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公开(公告)号：US08722663B2
公开(公告)日：2014-05-13
申请号：US13318053
申请日：2011-01-28
申请人： Hideki Takasu , Shigekazu Fujita , Shinya Ohtsuka , Toshiyuki Hirose , Yosuke Sato , Satoshi Yamada , Keisuke Miyajima , Koji Sakai , Yutaka Kojima , Kazuo Sekiguchi , Yasuo Yanagihara , Takashi Suzuki , Hideo Tanaka , Kazuhisa Sugiyama , Mitsuhiro Okuno , Takumi Sumida
发明人： Hideki Takasu , Shigekazu Fujita , Shinya Ohtsuka , Toshiyuki Hirose , Yosuke Sato , Satoshi Yamada , Keisuke Miyajima , Koji Sakai , Yutaka Kojima , Kazuo Sekiguchi , Yasuo Yanagihara , Takashi Suzuki , Hideo Tanaka , Kazuhisa Sugiyama , Mitsuhiro Okuno , Takumi Sumida
IPC分类号： A61K31/44 , A61K31/4439 , A61K31/4545 , A61K31/4725 , A61K31/443 , A61K31/496 , A61K31/551 , A61K31/553 , C07D213/69 , C07D401/12 , C07D405/12 , C07D413/12
CPC分类号： C07D213/69 , C07D401/12 , C07D405/12 , C07D413/12 , C07D417/12
摘要： The present invention provides a novel compound having an excellent antitumor effect. The compound of the present invention is represented by the following general formula (1) wherein R1 and R2 are aryl or the like; A is lower alkylene; Ring X is optionally substituted arylene; E is bond or lower alkenylene; Ring Y is optionally substituted heterocycloalkylene containing one or more nitrogen atoms, one of which is attached to the adjacent carbonyl group; G is —NH-G2-, —N(lower alkyl)-G2-, —NH—CH2-G2-, —N(lower alkyl)-CH2-G2- or —CH2-G2-, [wherein G2 binds to R2, G2-R2 is bond-R2, phenylene-G3-R2, phenylene-G4-O—R2, phenylene-G5-NH—R2, phenylene-G6-N(lower alkyl)-R2 or quinolinediyl-O—R2, the phenylene of said phenylene-containing groups being optionally substituted with one or more substituents; G3-R2 is —O-lower alkylene-R2 or the like; G4-O— is lower alkylene-O— or the like; G5 is lower alkylene; G6 is lower alkylene].
摘要翻译： 本发明提供具有优异抗肿瘤效果的新型化合物。 本发明的化合物由以下通式（1）表示，其中R 1和R 2是芳基等; A是低级亚烷基; 环X是任选取代的亚芳基; E是键或低级亚烯基; 环Y是含有一个或多个氮原子的任选取代的杂环亚烷基，其中一个氮原子连接到相邻的羰基上; G是-NH-G2-，-N（低级烷基）-G2-，-NH-CH2-G2-，-N（低级烷基）-CH2-G2-或-CH2-G2-，其中G2与R2结合 ，G2-R2是键-R2，亚苯基-G3-R2，亚苯基-G4-O-R2，亚苯基-G5-NH-R2，亚苯基-G6-N（低级烷基）-R2或喹啉二基-O-R2， 所述含亚苯基的亚苯基任选被一个或多个取代基取代; G3-R2是-O-低级亚烷基-R2等; G4-O-是低级亚烷基-O-等; G5为低级亚烷基; G6为低级亚烷基]。
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公开(公告)号：US20120283242A1
公开(公告)日：2012-11-08
申请号：US13318053
申请日：2011-01-28
申请人： Hideki Takasu , Shigekazu Fujita , Shinya Ohtsuka , Toshiyuki Hirose , Yosuke Sato , Satoshi Yamada , Keisuke Miyajima , Koji Sakai , Yutaka Kojima , Kazuo Sekiguchi , Yasuo Yanagihara , Takashi Suzuki , Hideo Tanaka , Kazuhisa Sugiyama , Mitsuhiro Okuno , Takumi Sumida
发明人： Hideki Takasu , Shigekazu Fujita , Shinya Ohtsuka , Toshiyuki Hirose , Yosuke Sato , Satoshi Yamada , Keisuke Miyajima , Koji Sakai , Yutaka Kojima , Kazuo Sekiguchi , Yasuo Yanagihara , Takashi Suzuki , Hideo Tanaka , Kazuhisa Sugiyama , Mitsuhiro Okuno , Takumi Sumida
IPC分类号： A61K31/496 , C07D401/14 , C07D405/14 , A61K31/551 , A61P35/00 , A61K31/4545 , C07D413/14 , C07D413/12 , A61K31/553 , C07D401/12 , C07D417/14
CPC分类号： C07D213/69 , C07D401/12 , C07D405/12 , C07D413/12 , C07D417/12
摘要： The present invention provides a novel compound having an excellent antitumor effect. The compound of the present invention is represented by the following general formula (1) wherein R1 and R2 are aryl or the like; A is lower alkylene; Ring X is optionally substituted arylene; E is bond or lower alkenylene; Ring Y is optionally substituted heterocycloalkylene containing one or more nitrogen atoms, one of which is attached to the adjacent carbonyl group; G is —NH-G2-, —N(lower alkyl)-G2-, —NH—CH2-G2-, —N(lower alkyl)-CH2-G2- or —CH2-G2-, [wherein G2 binds to R2, G2-R2 is bond-R2, phenylene-G3-R2, phenylene-G4-O—R2, phenylene-G5-NH—R2, phenylene-G6-N(lower alkyl)-R2 or quinolinediyl-O—R2, the phenylene of said phenylene-containing groups being optionally substituted with one or more substituents; G3-R2 is —O-lower alkylene-R2 or the like; G4-O— is lower alkylene-O— or the like; G5 is lower alkylene; G6 is lower alkylene].
摘要翻译： 本发明提供具有优异抗肿瘤效果的新型化合物。 本发明的化合物由以下通式（1）表示，其中R 1和R 2是芳基等; A是低级亚烷基; 环X是任选取代的亚芳基; E是键或低级亚烯基; 环Y是含有一个或多个氮原子的任选取代的杂环亚烷基，其中一个氮原子连接到相邻的羰基上; G是-NH-G2-，-N（低级烷基）-G2-，-NH-CH2-G2-，-N（低级烷基）-CH2-G2-或-CH2-G2-，其中G2与R2结合 ，G2-R2是键-R2，亚苯基-G3-R2，亚苯基-G4-O-R2，亚苯基-G5-NH-R2，亚苯基-G6-N（低级烷基）-R2或喹啉二基-O-R2， 所述含亚苯基的亚苯基任选被一个或多个取代基取代; G3-R2是-O-低级亚烷基-R2等; G4-O-是低级亚烷基-O-等; G5为低级亚烷基; G6为低级亚烷基]。
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公开(公告)号：US07626483B2
公开(公告)日：2009-12-01
申请号：US11596746
申请日：2005-08-10
申请人： Shinya Ohtsuka , Masayuki Hikita
发明人： Shinya Ohtsuka , Masayuki Hikita
CPC分类号： H01G2/16 , H01C7/12 , H01H87/00 , H01M2/34 , H01M2200/00 , H01M2200/103 , Y02T10/7022 , Y10T29/49107
摘要： A self-recovering current limiting fuse protecting a secondary battery having a high rated voltage thanks to its improved breakdown voltage, expanding the application range, shortening the charging time, and realizing maintenance-free. The self-recovering current limiting fuse is made by fluid-dispersing solid conductive particles into a liquid matrix between electrodes. A current limiting operation through evaporation/spreading of the solid conductive particles and a conducting state brought about through collection of the solid conductive particles between the electrodes by dielectrophoretic force of the solid conductive particles are realized repeatedly, and a current limiting operation through evaporation/spreading of the solid conductive particles by overcurrent is realized.
摘要翻译： 自恢复电流限制熔断器保护具有高额定电压的二次电池，由于其提高了击穿电压，扩大了应用范围，缩短了充电时间，并实现了免维护。 自恢复限流熔断器通过将固体导电颗粒流体分散到电极之间的液体基质中而制成。 重复地实现通过固体导电颗粒的蒸发/扩散的电流限制操作和通过固体导电颗粒的介电电导力在电极之间收集固体导电颗粒而导致的导电状态，并且通过蒸发/扩散 实现了过电流的固体导电颗粒。
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公开(公告)号：US20070241856A1
公开(公告)日：2007-10-18
申请号：US11596746
申请日：2005-08-10
申请人： Shinya Ohtsuka , Masayuki Hikita
发明人： Shinya Ohtsuka , Masayuki Hikita
IPC分类号： H01H85/041
CPC分类号： H01G2/16 , H01C7/12 , H01H87/00 , H01M2/34 , H01M2200/00 , H01M2200/103 , Y02T10/7022 , Y10T29/49107
摘要： A self-recovering current limiting fuse protecting a secondary battery having a high rated voltage thaks to its improved breakdown voltage, expanding the application range, shortening the charging time, and realizing maintenance-free. The self-recovering current limiting fuse is made by fluid-dispersing solid conductive particles into a liquid matrix between electrodes. A current limiting operation through evaporation/spreading of the solid conductive particles and a conducting state brought about through collection of the solid conductive particles between the electrodes by dielectrophoretic force of the solid conductive particles are realized repeatedly, and a current limiting operation through evaporation/spreading of the solid conductive particles by overcurrent is realized.
摘要翻译： 保护具有高额定电压的二次电池的自恢复限流熔断器可以提高其击穿电压，扩大应用范围，缩短充电时间，实现免维护。 自恢复限流熔断器通过将固体导电颗粒流体分散到电极之间的液体基质中而制成。 重复地实现通过固体导电颗粒的蒸发/扩散的电流限制操作和通过固体导电颗粒的介电电导力在电极之间收集固体导电颗粒而导致的导电状态，并且通过蒸发/扩散 实现了过电流的固体导电颗粒。
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公开(公告)号：US08299887B2
公开(公告)日：2012-10-30
申请号：US12741464
申请日：2008-10-20
IPC分类号： H01H85/055
摘要： A liquid matrix of a nonmagnetic material is accommodated within an insulative container of a nonmagnetic material, and a pair of electrodes is disposed within the insulative container such that the electrodes face each other via the liquid matrix. Conductive particles are fluidly dispersed in the liquid matrix. A magnetic field generation section is provided externally of the insulative container so as to generate a magnetic field in a direction orthogonal to a fuse element to be formed between the paired electrodes through chaining of the solid particles.
摘要翻译： 非磁性材料的液体基体容纳在非磁性材料的绝缘容器内，并且一对电极设置在绝缘容器内，使得电极经由液体基质相互面对。 导电颗粒流体地分散在液体基质中。 在绝缘容器的外部设置有磁场产生部，以便通过固体颗粒的链接，在与成对电极之间形成的熔丝元件正交的方向上产生磁场。
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公开(公告)号：US20090146666A1
公开(公告)日：2009-06-11
申请号：US11997215
申请日：2006-10-13
申请人： Shinya Ohtsuka , Masayuki Hikita , Takashi Teshima , Yuji Hayashi
发明人： Shinya Ohtsuka , Masayuki Hikita , Takashi Teshima , Yuji Hayashi
CPC分类号： G01R31/1272 , G01R29/0871
摘要： The present invention comprises an antenna adapted to measure an electromagnetic wave radiated from a device to be measured stemming from partial discharge and having sensitivity at least in the UHF band; a filter for extracting a TEM mode component from a measured time waveform; and a measurement device body including a processing section adapted to obtain a second order integral value of the time waveform having undergone the filter processing and obtain a discharge charge quantity from the value. The present invention also comprises an electromagnetic wave radiation simulating apparatus for inputting a pseudo discharge signal to the device to be measured and previously obtaining the relation between the second order integral value and the discharge charge quantity, wherein the processing section obtains the discharge charge quantity from the second order integral value with reference to the previously obtained relation between the second order integral value and the discharge charge quantity.
摘要翻译： 本发明包括天线，其适于测量从部分放电引起的待测量器件辐射的电磁波，并且具有至少在UHF频带中的灵敏度; 用于从测量的时间波形中提取TEM模式分量的滤波器; 以及测量装置本体，其包括处理部，其适于获得经过过滤处理的时间波形的二阶积分值，并从该值获得放电电荷量。 本发明还包括：电磁波辐射模拟装置，用于向待测装置输入伪放电信号，并预先获得二次积分值与放电电荷量之间的关系，其中，处理部从 参考先前获得的二阶积分值与放电电荷量之间的关系的二阶积分值。
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公开(公告)号：US20100259354A1
公开(公告)日：2010-10-14
申请号：US12741464
申请日：2008-10-20
IPC分类号： H01H85/00
摘要： A liquid matrix of a nonmagnetic material is accommodated within an insulative container of a nonmagnetic material, and a pair of electrodes is disposed within the insulative container such that the electrodes face each other via the liquid matrix. Conductive particles are fluidly dispersed in the liquid matrix. A magnetic field generation section is provided externally of the insulative container so as to generate a magnetic field in a direction orthogonal to a fuse element to be formed between the paired electrodes through chaining of the solid particles.
摘要翻译： 非磁性材料的液体基体容纳在非磁性材料的绝缘容器内，并且一对电极设置在绝缘容器内，使得电极经由液体基质相互面对。 导电颗粒流体地分散在液体基质中。 在绝缘容器的外部设置有磁场产生部，以便通过固体颗粒的链接，在与成对电极之间形成的熔丝元件正交的方向上产生磁场。
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公开(公告)号：US07782063B2
公开(公告)日：2010-08-24
申请号：US11997215
申请日：2006-10-13
申请人： Shinya Ohtsuka , Masayuki Hikita , Takashi Teshima , Yuji Hayashi
发明人： Shinya Ohtsuka , Masayuki Hikita , Takashi Teshima , Yuji Hayashi
IPC分类号： G01R31/08
CPC分类号： G01R31/1272 , G01R29/0871
摘要： The present invention includes an antenna for measuring an electromagnetic wave radiated from a device to be measured stemming from partial discharge and having sensitivity at least in the UHF band; a filter for extracting a TEM mode component from a measured time waveform; and a measurement device body including a processing section adapted to obtain a second order integral value of the time waveform having undergone the filter processing and obtain a discharge charge quantity from the value. The present invention also comprises an electromagnetic wave radiation simulating apparatus for inputting a pseudo discharge signal to the device to be measured and previously obtaining the relation between the second order integral value and the discharge charge quantity, the processing section obtains the discharge charge quantity from the second order integral value with reference to the previously obtained relation between the second order integral value and the discharge charge quantity.
摘要翻译： 本发明包括一个天线，用于测量从部分放电产生的测量装置辐射的电磁波，并至少具有UHF频带的灵敏度; 用于从测量的时间波形中提取TEM模式分量的滤波器; 以及测量装置本体，其包括处理部，其适于获得经过过滤处理的时间波形的二阶积分值，并从该值获得放电电荷量。 本发明还包括电磁波辐射模拟装置，用于向待测装置输入伪放电信号，并预先获得二次积分值与放电电荷量之间的关系，处理部从第 参考先前获得的二阶积分值与放电电荷量之间的关系的二阶积分值。
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