公开(公告)号：US08034379B2

公开(公告)日：2011-10-11

申请号：US10381714

申请日：2001-09-28

申请人： Henricus R. M. Gorissen ,  Henderik W. Frijlink

发明人： Henricus R. M. Gorissen ,  Henderik W. Frijlink

IPC分类号： A61K9/20 ,  A61K9/28 ,  A61K9/14

CPC分类号： A61K9/0065 ,  A61K9/2054

摘要： The present invention is related to an optionally coated pharmaceutical hydrophilic gel forming matrix formulation comprising one or more active substances and having a prolonged release of said one or more active substances upon exposure to gastrointestinal fluids, characterized in that said release is substantially ion-strength independent. The invention is further related to a method of preparing this formulation which can be used in the administration of active substances for the treatment of a large number of disorders.

摘要翻译： 本发明涉及包含一种或多种活性物质并且在暴露于胃肠液体时延长释放所述一种或多种活性物质的任选包被的药物亲水凝胶形成基质制剂，其特征在于所述释放基本上是离子强度独立的 。 本发明还涉及制备该制剂的方法，该方法可用于施用活性物质以治疗大量的病症。

公开(公告)号：US06872723B2

公开(公告)日：2005-03-29

申请号：US10346597

申请日：2003-01-17

申请人： Henderik W. Frijlink

发明人： Henderik W. Frijlink

IPC分类号： A61K31/495 ,  A61K47/10 ,  A61K47/18 ,  A61K31/497

CPC分类号： A61K31/4709 ,  A61K31/495 ,  A61K47/10 ,  A61K47/183

摘要： An antibacterial formulation suitable for injection into animals containing approximately 2-10% w/v difloxacin HCl, L-arginine base, propylene glycol, ethanol and/or benzyl alcohol, and water. The formulation is a solution having a pH of form 9 to 10. The formulation produces little or no tissue damage or irritation at the injection site.

摘要翻译： 适用于注射到含有约2-10％w / v的氟沙星HCl，L-精氨酸碱，丙二醇，乙醇和/或苄醇和水中的抗菌制剂。 制剂是pH为9-10的溶液。该制剂在注射部位几乎不产生组织损伤或刺激。

公开(公告)号：US06183780B2

公开(公告)日：2001-02-06

申请号：US08934196

申请日：1997-09-19

申请人： Paulus M. Van Balken ,  Jules A. C. Elbers ,  Henderik W. Frijlink ,  Wienman E. Philips

发明人： Paulus M. Van Balken ,  Jules A. C. Elbers ,  Henderik W. Frijlink ,  Wienman E. Philips

IPC分类号： A61K936

CPC分类号： A61K39/145 ,  A61K9/282 ,  A61K9/2866 ,  A61K9/4808 ,  A61K39/00 ,  A61K39/12

摘要： The invention relates to an Oral Delayed Immediate Release formulation comprising a compressed core containing one or more active substances surrounded with a coating, wherein release of active substance from the core is caused by rupture of the coating after a definite lag-time, said core comprising one or more immediate release carriers and having no substantial swelling properties upon exposure to gastrointestinal fluids. The invention further relates to formulations containing an Immediate Release formulation combined with one or more Oral Delayed Immediate Release formulations with different lag-times and to a method of preparing an Oral Delayed Immediate Release formulation. The Oral Delayed Immediate Release formulation may be used for the application of active substances whenever a certain lag-time before release is advantageous, such as in be the case of anti-asthmatics, anti-emetics, cardiotonics, vasodilators, anti-vertigo and anti-meniere compounds, anti-hypertensives, sedatives, anti-depressants, anti-anxiety compounds, cortico-steroids, general anti-inflammatory compounds, anti-inflammatory compounds for gastrointestinal use, anti-ulceratives, analgetics, anti-aritmics, anti-rheumatics, anti-arthritic compounds and anti-angina compounds. The Oral Delayed Immediate Release formulation may also be used for the application of biological active compounds such as proteins, peptides, enzymes, vaccines and oligonucleotides.

摘要翻译： 本发明涉及一种口服延迟立即释放制剂，其包含含有一层或多层被涂层包围的活性物质的压缩芯，其中活性物质从核心中的释放是由确定的滞后时间之后的涂层破裂引起的，所述芯包含 一种或多种立即释放载体，并且在暴露于胃肠液体时不具有显着的溶胀特性。 本发明还涉及含有立即释放制剂与一种或多种具有不同滞后时间的口服延迟立即释放制剂组合的制剂以及制备口服延迟立即释放制剂的方法。口服延迟立即释放制剂可用于 抗发炎，强心剂，血管扩张剂，抗眩晕和抗月桂基化合物，抗高血压药，镇静剂，抗高血压药，抗高血压药，抗高血压药，抗高血压药，抗高血压药 抗焦虑剂，皮质类固醇，一般抗炎化合物，消化道用抗炎化合物，抗溃疡剂，止痛剂，抗神经病，抗风湿药，抗关节炎化合物和抗心绞痛药物。 口服延迟即时释放制剂也可用于生物活性化合物如蛋白质，肽，酶，疫苗的应用 s和寡核苷酸。

公开(公告)号：US07273870B2

公开(公告)日：2007-09-25

申请号：US11071824

申请日：2005-03-03

申请人： Henderik W. Frijlink

发明人： Henderik W. Frijlink

IPC分类号： A61K31/497

CPC分类号： A61K31/4709 ,  A61K31/495 ,  A61K47/10 ,  A61K47/183

摘要： An antibacterial formulation suitable for injection into animals containing approximately 2-10% w/v difloxacin HCl, L-arginine base, propylene glycol, ethanol and/or benzyl alcohol, and water. The formulation is a solution having a pH of form 9 to 10. The formulation produces little or no tissue damage or irritation at the injection site.

摘要翻译： 适用于注射到含有约2-10％w / v的氟沙星HCl，L-精氨酸碱，丙二醇，乙醇和/或苄醇和水中的抗菌制剂。 制剂是pH为9-10的溶液。该制剂在注射部位几乎不产生组织损伤或刺激。