29/212 , A23L29/30 , A23P10/30 , A23P10/35 , A61K9/2054 , A61K31/718
摘要： Dysglucaemia is treated and/or prevented by the administration of granulated starch, enzymatically degraded and releasing reducing sugars at a rate, adjusted to the metabolism of the patient, suffering from dysglucaemia. For example nocturnal hypoglycaemia in diabetic patients is prevented by administering to said patients a granulate or tablets comprising granulated cornstarch, and preferably also heat treated cornstarch and a low calorie sweetener. The inventive granulation minimizes the available surface area and retards the enzymatic degradation of the cornstarch and ensures a controlled, e.g. a substantially linear release of reducing sugars, such as glucose, and a stable blood glucose level during several hours. The granulate or tablets are low in calories and contain no free sugar.
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公开(公告)号：US06815436B2
公开(公告)日：2004-11-09
申请号：US10202870
申请日：2002-07-26
申请人： Henri Hansson , Mats Lake , Kerstin Hansson
发明人： Henri Hansson , Mats Lake , Kerstin Hansson
IPC分类号： A61K3115
CPC分类号： A61K9/205 , A23L29/212 , A23L29/30 , A23P10/30 , A23P10/35 , A61K9/2054 , A61K31/718
摘要： Dysglucaemia is treated and/or prevented by the administration of granulated starch, enzymatically degraded and releasing reducing sugars at a rate, adjusted to the metabolism of the patient, suffering from dysglucaemia. For example nocturnal hypoglycaemia in diabetic patients is prevented by administering to said patients a granulate or tablets comprising granulated cornstarch, and preferably also heat treated cornstarch and a low calorie sweetener. The inventive granulation minimises the available surface area and retards the enzymatic degradation of the cornstarch and ensures a controlled, e.g. a substantially linear release of reducing sugars, such as glucose, and a stable blood glucose level during several hours. The granulate or tablets are low in calories and contain no free sugar.
摘要翻译： 通过施用造粒淀粉来治疗和/或预防糖尿病，通过调节至患有糖尿病的患者代谢的速率，酶促降解和释放还原糖。 例如，通过向所述患者施用包含颗粒状玉米淀粉，优选还加热处理的玉米淀粉和低热量甜味剂的颗粒或片剂来防止糖尿病患者的夜间低血糖。 本发明的造粒使可用的表面积最小化并延缓了玉米淀粉的酶降解，并确保了受控的例如。 在数小时内基本上线性释放还原糖，如葡萄糖，稳定的血糖水平。 颗粒或片剂的热量低，不含游离糖。
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公开(公告)号：US20050070502A1
公开(公告)日：2005-03-31
申请号：US10953453
申请日：2004-09-30
申请人： Henri Hansson , Mats Lake , Kerstin Hansson
发明人： Henri Hansson , Mats Lake , Kerstin Hansson
IPC分类号： A61K9/16 , A23L1/00 , A23L1/0522 , A23L1/09 , A23P1/04 , A61K9/20 , A61K31/718 , A61K47/12 , A61K47/36 , A61K47/38 , A61K47/44 , A61K47/46 , A61P3/10
CPC分类号： A61K9/205 , A23L29/212 , A23L29/30 , A23P10/30 , A23P10/35 , A61K9/2054 , A61K31/718
摘要： Dysglucaemia is treated and/or prevented by the administration of granulated starch, enzymatically degraded and releasing reducing sugars at a rate, adjusted to the metabolism of the patient, suffering from dysglucaemia. For example nocturnal hypoglycaemia in diabetic patients is prevented by administering to said patients a granulate or tablets comprising granulated cornstarch, and preferably also heat treated cornstarch and a low calorie sweetener. The inventive granulation minimises the available surface area and retards the enzymatic degradation of the cornstarch and ensures a controlled, e.g. a substantially linear release of reducing sugars, such as glucose, and a stable blood glucose level during several hours. The granulate or tablets are low in calories and contain no free sugar.
摘要翻译： 通过施用造粒淀粉来治疗和/或预防糖尿病，通过调节至患有糖尿病的患者代谢的速率，酶促降解和释放还原糖。 例如，通过向所述患者施用包含颗粒状玉米淀粉，优选还加热处理的玉米淀粉和低热量甜味剂的颗粒或片剂来防止糖尿病患者的夜间低血糖。 本发明的造粒使可用的表面积最小化并延缓了玉米淀粉的酶降解，并确保了受控的例如。 在数小时内基本上线性释放还原糖，如葡萄糖，稳定的血糖水平。 颗粒或片剂的热量低，不含游离糖。
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公开(公告)号：US20100061940A1
公开(公告)日：2010-03-11
申请号：US12225260
申请日：2007-03-16
申请人： Anders Axelsson , Henri Hansson , Arne Kristensen
发明人： Anders Axelsson , Henri Hansson , Arne Kristensen
IPC分类号： A61K9/68
CPC分类号： A61K9/0058 , A23G4/06 , A23G4/10 , A61K31/465
摘要： Use of a nicotine-cellulose combination and a gum base for the preparation of a chewing gum composition for achieving a fast onset of nicotine effect after initiation of chewing the chewing gum composition by a subject. The chewing gum composition is preferably prepared by direct compression and it does not disintegrate during chewing. The invention also relates to chewing gum compositions comprising nicotine, which compositions provide a rapid release of nicotine.
摘要翻译： 使用尼古丁 - 纤维素组合和胶基制备口香糖组合物，以在受试者开始咀嚼口香糖组合物之后实现尼古丁效应的快速发作。 口香糖组合物优选通过直接压片制备，并且其在咀嚼期间不分解。 本发明还涉及包含尼古丁的口香糖组合物，该组合物提供尼古丁的快速释放。
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公开(公告)号：US20120128736A1
公开(公告)日：2012-05-24
申请号：US13319760
申请日：2010-05-12
申请人： Henri Hansson , Anna Karin Morén
发明人： Henri Hansson , Anna Karin Morén
CPC分类号： A61K9/0014 , A61K47/10
摘要： Novel pharmaceutical compositions of mometasone or a pharmaceutically acceptable derivate thereof in the form of an oil-in-water emulsion, notably a cream. The composition has excellent stability and therapeutic effect. The compositions contain mometasone in micronised form, butylene glycol and water and the weight ratio between the butylene glycol and water contained in the oil-in-water emulsion is from 1:1 to about 1:3.
摘要翻译： 米索糖或其药学上可接受的衍生物的新型药物组合物以水包油乳液，特别是乳剂的形式。 该组合物具有优异的稳定性和治疗效果。 组合物含有微粉化形式的莫米松，丁二醇和水，并且水包油乳液中所含的丁二醇与水的重量比为1:1至约1:3。
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公开(公告)号：US07900637B2
公开(公告)日：2011-03-08
申请号：US10481979
申请日：2002-06-24
CPC分类号： A61M15/00
摘要： The present invention relates to an aerosol spray device (10, 20, 30, 40) for administration of a substance, specifically a substance having a disagreeable taste, such as nicotine, to the oral cavity of a subject; to an actuator (16, 26, 36, 46) included in said spray device and to methods for delivering the substance.
摘要翻译： 本发明涉及一种用于向受试者的口腔施用物质，特别是具有不愉快味道的物质，例如尼古丁的气溶胶喷雾装置（10,20,30,40） 包括在所述喷射装置中的致动器（16,26,36,46）以及用于输送物质的方法。
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公开(公告)号：US20050084526A1
公开(公告)日：2005-04-21
申请号：US10501899
申请日：2003-01-21
申请人： Jari Alander , Staffan Norberg , Henri Hansson , Marianne Svard , Lars Hovgaard
发明人： Jari Alander , Staffan Norberg , Henri Hansson , Marianne Svard , Lars Hovgaard
CPC分类号： A61K9/1617 , A61K9/1075 , A61K9/1274 , A61K9/1694 , A61K9/2013 , A61K9/2018 , A61K9/2027
摘要： The invention refers to a process for the preparation of a self-dispersing or self-emulsifying tablet comprising the steps mixing a granulation medium containing an active lipophilic substance with one or more fillers and auxiliary components, granulation of said mixture into granules, drying of said granules, sieving of the granules into a homogeneous size, mixing of the granules with tabletting aids, and compressing said mixture into tablets, which is characterised in that the granulation medium comprises an oil, a surfactant and a polar liquid. The invention also refers to a process for the preparation of tablets from a granulation medium comprising oil and surfactant, as well as to tablets prepared by said processes.
摘要翻译： 本发明涉及一种制备自分散或自乳化片剂的方法，包括将含有活性亲脂性物质的造粒介质与一种或多种填料和辅助成分混合的步骤，将所述混合物造粒成颗粒，将所述 颗粒，将颗粒筛分成均匀的尺寸，将颗粒与压片助剂混合，并将所述混合物压制成片剂，其特征在于造粒介质包含油，表面活性剂和极性液体。 本发明还涉及从包含油和表面活性剂的造粒介质以及由所述方法制备的片剂制备片剂的方法。
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公开(公告)号：US08728497B2
公开(公告)日：2014-05-20
申请号：US13319758
申请日：2010-05-12
申请人： Henri Hansson , Anna Karin Morén
发明人： Henri Hansson , Anna Karin Morén
IPC分类号： A61K9/107
CPC分类号： A61K31/58 , A61K9/0014 , A61K9/107 , A61K47/10
摘要： Novel pharmaceutical compositions of mometasone or a pharmaceutically acceptable derivate thereof in the form of an oil-in-water emulsion, notably a cream. The composition has excellent stability and therapeutic effect. The compositions contain mometasone in micronised form, propylene glycol and water and the weight ratio between the propylene glycol and water contained in the oil-in-water emulsion is from 1:1 to about 1:3.
摘要翻译： 米索糖或其药学上可接受的衍生物的新型药物组合物以水包油乳液，特别是乳剂的形式。 该组合物具有优异的稳定性和治疗效果。 组合物含有微粉化形式的莫米松，丙二醇和水，并且水包油乳液中所含的丙二醇与水的重量比为1:1至约1:3。
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公开(公告)号：US06203519B1
公开(公告)日：2001-03-20
申请号：US09029597
申请日：1998-03-26
IPC分类号： A61M3700
CPC分类号： A61M13/00 , A61M2250/00
摘要： An insufflator assembly, comprising: an insufflator comprising a delivery component (1) for delivering powder into an airway of an animal, a metering component (3) for providing a dose of powder (P) to the delivery component (1) and an inlet for receiving a stream of gas; and means for providing a stream of gas to the inlet of the insufflator so as to carry the dose of powder (P) into the airway of the animal, the means comprising a chamber (45) of a predetermined volume for containing gas at a predetermined pressure above atmospheric, a pressurized gas source (9) for providing gas of a predetermined pressure to the chamber (45), a first valve (47) for selectively connecting the chamber (45) to the pressurized gas source (9) and a second valve (49) for selectively connecting the chamber (45) to the inlet of the insufflator.
摘要翻译： 一种吹入器组件，包括：吹入器，其包括用于将粉末输送到动物气道中的输送组件（1），用于向所述输送组件（1）提供一定剂量的粉末（P）的计量组件（3） 用于接收气流; 以及用于向所述吹入器的入口提供气流以将粉末（P）的剂量携带到动物的气道中的装置，所述装置包括预定体积的室（45），用于容纳预定的气体 压力高于大气压，用于向腔室（45）提供预定压力的气体的加压气体源（9），用于选择性地将腔室（45）连接到加压气体源（9）的第一阀门（47） 阀（49），用于选择性地将腔室（45）连接到吹入器的入口。
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公开(公告)号：US5918594A
公开(公告)日：1999-07-06
申请号：US817800
申请日：1997-04-10
申请人： Lars Asking , Kjell Backstrom , Henri Hansson , Magnus Jahnsson
发明人： Lars Asking , Kjell Backstrom , Henri Hansson , Magnus Jahnsson
CPC分类号： A61M15/00 , A61M11/002 , A61M2202/064
摘要： An inhalation device comprising means for breaking down aggregates of finely divided powdered medicament to provide medicament having a large number of particles within the respiratory range (less than 10 .mu.m). The deaggregation means comprise at least two pairs of opposing surfaces in a gas/air flow path. The first pair define an inlet to a constricted region in the air flow path, and the second pair are located at or near the outlet of the constriction. The two pairs of surfaces are oriented at different angles with respect to the axis of the air flow path. In use, medicament particles carried by the gas/air flow impact the first pair of surfaces, then enter the constricted region where the speed of the gas/air flow is increased, and then impact the second pair of surfaces. The impacts break down agglomerations of the finely divided medicament, thereby delivering to the user a greater number of particles in the respiratory range.
摘要翻译： PCT No.PCT / SE96 / 00969 Sec。 371日期1997年04月10日 102（e）1997年4月10日PCT PCT 1996年7月23日PCT公布。 出版物WO97 / 05917 日期1997年2月20日一种吸入装置，其包括用于分解细碎粉末状药物的聚集体的装置，以提供在呼吸范围内（小于10微米）具有大量颗粒的药物。 解聚集装置包括气/气流动路径中的至少两对相对的表面。 第一对限定了空气流动路径中的收缩区域的入口，并且第二对位于收缩部的出口处或附近。 两对表面相对于空气流路的轴线以不同的角度定向。 在使用中，由气/气流携带的药物颗粒冲击第一对表面，然后进入气/气流速度增加的收缩区域，然后冲击第二对表面。 这种影响破坏了细碎药物的聚集体，从而在呼吸范围内向使用者输送更多数量的颗粒。
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