公开(公告)号：US20110190714A1

公开(公告)日：2011-08-04

申请号：US13122616

申请日：2009-12-04

申请人： Hideshi Oda ,  Hidetoshi Taima ,  Shuji Ishikawa ,  Yasuto Saita

发明人： Hideshi Oda ,  Hidetoshi Taima ,  Shuji Ishikawa ,  Yasuto Saita

IPC分类号： A61M37/00 ,  B23P11/00

CPC分类号： C09K5/16 ,  A61F7/03 ,  A61F7/034 ,  Y10T29/49826

摘要： A heat generating device includes a holder and a heat generating member that is enclosed in the holder and that contains an oxidizable metal, a reaction accelerator, an electrolyte, and water. The heat generating member contains a transdermally-absorbable medicament and a solvent for dissolving the transdermally-absorbable medicament. It is preferable that the solvent is at least one type of polyol selected from polyols that are in their liquid state at 25° C. It is also preferable that the heat generating member further contains at least one type of solvent composed of an oily agent that is in its liquid state at 25° C. It is also preferable that the heat generating member further contains a surfactant. It is also preferable that the polyol is polyethylene glycol.

摘要翻译： 发热装置包括保持器和封闭在保持器中并且包含可氧化金属，反应促进剂，电解质和水的发热元件。 发热构件含有经皮吸收药物和用于溶解透皮吸收药物的溶剂。 优选溶剂是选自在25℃下处于液态的多元醇中的至少一种类型的多元醇。还优选的是，发热体还含有至少一种由油性成分组成的溶剂， 在25℃下处于液态。还优选的是，发热体还含有表面活性剂。 还优选多元醇是聚乙二醇。

公开(公告)号：US08945072B2

公开(公告)日：2015-02-03

申请号：US13122616

申请日：2009-12-04

申请人： Hideshi Oda ,  Hidetoshi Taima ,  Shuji Ishikawa ,  Yasuto Saita

发明人： Hideshi Oda ,  Hidetoshi Taima ,  Shuji Ishikawa ,  Yasuto Saita

IPC分类号： A61M35/00 ,  C09K5/16 ,  A61F7/03

CPC分类号： C09K5/16 ,  A61F7/03 ,  A61F7/034 ,  Y10T29/49826

摘要： A heat generating device includes a holder and a heat generating member that is enclosed in the holder and that contains an oxidizable metal, a reaction accelerator, an electrolyte, and water. The heat generating member contains a transdermally-absorbable medicament and a solvent for dissolving the transdermally-absorbable medicament. It is preferable that the solvent is at least one type of polyol selected from polyols that are in their liquid state at 25° C. It is also preferable that the heat generating member further contains at least one type of solvent composed of an oily agent that is in its liquid state at 25° C. It is also preferable that the heat generating member further contains a surfactant. It is also preferable that the polyol is polyethylene glycol.

摘要翻译： 发热装置包括保持器和封闭在保持器中并且包含可氧化金属，反应促进剂，电解质和水的发热元件。 发热构件含有经皮吸收药物和用于溶解透皮吸收药物的溶剂。 优选溶剂是选自在25℃下处于液态的多元醇中的至少一种类型的多元醇。还优选的是，发热体还含有至少一种由油性成分组成的溶剂， 在25℃下处于液态。还优选的是，发热体还含有表面活性剂。 还优选多元醇是聚乙二醇。

公开(公告)号：US5756857A

公开(公告)日：1998-05-26

申请号：US433375

申请日：1995-04-25

申请人： Mitsuru Kuribayashi ,  Mitsuru Tanoue ,  Akira Nakagawa ,  Munehiko Hirano ,  Hideshi Oda

发明人： Mitsuru Kuribayashi ,  Mitsuru Tanoue ,  Akira Nakagawa ,  Munehiko Hirano ,  Hideshi Oda

IPC分类号： C07C43/13 ,  C07C43/188 ,  C07C43/196 ,  C07C41/00

CPC分类号： C07C43/13 ,  C07C43/188 ,  C07C43/196 ,  C07C2101/14

摘要： A cyclohexanol derivative represented by the following general formula (1) and preferably the following general formula (1a): ##STR1## wherein R represents a linear or branched alkyl group having 1 to 5 carbon atoms. The above cyclohexanol derivative imparts satisfactory refrigeration to not only the mouth mucosa but also the skin. Moreover, it is practically odorless. A cool feeling and various cool feeling compositions which are practically odorless can be obtained from the cyclohexanol derivative.

摘要翻译： PCT No.PCT / JP93 / 01562 Sec。 371日期：1995年4月28日 102（e）日期1995年4月28日PCT提交1993年10月28日PCT公布。 公开号WO94 / 10117 日期：1994年5月11日由以下通式（1）表示的环己醇衍生物，优选以下通式（1a）表示：（1a）其中R表示具有1〜 5个碳原子。 上述环己醇衍生物不仅对口腔粘膜而且对皮肤赋予令人满意的制冷。 此外，它几乎无臭。 可以从环己醇衍生物中获得几乎无臭的凉爽感和各种凉爽感觉组合物。

公开(公告)号：US06471984B1

公开(公告)日：2002-10-29

申请号：US09694477

申请日：2000-10-24

申请人： Nobuchika Hirashima ,  Hideshi Oda ,  Daisuke Miyata

发明人： Nobuchika Hirashima ,  Hideshi Oda ,  Daisuke Miyata

IPC分类号： A61F1300

CPC分类号： A61K9/7053 ,  A61K9/7061 ,  A61K9/7076 ,  A61K47/10 ,  C08K5/0016 ,  C08K5/06

摘要： A plasticizer consisting of 3-L-menthoxypropane-1,2-diol is excellent in plasticizing effect on a patch base and high in safety, stability and miscibility with the base. A patch containing the plasticizer is excellent in overall feeling such as adhesion and fit feeling to the skin and peeling pain.

摘要翻译： 由3-L-薄荷氧基丙烷-1,2-二醇组成的增塑剂对贴剂基具有优异的增塑效果，并且与基材的安全性，稳定性和混溶性高。 含有增塑剂的贴剂具有优异的整体感觉，例如对皮肤的粘合和贴合感以及剥离疼痛。

公开(公告)号：US5725874A

公开(公告)日：1998-03-10

申请号：US553615

申请日：1995-11-16

申请人： Hideshi Oda ,  Tetsuro Tateishi ,  Akira Nakagawa ,  Munehiko Hirano ,  Koki Shoho

发明人： Hideshi Oda ,  Tetsuro Tateishi ,  Akira Nakagawa ,  Munehiko Hirano ,  Koki Shoho

IPC分类号： A61K9/00 ,  A61K9/70 ,  A61K47/10 ,  A61F13/00

CPC分类号： A61K9/7053 ,  A61K47/10 ,  A61K9/0014 ,  A61K9/7061 ,  A61K9/7076 ,  Y10S514/937 ,  Y10S514/944 ,  Y10S514/945 ,  Y10S514/969

摘要： Percutaneously absorbable preparations which comprise, by weight, 0.001 to 20%, preferably 0.1 to 20%, of 3-l-menthoxy-propane-1,2-diol as a solubilizer for a drug and 0.001 to 20%, preferably 0.5 to 10%, of the drug as two essential ingredients, the balance being other ingredients as adjuvants selected from water-soluble polymers, monohydric alcohols, polyhydric alcohols, rosin esters, water, fatty acid esters, hydrocarbons, softening agents, emulsifying agents. The preparations are in the forms of poultice, plasters, ointments, gels, creams, gel-like creams, lotions, reserver patches, liniments, aerosols and may be used in packs.

摘要翻译： PCT No.PCT / JP94 / 00800 Sec。 371日期：1995年11月16日 102（e）1995年11月16日日期PCT 1994年5月18日PCT PCT。 公开号WO94 / 26309 日期1994年11月24日可皮吸收制剂，其含量为0.001〜20％，优选为0.1〜20％的作为药物增溶剂的3,1-甲氧基 - 丙烷-1,2-二醇，0.001〜20％ ，优选0.5〜10％的药物作为两种必需成分，余量为选自水溶性聚合物，一元醇，多元醇，松香酯，水，脂肪酸酯，烃，软化剂，​​乳化剂 代理商 制剂的形式包括泥敷剂，膏药，软膏剂，凝胶剂，霜剂，凝胶状乳膏剂，乳液剂，储备剂，搽剂，气雾剂，可用于包装。