-
1.发明授权Pharmaceutical compositions comprising lignans and their derivatives for treating hyperplastic diseases 有权包含用于治疗增生性疾病的木脂素及其衍生物的药物组合物公开(公告)号：US08765804B2
公开(公告)日：2014-07-01
申请号：US13054385
申请日：2009-07-17
IPC分类号： A01N43/08 , A61K31/34 , A01N43/06 , A61K31/38 , C07D333/00 , C07D409/00 , C07D317/00 , C07D323/02 , C07D317/70
CPC分类号： A61K31/341
摘要： The present invention relates to a pharmaceutical composition comprising specific compounds which may be obtained from Leontopodium alpinum Cass. (Edelweiss). A preferred compound is leoligin (=(2S,3R,4R)-4-(3,4-dimethoxybenzyl) -2-(3,4-dimethoxyphenyl)tetrahydrofuran-3-yl]methyl(2Z)-2-methylbut-2-enoat]). Corresponding means and methods in respect of medical uses of the compounds are described. The present invention also provides a medical device comprising, containing or having been contacted with the compound. The compounds provided herein may particularly be used in the treatment of hyperplastic diseases, in particular intimal hyperplasia, e.g. stenosis, restenosis, atherosclerosis and the like. Also envisaged herein is the use of these compounds in the treatment of proliferative diseases, such as leukemia, prostate cancer and lung cancer.
摘要翻译： 本发明涉及一种药物组合物，其包含可从Leontopodium alpinum Cass获得的特定化合物。 （Edelweiss）。 优选的化合物是leoligin（=（2S，3R，4R）-4-（3,4-二甲氧基苄基）-2-（3,4-二甲氧基苯基）四氢呋喃-3-基]甲基（2Z）-2-甲基丁-2- -enoat]）。 描述了关于化合物的医疗用途的相应手段和方法。 本发明还提供了包含或含有该化合物的医疗装置。 本文提供的化合物可特别用于治疗增生性疾病，特别是内膜增生，例如内膜增生。 狭窄，再狭窄，动脉粥样硬化等。 本文还设想使用这些化合物来治疗增殖性疾病，例如白血病，前列腺癌和肺癌。
-
2.发明申请PHARMACEUTICAL COMPOSITIONS COMPRISING LIGNANS AND THEIR DERIVATIVES FOR TREATING HYPERPLASTIC DISEASES 有权包含LIGNANS及其用于治疗高血压疾病的衍生物的药物组合物公开(公告)号：US20110189252A1
公开(公告)日：2011-08-04
申请号：US13054385
申请日：2009-07-17
IPC分类号： A61K9/00 , A61K31/341 , A61K31/381 , A61K31/40 , A01N1/02 , A61P35/00
CPC分类号： A61K31/341
摘要： The present invention relates to a pharmaceutical composition comprising specific compounds which may be obtained from Leontopodium alpinum Cass. (Edelweiss). A preferred compound is leoligin (=(2S,3R,4R)-4-(3,4-dimethoxybenzyl)-2-(3,4-dimethoxyphenyl)tetrahydrofuran-3-yl]methyl(2Z)-2-methylbut-2-enoat]). Corresponding means and methods in respect of medical uses of the compounds are described. The present invention also provides a medical device comprising, containing or having been contacted with the compound. The compounds provided herein may particularly be used in the treatment of hyperplastic diseases, in particular intimal hyperplasia, e.g. stenosis, restenosis, atherosclerosis and the like. Also envisaged herein is the use of these compounds in the treatment of proliferative diseases, such as leukemia, prostate cancer and lung cancer.
摘要翻译： 本发明涉及一种药物组合物，其包含可从Leontopodium alpinum Cass获得的特定化合物。 （Edelweiss）。 优选的化合物是leoligin（=（2S，3R，4R）-4-（3,4-二甲氧基苄基）-2-（3,4-二甲氧基苯基）四氢呋喃-3-基]甲基（2Z）-2-甲基丁-2- -enoat]）。 描述了关于化合物的医疗用途的相应手段和方法。 本发明还提供了包含或含有该化合物的医疗装置。 本文提供的化合物可特别用于治疗增生性疾病，特别是内膜增生，例如内膜增生。 狭窄，再狭窄，动脉粥样硬化等。 本文还设想使用这些化合物来治疗增殖性疾病，例如白血病，前列腺癌和肺癌。
-
公开(公告)号：US20130053438A1
公开(公告)日：2013-02-28
申请号：US13521016
申请日：2011-01-19
IPC分类号： A61K31/341 , A61P9/00 , A61P17/00 , A61P9/10 , A61P27/02 , A61P15/10 , A61P7/02 , A61P9/08 , A61P11/00 , C07D307/16 , A61P25/28
CPC分类号： A61K31/341
摘要： The present invention relates to a pharmaceutical composition for stimulating angiogenesis and/or the treatment or prevention of hypovascularity and/or the prevention and/or treatment of an angiogenic disorder/disease, whereby the composition comprises specific compounds which may be obtained from Leontopodium alpinum Cass, (Edelweiss). These compounds relate to lignan compounds as shown in herein disclosed formula I. A preferred compound in this context is leologin—IUPAC name [(2S,3R,4R)-4-(3,4-dimethoxybenzyl)-2-(3,4-dimethoxyphenyl)tetxahydrofuran-3-yl]methyl (2Z)-2-methylbut-2-enoat], and even more particularly 5-methoxy-leoligin (IUPAC name: [(25,3R,4R)-4-(3,4-dimethoxybenzyl)-2-(3,4,5-trimethoxyphenyl)tetrahydrofuran-3-yl]methyl-(2Z)-2-methylbut-2-enoat) and derivatives thereof. Corresponding means and methods in respect of medical uses of these compounds are described. The compounds provided herein may particularly be useful in the treatment of wound healing, in particular traumatic wounds (like, but not limited to surface and skin wounds), non-diabetic retinopathy, vascular obliteration. The compounds derived from Leontopodium alpinum Cass. (Edelweiss) as described herein are also useful in the re-vascularization of tissue after amputation as well during or after transplantation of tissues or organs. These compounds are also useful in the medical intervention of arterio- and veno-microvasculopathy of blood vessels, in particular retinal microvasculopathy, arterio- and veno-microangiopathy that preferably cannot be treated by surgery, in ischemic diseases or ischemic disorders or in the treatment or prevention of necrosis/necrotic events, in particular of ischemic diseases or necrosis/necrotic events that cannot be treated by surgery. These compounds may also be used in the treatment or prevention of stable angina abdominalis, vascular dementia, impotence or penile dysfunction and the like and they may be employed in the reactivation of necrotisising tissue or in the reactivation of hibernating tissue.
-
-
搜索结果
3 条记录 (耗时 0.02 秒)
