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1.发明授权Infectious Japanese encephalitis virus cDNA clones that produce highly attenuated recombinant Japanese encephalitis virus, and vaccines thereof 失效产生高度减毒的重组日本脑炎病毒的感染性日本脑炎病毒cDNA克隆及其疫苗
公开(公告)号：US5736148A
公开(公告)日：1998-04-07
申请号：US438702
申请日：1995-05-11
CPC分类号： C07K14/005 , A61K39/00 , C12N2770/24122
摘要： cDNA clones containing the entire genome of Japanese encephalitis virus (JEV) were used to produce infectious, recombinant JEV particles with diverse virulence properties. Certain viruses retained the immunogenicity of JEV, but lacked the ability to cause encephalitis. The mutation associated with this loss of neurovirulence was localized to a nucleotide substitution in the codon encoding the 138th amino acid of the envelop protein, resulting in a mutation of an acidic amino acid to a basic amino acid. Attenuated viruses containing this mutation form the basis of a greatly improved, molecularly defined vaccine for the prevention of Japanese encephalitis in humans.
摘要翻译： 使用含有日本脑炎病毒（JEV）全部基因组的cDNA克隆产生具有不同毒力特性的感染性重组JEV颗粒。 某些病毒保留了JEV的免疫原性，但缺乏导致脑炎的能力。 与神经毒力丧失相关的突变被定位于编码包膜蛋白的第138位氨基酸的密码子中的核苷酸取代，导致酸性氨基酸向碱性氨基酸的突变。 含有这种突变的减毒病毒是预防人类日本脑炎的大大改进的分子定义疫苗的基础。
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公开(公告)号：US5742609A
公开(公告)日：1998-04-21
申请号：US389854
申请日：1995-02-17
摘要： The smart canister systems disclosed herein enables missile population to increase while minimizing the need for additional interface hardware. Particularly, multiplexing and demultiplexing functions and conversion flexibility enable the system to be adaptable to different types of missile characteristics and hardware. A redundant, bi-directional bus architecture with a distributed and dynamically reconfigurable control as well as enhanced built-in-test, fault monitoring and display capability enable the smart canister systems to provide a faster response time and higher launcher availability in a multifarious missile environment.
摘要翻译： 本文公开的智能罐系统使导弹群体增加，同时最小化对附加接口硬件的需要。 特别地，复用和解复用功能和转换灵活性使得系统能够适应不同类型的导弹特性和硬件。 具有分布式和动态可重配置控制以及增强的内置测试，故障监测和显示功能的冗余双向总线架构使智能卡系统能够在多种导弹环境中提供更快的响应时间和更高的发射器可用性 。
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