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1.发明申请Methods for the treatment and prevention of abnormal cell proliferation using TACI-fusion molecules 有权使用TACI-融合分子治疗和预防异常细胞增殖的方法公开(公告)号：US20070207156A1
公开(公告)日：2007-09-06
申请号：US11501999
申请日：2006-08-09
Applicant: Herve Broly , Arnaud Ythier , Eric Sievers
Inventor： Herve Broly , Arnaud Ythier , Eric Sievers
IPC: A61K39/395 , C07K16/30
CPC classification number: C07K14/70578 , A61K38/00 , C07K2319/30
Abstract: The present invention provides methods and compositions for treatment of hyperproliferative disorders and cancers, including multiple myeloma and Waldenström's macroglobulinemia, comprising administering to a patient in need of the treatment a TACI-Ig fusion molecule in amount sufficient to suppress proliferation-inducing functions of BlyS and APRIL.
Abstract translation: 本发明提供了用于治疗过度增殖性疾病和癌症的方法和组合物，包括多发性骨髓瘤和瓦尔登斯特伦的巨球蛋白血症，包括给予需要治疗TACI-Ig融合分子的量足以抑制BlyS的增殖诱导功能和 四月。
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2.发明授权Methods for treating B-cell malignancies using a TACI-Ig fusion molecule 有权使用TACI-Ig融合分子治疗B细胞恶性肿瘤的方法公开(公告)号：US07842292B2
公开(公告)日：2010-11-30
申请号：US11502134
申请日：2006-08-09
Applicant: Herve Broly , Arnaud Ythier , Eric Sievers , Sharon J. Busby , Jan Öhrström , Ivan Nestorov , Stephen M. Ansell
Inventor： Herve Broly , Arnaud Ythier , Eric Sievers , Sharon J. Busby , Jan Öhrström , Ivan Nestorov , Stephen M. Ansell
IPC: A61K39/395
CPC classification number: A61K49/0008 , A61K38/177 , A61K47/6835 , C07K2319/30
Abstract: The present invention provides methods and compositions for treatment of B-cell malignancies, including non-Hodgkin's lymphoma, comprising administering to a patient in need of the treatment a TACI-Ig fusion molecule in amount sufficient to suppress proliferation-inducing functions of BlyS and APRIL.
Abstract translation: 本发明提供了用于治疗B细胞恶性肿瘤（包括非霍奇金淋巴瘤）的方法和组合物，其包括向需要治疗的患者施用足以抑制BlyS和APRIL增殖诱导功能的TACI-Ig融合分子 。
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Patent Agency Ranking
3.发明授权Methods for the treatment and prevention of abnormal cell proliferation using TACI-fusion molecules 有权使用TACI-融合分子治疗和预防异常细胞增殖的方法公开(公告)号：US08808696B2
公开(公告)日：2014-08-19
申请号：US11501999
申请日：2006-08-09
Applicant: Herve Broly , Arnaud Ythier , Eric Sievers
Inventor： Herve Broly , Arnaud Ythier , Eric Sievers
IPC: A61K39/395
CPC classification number: C07K14/70578 , A61K38/00 , C07K2319/30
Abstract: The present invention provides methods and compositions for treatment of hyperproliferative disorders and cancers, including multiple myeloma and Waldenström's macroglobulinemia, comprising administering to a patient in need of the treatment a TACI-Ig fusion molecule in amount sufficient to suppress proliferation-inducing functions of BlyS and APRIL.
Abstract translation: 本发明提供了用于治疗过度增殖性疾病和癌症的方法和组合物，包括多发性骨髓瘤和瓦尔登斯特伦的巨球蛋白血症，包括给予需要治疗TACI-Ig融合分子的量足以抑制BlyS的增殖诱导功能和 四月。
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4.发明申请Methods for treating B-cell malignancies using a TACI-Ig fusion molecule 有权使用TACI-Ig融合分子治疗B细胞恶性肿瘤的方法公开(公告)号：US20070071760A1
公开(公告)日：2007-03-29
申请号：US11502134
申请日：2006-08-09
Applicant: Herve Broly , Arnaud Ythier , Eric Sievers , Sharon Busby , Jan Ohrstrom , Ivan Nestorov , Stephen Ansell
Inventor： Herve Broly , Arnaud Ythier , Eric Sievers , Sharon Busby , Jan Ohrstrom , Ivan Nestorov , Stephen Ansell
IPC: A61K39/395
CPC classification number: A61K49/0008 , A61K38/177 , A61K47/6835 , C07K2319/30
Abstract: The present invention provides methods and compositions for treatment of B-cell malignancies, including non-Hodgkin's lymphoma, comprising administering to a patient in need of the treatment a TACI-Ig fusion molecule in amount sufficient to suppress proliferation-inducing functions of BlyS and APRIL.
Abstract translation: 本发明提供了用于治疗B细胞恶性肿瘤（包括非霍奇金淋巴瘤）的方法和组合物，其包括向需要治疗的患者施用足以抑制BlyS和APRIL增殖诱导功能的TACI-Ig融合分子 。
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公开(公告)号：US08377903B2
公开(公告)日：2013-02-19
申请号：US12766173
申请日：2010-04-23
Applicant: Giampiero De Luca , Arnaud Ythier , Alain Munafo , Maria Lopez-Bresnahan
Inventor： Giampiero De Luca , Arnaud Ythier , Alain Munafo , Maria Lopez-Bresnahan
IPC: A61K31/52 , A61K31/7076 , A61K38/21 , A61K9/00
CPC classification number: A61K38/21 , A61K31/7076 , A61K38/215 , A61K2300/00
Abstract: The present invention is related to the use of Cladribine for the preparation of a pharmaceutical formulation for the treatment of multiple sclerosis, especially relapsing-remitting multiple sclerosis or early secondary progressive multiple sclerosis, wherein the preparation is to be the orally administered and wherein re-treatments are possible.
Abstract translation: 本发明涉及克拉屈滨用于制备用于治疗多发性硬化，特别是复发性多发性硬化症或早期继发性进行性多发性硬化症的药物制剂的用途，其中所述制剂是口服给药， 治疗是可能的。
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公开(公告)号：US20100203017A1
公开(公告)日：2010-08-12
申请号：US12766173
申请日：2010-04-23
Applicant: Giampiero De Luca , Arnaud Ythier , Alain Munafo , Maria Lopez-Bresnahan
Inventor： Giampiero De Luca , Arnaud Ythier , Alain Munafo , Maria Lopez-Bresnahan
IPC: A61K31/7076 , A61K38/21 , A61P25/00
CPC classification number: A61K38/21 , A61K31/7076 , A61K38/215 , A61K2300/00
Abstract: The present invention is related to the use of Cladribine for the preparation of a pharmaceutical formulation for the treatment of multiple sclerosis, especially relapsing-remitting multiple sclerosis or early secondary progressive multiple sclerosis, wherein the preparation is to be the orally administered and wherein re-treatments are possible.
Abstract translation: 本发明涉及克拉屈滨用于制备用于治疗多发性硬化，特别是复发性多发性硬化症或早期继发性进行性多发性硬化症的药物制剂的用途，其中所述制剂是口服给药， 治疗是可能的。
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公开(公告)号：US07713947B2
公开(公告)日：2010-05-11
申请号：US11722018
申请日：2005-12-20
Applicant: Giampiero De Luca , Arnaud Ythier , Alain Munafo , Maria Lopez-Bresnahan
Inventor： Giampiero De Luca , Arnaud Ythier , Alain Munafo , Maria Lopez-Bresnahan
IPC: A61K31/52 , A61K31/7076 , A61K38/21 , A61K9/00
CPC classification number: A61K38/21 , A61K31/7076 , A61K38/215 , A61K2300/00
Abstract: The present invention is related to the use of Cladribine for the preparation of a pharmaceutical formulation for the treatment of multiple sclerosis, especially relapsing-remitting multiple sclerosis or early secondary progressive multiple sclerosis, wherein the preparation is to be orally administered and wherein re-treatments are possible.
Abstract translation: 本发明涉及克拉屈滨用于制备用于治疗多发性硬化，特别是复发性多发性硬化症或早期继发性进行性多发性硬化症的药物制剂的用途，其中所述制剂将被口服给药，并且其中再次治疗 是可能的
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