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公开(公告)号:US5302701A
公开(公告)日:1994-04-12
申请号:US959369
申请日:1992-10-13
申请人: Hidetaka Hashi , Fusao Kimizuka , Ikunoshin Kato , Mika Hatai , Yoshihito Yaoi
发明人: Hidetaka Hashi , Fusao Kimizuka , Ikunoshin Kato , Mika Hatai , Yoshihito Yaoi
IPC分类号: A61K38/00 , A61P17/00 , A61P43/00 , C07K14/50 , C07K14/52 , C07K14/78 , C07K19/00 , C12N15/09 , C12P21/02 , C12R1/19 , A61K35/14 , C07K13/00
CPC分类号: C07K14/50 , C07K14/78 , A61K38/00 , C07K2319/00 , Y10S530/83
摘要: This present invention is directed to an artificial functional polypeptide represented by the following structural formula [I]:X--(Y)m--Z [I]wherein X represents a polypeptide having cell-adhesive activity like that of human FN, Y represents a spacer, Z represents a polypeptide having fibroblast growth promoting activity like that of FGF, and m is 1 or 0. This polypeptide is particularly useful for pharmaceutical purposes.
摘要翻译: 本发明涉及由以下结构式(I)表示的人造功能多肽:X-(Y)mZ(I)其中X表示具有类似于人FN的细胞粘附活性的多肽,Y表示间隔基, Z表示具有如FGF的成纤维细胞生长促进活性的多肽,m为1或0.该多肽特别适用于制药目的。