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    PHARMACEUTICAL COMPOSITIONS COMPRISING LIGNANS AND THEIR DERIVATIVES FOR THE MEDICAL MANAGEMENT OF ANGIOGENESIS AND HYPOVASCULARITY
    1.
    发明申请
    PHARMACEUTICAL COMPOSITIONS COMPRISING LIGNANS AND THEIR DERIVATIVES FOR THE MEDICAL MANAGEMENT OF ANGIOGENESIS AND HYPOVASCULARITY 审中-公开

    公开(公告)号：US20130053438A1

    公开(公告)日：2013-02-28

    申请号：US13521016

    申请日：2011-01-19

    申请人： David Bernhard ,  Hermann Stuppner ,  Stefan Schwaiger ,  Dominik Wiedemann ,  Gerold Untergasser

    发明人： David Bernhard ,  Hermann Stuppner ,  Stefan Schwaiger ,  Dominik Wiedemann ,  Gerold Untergasser

    IPC分类号： A61K31/341 ,  A61P9/00 ,  A61P17/00 ,  A61P9/10 ,  A61P27/02 ,  A61P15/10 ,  A61P7/02 ,  A61P9/08 ,  A61P11/00 ,  C07D307/16 ,  A61P25/28

    CPC分类号： A61K31/341

    摘要： The present invention relates to a pharmaceutical composition for stimulating angiogenesis and/or the treatment or prevention of hypovascularity and/or the prevention and/or treatment of an angiogenic disorder/disease, whereby the composition comprises specific compounds which may be obtained from Leontopodium alpinum Cass, (Edelweiss). These compounds relate to lignan compounds as shown in herein disclosed formula I. A preferred compound in this context is leologin—IUPAC name [(2S,3R,4R)-4-(3,4-dimethoxybenzyl)-2-(3,4-dimethoxyphenyl)tetxahydrofuran-3-yl]methyl (2Z)-2-methylbut-2-enoat], and even more particularly 5-methoxy-leoligin (IUPAC name: [(25,3R,4R)-4-(3,4-dimethoxybenzyl)-2-(3,4,5-trimethoxyphenyl)tetrahydrofuran-3-yl]methyl-(2Z)-2-methylbut-2-enoat) and derivatives thereof. Corresponding means and methods in respect of medical uses of these compounds are described. The compounds provided herein may particularly be useful in the treatment of wound healing, in particular traumatic wounds (like, but not limited to surface and skin wounds), non-diabetic retinopathy, vascular obliteration. The compounds derived from Leontopodium alpinum Cass. (Edelweiss) as described herein are also useful in the re-vascularization of tissue after amputation as well during or after transplantation of tissues or organs. These compounds are also useful in the medical intervention of arterio- and veno-microvasculopathy of blood vessels, in particular retinal microvasculopathy, arterio- and veno-microangiopathy that preferably cannot be treated by surgery, in ischemic diseases or ischemic disorders or in the treatment or prevention of necrosis/necrotic events, in particular of ischemic diseases or necrosis/necrotic events that cannot be treated by surgery. These compounds may also be used in the treatment or prevention of stable angina abdominalis, vascular dementia, impotence or penile dysfunction and the like and they may be employed in the reactivation of necrotisising tissue or in the reactivation of hibernating tissue.

    Pharmaceutical compositions comprising lignans and their derivatives for treating hyperplastic diseases
    2.
    发明授权
    Pharmaceutical compositions comprising lignans and their derivatives for treating hyperplastic diseases 有权
    包含用于治疗增生性疾病的木脂素及其衍生物的药物组合物

    公开(公告)号：US08765804B2

    公开(公告)日：2014-07-01

    申请号：US13054385

    申请日：2009-07-17

    申请人： Hermann Stuppner ,  Stefan Schwaiger ,  David Bernhard ,  Günther Laufer

    发明人： Hermann Stuppner ,  Stefan Schwaiger ,  David Bernhard ,  Günther Laufer

    IPC分类号： A01N43/08 ,  A61K31/34 ,  A01N43/06 ,  A61K31/38 ,  C07D333/00 ,  C07D409/00 ,  C07D317/00 ,  C07D323/02 ,  C07D317/70

    CPC分类号： A61K31/341

    摘要： The present invention relates to a pharmaceutical composition comprising specific compounds which may be obtained from Leontopodium alpinum Cass. (Edelweiss). A preferred compound is leoligin (=(2S,3R,4R)-4-(3,4-dimethoxybenzyl) -2-(3,4-dimethoxyphenyl)tetrahydrofuran-3-yl]methyl(2Z)-2-methylbut-2-enoat]). Corresponding means and methods in respect of medical uses of the compounds are described. The present invention also provides a medical device comprising, containing or having been contacted with the compound. The compounds provided herein may particularly be used in the treatment of hyperplastic diseases, in particular intimal hyperplasia, e.g. stenosis, restenosis, atherosclerosis and the like. Also envisaged herein is the use of these compounds in the treatment of proliferative diseases, such as leukemia, prostate cancer and lung cancer.

    摘要翻译： 本发明涉及一种药物组合物，其包含可从Leontopodium alpinum Cass获得的特定化合物。 （Edelweiss）。 优选的化合物是leoligin（=（2S，3R，4R）-4-（3,4-二甲氧基苄基）-2-（3,4-二甲氧基苯基）四氢呋喃-3-基]甲基（2Z）-2-甲基丁-2- -enoat]）。 描述了关于化合物的医疗用途的相应手段和方法。 本发明还提供了包含或含有该化合物的医疗装置。 本文提供的化合物可特别用于治疗增生性疾病，特别是内膜增生，例如内膜增生。 狭窄，再狭窄，动脉粥样硬化等。 本文还设想使用这些化合物来治疗增殖性疾病，例如白血病，前列腺癌和肺癌。

    PHARMACEUTICAL COMPOSITIONS COMPRISING LIGNANS AND THEIR DERIVATIVES FOR TREATING HYPERPLASTIC DISEASES
    3.
    发明申请
    PHARMACEUTICAL COMPOSITIONS COMPRISING LIGNANS AND THEIR DERIVATIVES FOR TREATING HYPERPLASTIC DISEASES 有权
    包含LIGNANS及其用于治疗高血压疾病的衍生物的药物组合物

    公开(公告)号：US20110189252A1

    公开(公告)日：2011-08-04

    申请号：US13054385

    申请日：2009-07-17

    申请人： Hermann Stuppner ,  Stefan Schwaiger ,  David Bernhard ,  Günther Laufer

    发明人： Hermann Stuppner ,  Stefan Schwaiger ,  David Bernhard ,  Günther Laufer

    IPC分类号： A61K9/00 ,  A61K31/341 ,  A61K31/381 ,  A61K31/40 ,  A01N1/02 ,  A61P35/00

    CPC分类号： A61K31/341

    摘要： The present invention relates to a pharmaceutical composition comprising specific compounds which may be obtained from Leontopodium alpinum Cass. (Edelweiss). A preferred compound is leoligin (=(2S,3R,4R)-4-(3,4-dimethoxybenzyl)-2-(3,4-dimethoxyphenyl)tetrahydrofuran-3-yl]methyl(2Z)-2-methylbut-2-enoat]). Corresponding means and methods in respect of medical uses of the compounds are described. The present invention also provides a medical device comprising, containing or having been contacted with the compound. The compounds provided herein may particularly be used in the treatment of hyperplastic diseases, in particular intimal hyperplasia, e.g. stenosis, restenosis, atherosclerosis and the like. Also envisaged herein is the use of these compounds in the treatment of proliferative diseases, such as leukemia, prostate cancer and lung cancer.

    摘要翻译： 本发明涉及一种药物组合物，其包含可从Leontopodium alpinum Cass获得的特定化合物。 （Edelweiss）。 优选的化合物是leoligin（=（2S，3R，4R）-4-（3,4-二甲氧基苄基）-2-（3,4-二甲氧基苯基）四氢呋喃-3-基]甲基（2Z）-2-甲基丁-2- -enoat]）。 描述了关于化合物的医疗用途的相应手段和方法。 本发明还提供了包含或含有该化合物的医疗装置。 本文提供的化合物可特别用于治疗增生性疾病，特别是内膜增生，例如内膜增生。 狭窄，再狭窄，动脉粥样硬化等。 本文还设想使用这些化合物来治疗增殖性疾病，例如白血病，前列腺癌和肺癌。

    Composition and process for ashless removal of post-etch photoresist and/or bottom anti-reflective material on a substrate
    6.
    发明申请
    Composition and process for ashless removal of post-etch photoresist and/or bottom anti-reflective material on a substrate 审中-公开
    用于在基底上无蚀刻去除蚀刻后光致抗蚀剂和/或底部抗反射材料的组合物和方法

    公开(公告)号：US20060063687A1

    公开(公告)日：2006-03-23

    申请号：US10944491

    申请日：2004-09-17

    申请人： David Minsek ,  David Bernhard ,  Thomas Baum

    发明人： David Minsek ,  David Bernhard ,  Thomas Baum

    IPC分类号： C11D7/32

    CPC分类号： C11D7/3209 ,  C11D11/0047 ,  C23C22/63 ,  C23G1/20

    摘要： An aqueous-based composition and process for removing photoresist and/or bottom anti-reflective coating (BARC) material from a substrate having such material(s) thereon. The aqueous-based composition includes a quaternary ammonium base, at least one co-solvent, and optionally a chelator. The composition achieves high-efficiency removal of photoresist and/or BARC material in the manufacture of integrated circuitry without adverse effect on metal species on the substrate, such as copper, and without damage to SiOC-based dielectric materials employed in the semiconductor architecture.

    摘要翻译： 一种用于从其上具有这种材料的基材去除光致抗蚀剂和/或底部抗反射涂层（BARC）材料的水基组合物和方法。 水基组合物包括季铵碱，至少一种共溶剂和任选的螯合剂。 该组合物在集成电路的制造中实现了光致抗蚀剂和/或BARC材料的高效去除，而对衬底（例如铜）上的金属物质没有不利影响，并且不损坏半导体结构中使用的基于SiOC的介电材料。