公开(公告)号：US07560286B2

公开(公告)日：2009-07-14

申请号：US10095017

申请日：2002-03-12

申请人： Hideo Naoki ,  Terumi Nakajima ,  Yasufumi Ohfune ,  Tetsuro Shinada ,  Kazuya Murata

发明人： Hideo Naoki ,  Terumi Nakajima ,  Yasufumi Ohfune ,  Tetsuro Shinada ,  Kazuya Murata

IPC分类号： G01N24/00

CPC分类号： C07C49/753 ,  C07C45/70 ,  Y10T436/17 ,  Y10T436/24

摘要： A method for effectively causing charge-remote fragmentation (CRF) when the structural analysis of an nitrogen-containing organic compound is performed using a high-energy collisional-induced dissociation-mass/mass spectrum (CID-MS/MS spectrum), a reagent to be used in such a method, and a method for analyzing an organic compound by the induction of CRF are provided. The method for the induction of charge-remote fragmentation (CRF) using a high-energy collisional-induced dissociation-mass/mass spectrum (CID-MS/MS spectrum) has the step of: introducing a squaric acid residue into an end of a nitrogen-containing organic compound. The squaric acid residue is represented by a chemical formula (I): The reagent is provided for introducing such a squaric acid residue. Furthermore, the method is provided for analyzing such an organic compound by the induction of CRF.

摘要翻译： 当使用高能碰撞诱导的解离质谱/质谱（CID-MS / MS谱）进行含氮有机化合物的结构分析时，有效地引起电荷远程碎片化（CRF）的方法， 用于这种方法，并且提供了通过诱导CRF分析有机化合物的方法。 使用高能碰撞诱导的解离 - 质谱/质谱（CID-MS / MS谱）诱导电荷远程碎裂（CRF）的方法具有以下步骤：将方酸残渣引入到 含氮有机化合物。 方酸残基由化学式（I）表示：提供用于引入方酸残基的试剂。 此外，提供了通过诱导CRF分析这种有机化合物的方法。