公开(公告)号：US09624172B2

公开(公告)日：2017-04-18

申请号：US15119294

申请日：2015-02-13

Applicant: Hetero Research Foundation

Inventor： Bandi Parthasaradhi Reddy ,  Kura Rathnakar Reddy ,  Dasari Muralidhara Reddy ,  Jambula Mukunda Reddy ,  Bandi Vamsi Krishna

IPC: C07D211/58

CPC classification number: C07D211/58

Abstract: The present invention provides novel polymorphs of Lomitapide, process for their preparation and pharmaceutical compositions comprising them. The present invention also provides a novel polymorph of Lomitapide mesylate, process for its preparation and pharmaceutical compositions comprising it.

公开(公告)号：US10934251B2

公开(公告)日：2021-03-02

申请号：US16797498

申请日：2020-02-21

Applicant: Hetero Research Foundation

Inventor： Bandi Parthasaradhi Reddy ,  Kura Rathnakar Reddy ,  Bandi Vamsi Krishna ,  Jambula Mukunda Reddy

IPC: C07C231/02 ,  C07D211/58 ,  C07C231/12 ,  C07C67/293 ,  C07C69/157 ,  C07C51/367 ,  C07C62/32

Abstract: The present invention relates to a process for preparing Lomitapide or its pharmaceutically acceptable salt thereof having high purity with acceptable levels of impurities.

公开(公告)号：US10023526B2

公开(公告)日：2018-07-17

申请号：US15524391

申请日：2015-11-04

Applicant: HETERO RESEARCH FOUNDATION

Inventor： Bandi Parthasaradhi Reddy ,  Kura Rathnakar Reddy ,  Bandi Vamsi Krishna ,  Jambula Mukunda Reddy

IPC: C07C231/02 ,  C07C231/12 ,  C07D211/58 ,  C07C67/293 ,  C07C69/157 ,  C07C51/367 ,  C07C62/32

Abstract: The present invention relates to a process for preparing Lomitapide or its pharmaceutically acceptable salt thereof having high purity with acceptable levels of impurities.

公开(公告)号：US20170057917A1

公开(公告)日：2017-03-02

申请号：US15119294

申请日：2015-02-13

Applicant: Hetero Research Foundation

Inventor： Bandi Parthasaradhi Reddy ,  Kura Rathnakar Reddy ,  Dasari Muralidhara Reddy ,  Jambula Mukunda Reddy ,  Bandi Vamsi Krishna

IPC: C07D211/58

CPC classification number: C07D211/58

Abstract: The present invention provides novel polymorphs of Lomitapide, process for their preparation and pharmaceutical compositions comprising them. The present invention also provides a novel polymorph of Lomitapide mesylate, process for its preparation and pharmaceutical compositions comprising it.

Abstract translation: 本发明提供了洛米他滨的新型多晶型物，其制备方法和包含它们的药物组合物。 本发明还提供了甲磺酸洛美哌啶的新型多晶型物，其制备方法和包含它的药物组合物。