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公开(公告)号:US20210121511A1
公开(公告)日:2021-04-29
申请号:US17058565
申请日:2019-05-17
申请人: Henry C. Lin , Derek M. Lin , Britt Koskella , UNM RAINFOREST INNOVATIONS , UNIVERSITY OF CALIFORNIA, BERKELEY
发明人: Henry C. Lin , Derek M. Lin , Britt Koskella
IPC分类号: A61K35/76 , A61K31/702 , A61K31/733 , A61K35/74
摘要: A pharmaceutical composition includes a preparation of virus-like particles (VLPs) obtained from the gastrointestinal tract of a subject and a pharmaceutically-acceptable carrier. The VLPs can include bacteriophages, eukaryotic viruses, or gene transfer agents. A VLP composition may be administered to a subject having, or at risk of having dysbiosis, in an amount effective to amelio-rate at least one symptom or clinical sign of dysbiosis. A VLP composition also may be administered to a subject in preparation for administering a source of bacteria, to improve the receptivity of subject's gut to source of bacteria.