公开(公告)号：US07892254B2

公开(公告)日：2011-02-22

申请号：US10813783

申请日：2004-03-30

申请人： Henrik S. Klint ,  Arne Molgaard-Nielsen ,  Erik E. Rasmussen

发明人： Henrik S. Klint ,  Arne Molgaard-Nielsen ,  Erik E. Rasmussen

IPC分类号： A61B17/08 ,  A61M29/00 ,  A61F2/02

CPC分类号： A61B17/12022 ,  A61B17/12109 ,  A61B17/12113 ,  A61B17/12145 ,  A61B17/12172 ,  A61B2017/12095

摘要： An embolization device for positioning in a blood vessel comprises an elongated wire body (1) which in its unloaded condition has a predetermined shape and has an elongated shape with a substantially straight center line during its insertion through a catheter (18) to a placement site in the blood vessel and after its release from the catheter assumes a complexly curved shape which depends on the predetermined shape and on the blood vessel impact on the wire body. In its predetermined shape the wire body has at least one section (4) located between its front and back ends in which the center line has substantially no curvature or such a small curvature that along a length of at least 20 mm it follows a helix-free path. The front end section (2, 2″, 2′″) of the wire body is adapted to be frictionally locked to the vessel wall when discharged from the catheter, before said helix-free section (4) has been discharged from the catheter. When the helix-free section (4) is discharged it will bend sideways and seek towards the middle of the vessel lumen and continue towards the opposite vessel wall where it is frictionally locked. At continued pushing out many such vessel-crossing wire portions (20) occur, which provides efficient occlusion of the vessel. One advantage of the embolization device is that it may be used to occlude blood vessel areas. Accordingly, a method is described for occluding a blood vessel area using the wire body (1).

摘要翻译： 用于定位在血管中的栓塞装置包括细长线体（1），其在其卸载状态下具有预定形状并且具有细长形状，在其通过导管（18）插入到放置位置时具有基本上直的中心线 在血管中并且在其从导管释放之后呈现出取决于预定形状和血管对线体的冲击的复杂曲线形状。 在其预定形状中，线体具有位于其前端和后端之间的至少一个部分（4），其中中心线基本上没有曲率或沿着至少20mm的长度的曲率， 自由之路 线体的前端部分（2,2'，2“）适于在从导管排出之前，在从导管排出所述无螺旋部分（4）之前摩擦地锁定到血管壁。 当无螺旋部分（4）被排出时，它将侧向弯曲并且朝着血管腔的中间寻求并且继续朝向相对的血管壁，在那里被摩擦锁定。 继续推出许多这样的容器交叉电线部分（20），这提供了容器的有效闭塞。 栓塞装置的一个优点是可用于阻塞血管区域。 因此，描述了使用线体（1）闭塞血管区域的方法。

公开(公告)号：US06776788B1

公开(公告)日：2004-08-17

申请号：US08923061

申请日：1997-09-03

申请人： Henrik S. Klint ,  Arne Molgaard-Nielsen ,  Erik E. Rasmussen

发明人： Henrik S. Klint ,  Arne Molgaard-Nielsen ,  Erik E. Rasmussen

IPC分类号： A61M2900

CPC分类号： A61B17/12022 ,  A61B17/12109 ,  A61B17/12113 ,  A61B17/12145 ,  A61B17/12172 ,  A61B2017/12095

摘要： An embolization device for positioning in a blood vessel comprises an elongated wire body (1) which in its unloaded condition has a predetermined shape and has an elongated shape with a substantially straight center line during its insertion through a catheter (18) to a placement site in the blood vessel and after its release from the catheter assumes a complexly curved shape which depends on the predetermined shape and on the blood vessel impact on the wire body. In its predetermined shape the wire body has at least one section (4) located, between its front and back ends in which the center line has substantially no curvature or such a small curvature that along a length of at least 20 mm it follows a helix-free path. The front end section (2, 2″, 2′″) of the wire body is adapted to be frictionally locked to the vessel wall when discharged from the catheter, before said helix-free section (4) has been discharged from the catheter. When the helix-free section (4) is discharged it will bend sideways and seek towards the middle of the vessel lumen and continue towards the opposite vessel wall where it is frictionally locked. At continued pushing out many such vessel-crossing wire portions (20) occur, which provides efficient occlusion of the vessel.

摘要翻译： 用于定位在血管中的栓塞装置包括细长线体（1），其在其卸载状态下具有预定形状并且具有细长形状，在其通过导管（18）插入到放置位置时具有基本上直的中心线 在血管中并且在其从导管释放之后呈现出取决于预定形状和血管对线体的冲击的复杂曲线形状。 在其预定形状中，线体具有位于其前端和后端之间的至少一个部分（4），其中心线基本上没有曲率或者沿着至少20mm的长度的小曲率，其沿着螺旋 - 自由路径。 线体的前端部分（2,2“，2”）适于在从导管排出之前摩擦地锁定到容器壁上，在所述无螺旋部分（4）从 导管。 当无螺旋部分（4）被排出时，它将侧向弯曲并且朝着血管腔的中间寻求并且继续朝向相对的血管壁，在那里被摩擦锁定。 继续推出许多这样的容器交叉电线部分（20），这提供了容器的有效闭塞。

公开(公告)号：US08246651B2

公开(公告)日：2012-08-21

申请号：US12717637

申请日：2010-03-04

申请人： Per Hendriksen ,  Allan G. Hemmingsen ,  Arne Molgaard-Nielsen ,  Thomas A. Osborne ,  Rolf Gunther

发明人： Per Hendriksen ,  Allan G. Hemmingsen ,  Arne Molgaard-Nielsen ,  Thomas A. Osborne ,  Rolf Gunther

IPC分类号： A61M29/00

CPC分类号： A61F2/01 ,  A61F2002/011 ,  A61F2002/016 ,  A61F2002/8483 ,  A61F2230/005 ,  A61F2230/0067 ,  A61F2230/008

摘要： The present invention provides a method of capturing thrombi in a blood vessel, which includes delivering a removable filter in a collapsed state within the blood vessel and deploying the filter to an expanded state within the blood vessel. The filter includes a plurality of primary struts and a plurality of secondary struts emanating from a hub and extending arcuately along a longitudinal axis and linearly radially. Each primary strut has an arcuate segment including first and second curved portions. Each secondary strut includes first and second arcs. The primary struts terminate with an anchoring hook. Each primary strut crosses another primary strut along the longitudinal axis in the collapsed state such that the arcuate segments occupy a first diameter and the anchoring hooks occupy a second diameter, the first diameter being greater than the second diameter for filter retrieval or delivery. In the expanded state, the secondary struts centralize the filter in the blood vessel and the anchoring hooks engage with the blood vessel.

摘要翻译： 本发明提供了一种在血管中捕获血栓的方法，其包括在血管内以折叠状态递送可移除的过滤器，并将该过滤器展开至血管内的扩张状态。 过滤器包括多个主支柱和从轮毂发出并沿着纵向轴线弧形延伸并且线性地径向延伸的多个辅助支柱。 每个主支柱具有包括第一和第二弯曲部分的弓形段。 每个辅助支柱包括第一和第二弧。 主支柱终止于锚钩。 每个主支柱在收缩状态下沿着纵向轴线跨越另一个主支柱，使得弓形段占据第一直径，并且锚定钩占据第二直径，第一直径大于用于过滤器取出或输送的第二直径。 在扩张状态下，副支柱将过滤器集中在血管中，并且锚钩与血管接合。

公开(公告)号：US08167901B2

公开(公告)日：2012-05-01

申请号：US11235801

申请日：2005-09-27

申请人： Per Hendriksen ,  Allan G. Hemmingsen ,  Arne Molgaard-Nielsen ,  Thomas A. Osborne

发明人： Per Hendriksen ,  Allan G. Hemmingsen ,  Arne Molgaard-Nielsen ,  Thomas A. Osborne

IPC分类号： A61M29/00

CPC分类号： A61F2/01 ,  A61F2002/016 ,  A61F2230/005 ,  A61F2230/008

摘要： A removable vena cava filter configured for simplified delivery to and retrieval from the vena cava of a patient is disclosed. The filter includes struts configured to be arranged in consistent orientation together between expanded (opened) and collapsed (closed) configurations, thereby minimizing entanglement of the struts. Each of the struts has a circumferential bend relative to the longitudinal axis of the filter. The circumferential bends allow for consistent orientation of the struts when moved between the expanded and collapsed configurations and when placed in the closed configuration of the filter.

摘要翻译： 公开了一种可移动的腔静脉过滤器，其被配置为简化输送到患者的腔静脉和从腔静脉取出。 过滤器包括构造成在膨胀（打开）和折叠（闭合）构造之间一致定向布置的支柱，从而最小化支柱的缠结。 每个支柱相对于过滤器的纵向轴线具有圆周弯曲。 当在膨胀和收缩构型之间移动时以及当放置在过滤器的关闭构造中时，圆周弯曲允许支柱一致地定向。

公开(公告)号：US08043322B2

公开(公告)日：2011-10-25

申请号：US11108264

申请日：2005-04-18

申请人： Per Hendriksen ,  Allan Hemmingsen ,  Arne Molgaard-Nielsen ,  Thomas A. Osborne

发明人： Per Hendriksen ,  Allan Hemmingsen ,  Arne Molgaard-Nielsen ,  Thomas A. Osborne

IPC分类号： A61M29/00

CPC分类号： A61F2/01 ,  A61F2002/011 ,  A61F2002/016 ,  A61F2002/8483 ,  A61F2230/005 ,  A61F2230/008

摘要： The present invention involves a removable filter for capturing thrombi in a blood vessel. The filter comprises a plurality of primary struts and a plurality of secondary struts. The plurality of primary struts has first ends attached together along a longitudinal axis. Each primary strut has an arcuate segment extending from the first end to an anchoring hook. The primary struts are configured to move between an expanded state for engaging the anchoring hooks with the blood vessel and a collapsed state for filter retrieval or delivery. Each primary strut is configured to cross another primary strut along the longitudinal axis in the collapsed state such that each anchoring hook faces the longitudinal axis away from the blood vessel for filter retrieval or delivery. The plurality of secondary struts has connected ends attached together along the longitudinal axis. The secondary struts extend therefrom to free ends to centralize the filter in the expanded in the blood vessel.

摘要翻译： 本发明涉及用于在血管中捕获血栓的可移除过滤器。 过滤器包括多个主支柱和多个辅助支柱。 多个主支柱具有沿着纵向轴线连接在一起的第一端。 每个主支柱具有从第一端延伸到锚钩的弓形段。 主支柱构造成在用于使锚钩与血管接合的扩张状态和用于过滤器取出或输送的折叠状态之间移动。 每个主支柱构造成在收缩状态下沿着纵向轴线穿过另一个主支柱，使得每个锚定钩面向远离血管的纵向轴线用于过滤器取出或输送。 多个辅助支柱具有沿着纵向轴线连接在一起的连接端。 次级支柱从其延伸到自由端以将过滤器集中在血管中扩张的过滤器中。

公开(公告)号：US20070203520A1

公开(公告)日：2007-08-30

申请号：US11654278

申请日：2007-01-16

申请人： Dennis Griffin ,  Arne Molgaard-Nielsen ,  Anthony Ragheb ,  Raymond Leonard ,  Neal Fearnot ,  William Voorhees ,  Thomas Kozma ,  Brian Bates ,  Thomas Osborne

发明人： Dennis Griffin ,  Arne Molgaard-Nielsen ,  Anthony Ragheb ,  Raymond Leonard ,  Neal Fearnot ,  William Voorhees ,  Thomas Kozma ,  Brian Bates ,  Thomas Osborne

IPC分类号： A61M29/00

CPC分类号： A61F2/01 ,  A61F2002/016 ,  A61F2230/005 ,  A61F2230/0086 ,  A61F2250/0067

摘要： Endovascular filter (10) including a plurality of struts (14) with distal ends (18) adapted to anchor the filter to the vessel wall after deployment, such as by having barbs (20), the filter being adapted to be retrieved if desired. Strut distal ends (18) are coated with an antiproliferative agent (40) that inhibits the ingrowth of tissue around the filter, thereby permitting the filter to be retrieved and removed atraumatically after a prolonged period of time, thus extending the useful life of the retrievable filter. Optionally, the proximal end (22) of the filter may also be so coated, or the entire filter.

摘要翻译： 包括具有远端（18）的多个支柱（14）的血管内过滤器（10），其适于在部署之后将过滤器锚定到血管壁，例如通过具有倒钩（20），如果需要，该过滤器适于被检索。 支架远端（18）涂覆有抗增殖剂（40），其抑制过滤器周围的组织的向内生长，从而允许过滤器在延长的时间段后无损伤地取出和去除，从而延长可回收的使用寿命 过滤。 可选地，过滤器的近端（22）也可以如此涂覆，或整个过滤器。

公开(公告)号：US20050267514A1

公开(公告)日：2005-12-01

申请号：US11108255

申请日：2005-04-18

申请人： Thomas Osborne ,  Arne Molgaard-Nielsen ,  Per Hendriksen ,  Rolf Gunther

发明人： Thomas Osborne ,  Arne Molgaard-Nielsen ,  Per Hendriksen ,  Rolf Gunther

IPC分类号： A61F2/01 ,  A61M29/00

CPC分类号： A61F2/01 ,  A61F2002/011 ,  A61F2002/016 ,  A61F2230/005 ,  A61F2230/008

摘要： The present invention provides a removable vena cava filter for capturing thrombi in a blood vessel. The filter comprises a plurality of primary struts having first ends attached together along a longitudinal axis. Each primary strut includes an arcuate segment having a first tensile strength. The arcuate segment extends from the first end to an anchoring hook. The anchoring hook is integral with the arcuate segment and having the first thickness and first tensile strength. The filter further comprises a plurality of secondary struts freely spaced between the primary struts and having connected ends attached together along the longitudinal axis. Each secondary strut freely extends from the connected end to a free end avoiding contact with other secondary struts and primary struts. Each secondary strut has a second tensile strength.

摘要翻译： 本发明提供一种用于在血管中捕获血栓的可移除的腔静脉过滤器。 过滤器包括多个主支柱，其具有沿着纵向轴线连接在一起的第一端。 每个主支柱包括具有第一拉伸强度的弓形段。 弧形段从第一端延伸到锚钩。 锚定钩与弓形段成一体，具有第一厚度和第一拉伸强度。 过滤器还包括多个辅助支柱，其在主支柱之间自由间隔开并且具有沿着纵向轴线连接在一起的连接端。 每个辅助支柱从连接端自由延伸到自由端，避免与其他辅助支柱和主支柱接触。 每个辅助支柱具有第二拉伸强度。

公开(公告)号：US09308066B2

公开(公告)日：2016-04-12

申请号：US13521458

申请日：2011-01-12

申请人： Arne Molgaard-Nielsen ,  Jacob Lund Clausen ,  Per Hendriksen

发明人： Arne Molgaard-Nielsen ,  Jacob Lund Clausen ,  Per Hendriksen

IPC分类号： A61M29/00 ,  A61F2/00 ,  A61F2/01 ,  A61F2/30

CPC分类号： A61F2/01 ,  A61F2/00 ,  A61F2002/016 ,  A61F2002/30322 ,  A61F2220/0016 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2230/005 ,  A61F2230/008 ,  A61F2250/0026 ,  A61F2250/0098

摘要： A removable vena cava filter (10) configured for reduced trauma and enhanced visualization of anchoring hook placement relative to the vessel wall is disclosed. The filter includes a plurality of struts (12a-d), each having an anchoring hook (26) and a stop member (24) proximate the anchoring hook. The stop members are configured to engage the vessel wall to prevent excessive penetration of the anchoring hooks into the vessel wall and to aid in the identification of anchoring hook placement relative to the vessel wall.

摘要翻译： 公开了可拆卸的腔静脉过滤器（10），其被配置为相对于血管壁减少创伤并增强锚固钩位置的可视化。 过滤器包括多个支柱（12a-d），每个支柱具有一个固定钩（26）和靠近锚定钩的止动构件（24）。 止动构件被构造成接合血管壁以防止锚钩过度地穿入血管壁并且有助于相对于血管壁识别锚定钩位置。

公开(公告)号：US08105349B2

公开(公告)日：2012-01-31

申请号：US11108254

申请日：2005-04-18

申请人： Per Hendriksen ,  Allan G. Hemmingsen ,  Arne Molgaard-Nielsen ,  Thomas A. Osborne ,  Rolf Gunther

发明人： Per Hendriksen ,  Allan G. Hemmingsen ,  Arne Molgaard-Nielsen ,  Thomas A. Osborne ,  Rolf Gunther

IPC分类号： A61M29/00

CPC分类号： A61F2/01 ,  A61F2002/011 ,  A61F2002/016 ,  A61F2230/005 ,  A61F2230/008

摘要： A removable filter having a collapsed state and an expanded state for capturing thrombi in a blood vessel is disclosed. The filter comprises a plurality of primary struts and a plurality of secondary struts. Each primary strut in the expanded state extends from a primary strut first end to an anchoring hook. Each primary strut extends arcuately along a longitudinal axis and linearly radially. The plurality of primary strut first ends are attached together along the longitudinal axis. Each secondary strut in the expanded state extends from a secondary strut first end to a free end. Each secondary strut extends arcuately along the longitudinal axis and linearly radially. The plurality of secondary struts are attached together along the longitudinal axis. The plurality of secondary struts centralize the filter in the expanded state in the blood vessel.

摘要翻译： 公开了一种具有收缩状态和用于在血管中捕获血栓的膨胀状态的可移除过滤器。 过滤器包括多个主支柱和多个辅助支柱。 处于膨胀状态的每个主支柱从主支柱第一端延伸到锚钩。 每个主支柱沿着纵向轴线弧线延伸并且线性地径向延伸。 多个主支柱第一端沿着纵向轴线连接在一起。 处于膨胀状态的每个辅助支柱从辅助支柱第一端延伸到自由端。 每个辅助支柱沿着纵向轴线弧线延伸并且线性地径向延伸。 多个辅助支柱沿着纵向轴线连接在一起。 多个次级支柱将血管中处于膨胀状态的过滤器集中。

公开(公告)号：US20100160956A1

公开(公告)日：2010-06-24

申请号：US12717637

申请日：2010-03-04

申请人： Per Hendriksen ,  Allan G. Hemmingsen ,  Arne Molgaard-Nielsen ,  Thomas A. Osborne ,  Rolf Gunther

发明人： Per Hendriksen ,  Allan G. Hemmingsen ,  Arne Molgaard-Nielsen ,  Thomas A. Osborne ,  Rolf Gunther

IPC分类号： A61F2/01

CPC分类号： A61F2/01 ,  A61F2002/011 ,  A61F2002/016 ,  A61F2002/8483 ,  A61F2230/005 ,  A61F2230/0067 ,  A61F2230/008

摘要： The present invention provides a method of capturing thrombi in a blood vessel, which includes delivering a removable filter in a collapsed state within the blood vessel and deploying the filter to an expanded state within the blood vessel. The filter includes a plurality of primary struts and a plurality of secondary struts emanating from a hub and extending arcuately along a longitudinal axis and linearly radially. Each primary strut has an arcuate segment including first and second curved portions. Each secondary strut includes first and second arcs. The primary struts terminate with an anchoring hook. Each primary strut crosses another primary strut along the longitudinal axis in the collapsed state such that the arcuate segments occupy a first diameter and the anchoring hooks occupy a second diameter, the first diameter being greater than the second diameter for filter retrieval or delivery. In the expanded state, the secondary struts centralize the filter in the blood vessel and the anchoring hooks engage with the blood vessel.

摘要翻译： 本发明提供了一种在血管中捕获血栓的方法，其包括在血管内以折叠状态递送可移除的过滤器，并将该过滤器展开至血管内的扩张状态。 过滤器包括多个主支柱和从轮毂发出并沿着纵向轴线弧形延伸并且线性地径向延伸的多个辅助支柱。 每个主支柱具有包括第一和第二弯曲部分的弓形段。 每个辅助支柱包括第一和第二弧。 主支柱终止于锚钩。 每个主支柱在塌缩状态下沿着纵向轴线跨越另一个主支柱，使得弓形段占据第一直径，并且锚定钩占据第二直径，第一直径大于用于过滤器取出或输送的第二直径。 在扩张状态下，副支柱将过滤器集中在血管中，并且锚钩与血管接合。