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公开(公告)号：US20080127359A1
公开(公告)日：2008-05-29
申请号：US11926610
申请日：2007-10-29
IPC分类号： C12P21/00
CPC分类号： C07K16/4208
摘要： The present invention relates to a method for generating anti-idiotypic antibodies comprising a) creating a non-human animal transgenic for an exogenous antibody, b) inducing an immune response in said transgenic non-human animal against an antibody of interest, whereby the antibody of interest comprises the same species-specific isotype as the exogenous antibody, and c) generating antibodies directed against the idiotypic part of the antibody of interest.
摘要翻译： 本发明涉及产生抗独特型抗体的方法，其包括a）产生用于外源抗体的非人动物转基因，b）在所述转基因非人动物中针对感兴趣的抗体诱导免疫应答，由此所述抗体 感兴趣的内容包括与外源性抗体相同的物种特异性同种型，以及c）产生针对感兴趣抗体的独特型部分的抗体。
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公开(公告)号：US20070006330A1
公开(公告)日：2007-01-04
申请号：US11474864
申请日：2006-06-26
IPC分类号： A01K67/027
CPC分类号： A01K67/0275 , A01K2217/05 , A01K2217/072 , A01K2267/03 , G01N33/5088
摘要： The present invention relates to methods for determining the relative immunogenicity of exogenous antibody variants comprising a) creating a non-human animal, which is transgenic for a standard antibody, b) contacting said transgenic non-human animal with an exogenous antibody whereby said exogenous antibody is a variant of said transgenic standard antibody of a), and c) determining the immune response of the transgenic non-human animal elicited by the exogenous antibody of (b).
摘要翻译： 本发明涉及确定外源性抗体变体的相对免疫原性的方法，包括a）产生对于标准抗体是转基因的非人动物，b）使所述转基因非人动物与外源性抗体接触，由此所述外源抗体 是a）的所述转基因标准抗体的变体，和c）确定由（b）的外源性抗体引起的转基因非人动物的免疫应答。
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公开(公告)号：US07332168B2
公开(公告)日：2008-02-19
申请号：US10362591
申请日：2001-08-22
申请人： Marcel Zocher , Patrick Bäeuerle , Torsten Dreier
发明人： Marcel Zocher , Patrick Bäeuerle , Torsten Dreier
CPC分类号： C07K16/28 , A61K39/0008 , C07K14/70532 , C07K16/2809 , C07K2317/34 , C07K2319/00 , C07K2319/30 , Y02A50/466
摘要： The present invention relates to a composition for the selective elimination of autoreactive B-cells comprising at least one (poly)peptide construct consisting of at least two domains wherein one of said domains comprises an autoreactive antigen or (a) fragments(s) thereof specifically recognized by the Ig receptors of said autoreactive B-cells and wherein one of said domains comprises an effector molecule capable of interacting with and/or of activating NK-cells, T-cells, macrophages, monocytes and/or granulocytes and/or capable of activating the complement system.
摘要翻译： 本发明涉及用于选择性消除自身反应性B细胞的组合物，其包含至少一种（多）肽构建体，其由至少两个结构域组成，其中所述结构域之一包含自身反应性抗原或（a）其特异性片段 由所述自身反应性B细胞的Ig受体识别，其中所述结构域之一包含能够与NK细胞，T细胞，巨噬细胞，单核细胞和/或粒细胞相互作用和/或激活的效应分子和/或能够 激活补体系统。
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公开(公告)号：US07323440B2
公开(公告)日：2008-01-29
申请号：US10503590
申请日：2003-02-12
申请人： Marcel Zocher , Torsten Dreier , Patrick Baeuerle
发明人： Marcel Zocher , Torsten Dreier , Patrick Baeuerle
IPC分类号： A61K38/16
CPC分类号： C07K16/2878 , A61K38/00 , A61K39/39 , A61K2039/55516 , A61K2039/55561 , C07K2319/00 , C07K2319/30 , Y02A50/466
摘要： The present invention relates to a (poly)peptide construct consisting of at least two domains of at least two pluralities of domains wherein one of said domains or pluralities of domains comprises a de-immunized autoreactive antigen or (a) fragment(s) thereof specifically recognized by the Ig receptors of an autoreactive B-cells and wherein a/the further domain or plurality of domains comprises an effector molecule capable of interacting with and/or of activating NK-cells, T-cells, macrophages, monocytes and/or granulocytes. Preferably, said (poly)peptide construct consisting of at least two domains comprises a de-immunized autoreactive antigen or (a) fragment which is MOG or (a) fragment(s) thereof and a second domain comprising an effector molecule is an anti-CD3 receptor or an Fc-part of an immunoglobulin. The invention also relates to compositions comprising the compounds of the invention. Described is also the use of the afore-mentioned (poly)peptide construct and further compounds for the preparation of a pharmaceutical composition for the treatment and/or prevention of an autoimmune disease. In addition, the present invention relates to method for treating, ameliorating and/or preventing of an autoimmune disease.
摘要翻译： 本发明涉及由多个结构域至少两个结构域组成的（多）肽构建体，其中所述结构域或多个结构域之一包含去免疫的自身反应性抗原或（a）其特异性片段 由自身反应性B细胞的Ig受体识别，并且其中一个或多个结构域包含能够与NK细胞，T细胞，巨噬细胞，单核细胞和/或粒细胞相互作用和/或激活的效应分子 。 优选地，由至少两个结构域组成的所述（多）肽构建体包含去免疫的自身反应性抗原或（a）作为MOG或（a）其片段的片段，并且包含效应分子的第二结构域是抗 - CD3受体或免疫球蛋白的Fc部分。 本发明还涉及包含本发明化合物的组合物。 还描述了上述（多）肽构建体和其它化合物用于制备用于治疗和/或预防自身免疫疾病的药物组合物的用途。 此外，本发明涉及治疗，改善和/或预防自身免疫性疾病的方法。
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公开(公告)号：US20060062780A1
公开(公告)日：2006-03-23
申请号：US10503590
申请日：2003-02-12
申请人： Marcel Zocher , Torsten Dreier , Patrick Baeuerle
发明人： Marcel Zocher , Torsten Dreier , Patrick Baeuerle
IPC分类号： A61K39/395 , A61K38/17 , C07K16/42 , C07K14/47 , C12P21/06
CPC分类号： C07K16/2878 , A61K38/00 , A61K39/39 , A61K2039/55516 , A61K2039/55561 , C07K2319/00 , C07K2319/30 , Y02A50/466
摘要： The present invention relates to a (poly)peptide construct consisting of at least two domains of at least two pluralities of domains wherein one of said domains or pluralities of domains comprises a de-immunized autoreactive antigen or (a) fragment(s) thereof specifically recognized by the Ig receptors of an autoreactive B-cells and wherein a/the further domain or plurality of domains comprises an effector molecule capable of interacting with and/or of activating NK-cells, T-cells, macrophages, monocytes and/or granulocytes. Preferably, said (poly)peptide construct consisting of at least two domains comprises a de-immunized autoreactive antigen or (a) fragment which is MOG or (a) fragment(s) thereof and a second domain comprising an effector molecule is an anti-CD3 receptor or an Fc-part of an immunoglobulin. The invention also relates to compositions comprising the compounds of the invention. Described is also the use of the afore-mentioned (poly)peptide construct and further compounds for the preparation of a pharmaceutical composition for the treatment and/or prevention of an autoimmune disease. In addition, the present invention relates to method for treating, ameliorating and/or preventing of an autoimmune disease.
摘要翻译： 本发明涉及由多个结构域至少两个结构域组成的（多）肽构建体，其中所述结构域或多个结构域之一包含去免疫的自身反应性抗原或（a）其特异性片段 由自身反应性B细胞的Ig受体识别，并且其中一个或多个结构域包含能够与NK细胞，T细胞，巨噬细胞，单核细胞和/或粒细胞相互作用和/或激活的效应分子 。 优选地，由至少两个结构域组成的所述（多）肽构建体包含去免疫的自身反应性抗原或（a）作为MOG或（a）其片段的片段，并且包含效应分子的第二结构域是抗 - CD3受体或免疫球蛋白的Fc部分。 本发明还涉及包含本发明化合物的组合物。 还描述了上述（多）肽构建体和其它化合物用于制备用于治疗和/或预防自身免疫疾病的药物组合物的用途。 此外，本发明涉及治疗，改善和/或预防自身免疫性疾病的方法。
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