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公开(公告)号：US3989682A
公开(公告)日：1976-11-02
申请号：US595834
申请日：1975-07-14
CPC分类号： C07H19/16
摘要： A process for preparing 2-thioadenosine, useful as an intermediate for the preparation of S-substituted-2-thioadenosines having a platelet aggregation inhibitory activity and a coronary vasodilating activity, which comprises reacting 5-amino-1-.beta.-D-ribofuranosylimidazole-4-carboxamide oxime or an O-substituted oxime thereof with carbon disulfide in a closed reaction zone at a temperature of from about 50.degree. to about 200.degree. C in a solvent.
摘要翻译： 一种制备2-硫代腺嘌呤的方法，其可用作制备具有血小板聚集抑制活性和冠状血管扩张活性的S-取代-2-硫代腺嘌呤的中间体，其包括使5-氨基-1-β-呋喃核糖咪唑 - 4-羧酰胺肟或其O-取代的肟与二硫化碳在封闭反应区中在约50℃至约200℃的温度下在溶剂中反应。
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公开(公告)号：US3968102A
公开(公告)日：1976-07-06
申请号：US568491
申请日：1975-04-16
IPC分类号： C07H19/16
CPC分类号： C07H19/16 , Y10S514/822 , Y10S514/929
摘要： S-Substituted-2-thioadenosines represented by the formula (I): ##SPC1##wherein R is as defined hereinafter, useful as a platelet aggregation inhibitor and a coronary vasodilator.
摘要翻译： 由式（I）表示的S-取代的2-硫代腺嘌呤：
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公开(公告)号：US4053466A
公开(公告)日：1977-10-11
申请号：US727484
申请日：1976-09-28
IPC分类号： C07D307/46 , C07D307/54 , C07D333/22 , C07D333/24 , C07D333/28 , C07D307/26 , C07D307/28 , C07D333/10 , C07D333/12
CPC分类号： C07D333/28 , C07D307/46 , C07D307/54 , C07D333/22 , C07D333/24
摘要： (E)-2-[p-(.beta.-Substituted-vinyl)phenyl]alkanoic acids represented by the formula (I): ##STR1## wherein R.sub.1 and X are as hereinafter defined, having anti-inflammatory, analgesic, antipyretic and platelet aggregation inhibitory activities.
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