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10 条记录 (耗时 0.027 秒)

    Process for producing granules containing branched amino acids
    5.
    发明授权
    Process for producing granules containing branched amino acids 有权
    生产含有支链氨基酸的颗粒的方法

    公开(公告)号：US07138142B2

    公开(公告)日：2006-11-21

    申请号：US10897000

    申请日：2004-07-23

    申请人： Hidetoshi Sakai ,  Mitsuyasu Ida ,  Chisato Makino ,  Tomoaki Kawano ,  Akira Yabuki

    发明人： Hidetoshi Sakai ,  Mitsuyasu Ida ,  Chisato Makino ,  Tomoaki Kawano ,  Akira Yabuki

    IPC分类号： A61K9/14 ,  A61K9/50

    CPC分类号： A61K9/0095 ,  A61K9/1617 ,  A61K9/1635 ,  A61K31/198

    摘要： The problem of the present invention is to provide pharmaceutical granules containing, as active amino acid ingredients, three kinds of branched chain amino acids of isoleucine, leucine and valine, which has a smaller specific volume than conventional products, and a production method thereof. As a result of intensive studies, granules containing, as active amino acid ingredients, three kinds of branched chain amino acids of isoleucine, leucine and valine and a production method thereof have been provided, which are characterized by adding an acid to a particle mixture of three kinds of branched chain amino acids of isoleucine, leucine and valine and granulating the mixture, which has solved the above-mentioned problem.

    摘要翻译： 本发明的问题是提供含有作为活性氨基酸成分的异氰酸，亮氨酸，缬氨酸三种支链氨基酸的药物颗粒，其具有比常规产品更小的比容量及其制备方法。 作为深入研究的结果，提供了含有作为活性氨基酸成分的异亮氨酸，亮氨酸和缬氨酸的三种支链氨基酸的颗粒及其制备方法，其特征在于将酸添加到 3种异亮氨酸，亮氨酸，缬氨酸的支链氨基酸，混合造粒，解决了上述问题。

    Antidiabetic preparation for oral administration
    7.
    发明授权
    Antidiabetic preparation for oral administration 失效
    用于口服给药的抗糖尿病制剂

    公开(公告)号：US06830759B2

    公开(公告)日：2004-12-14

    申请号：US10183405

    申请日：2002-06-28

    申请人： Chisato Makino ,  Nobutaka Ninomiya ,  Haruo Orita ,  Hidetoshi Sakai ,  Akira Yabuki ,  Nobuo Kato ,  Shigeru Shioya

    发明人： Chisato Makino ,  Nobutaka Ninomiya ,  Haruo Orita ,  Hidetoshi Sakai ,  Akira Yabuki ,  Nobuo Kato ,  Shigeru Shioya

    IPC分类号： A61K920

    CPC分类号： A61K31/00 ,  A61K9/2077 ,  A61K9/2081 ,  A61K31/195 ,  A61K45/06

    摘要： There is provided a single preparation which directly decreases both of the post prandial blood glucose level and the fasting blood glucose level close to normal levels, by release-sustaining a drug capable of decreasing the post prandial blood glucose level of diabetic patients close to the normal level, or mixing a controlled release drug capable of decreasing the post prandial blood glucose level close to the normal level with an immediate release drug. It is particularly preferable that the drug capable of decreasing the post prandial blood glucose level close to the normal level is nateglinide, repaglinide, or mitiglinide (KAD-1229).

    摘要翻译： 提供了一种直接降低餐后血糖水平和接近正常水平的空腹血糖水平的单一制剂，通过释放维持能够降低接近正常的糖尿病患者的餐后血糖水平的药物 或者使用立即释放药物混合能够降低接近正常水平的餐后血糖水平的控释药物。 特别优选能够降低接近正常水平的餐后血糖水平的药物是那格列奈，瑞格列奈或米格列奈（KAD-1229）。

    Process for producing granules containing branched amino acids
    8.
    发明申请
    Process for producing granules containing branched amino acids 有权
    生产含有支链氨基酸的颗粒的方法

    公开(公告)号：US20050003015A1

    公开(公告)日：2005-01-06

    申请号：US10897000

    申请日：2004-07-23

    申请人： Hidetoshi Sakai ,  Mitsuyasu Ida ,  Chisato Makino ,  Tomoaki Kawano ,  Akira Yabuki

    发明人： Hidetoshi Sakai ,  Mitsuyasu Ida ,  Chisato Makino ,  Tomoaki Kawano ,  Akira Yabuki

    IPC分类号： A61J3/06 ,  A61K9/00 ,  A61K9/16 ,  A61K31/198 ,  A61K47/04 ,  A61K47/12 ,  A61P1/16 ,  A61K9/14

    CPC分类号： A61K9/0095 ,  A61K9/1617 ,  A61K9/1635 ,  A61K31/198

    摘要： The problem of the present invention is to provide pharmaceutical granules containing, as active amino acid ingredients, three kinds of branched chain amino acids of isoleucine, leucine and valine, which has a smaller specific volume than conventional products, and a production method thereof. As a result of intensive studies, granules containing, as active amino acid ingredients, three kinds of branched chain amino acids of isoleucine, leucine and valine and a production method thereof have been provided, which are characterized by adding an acid to a particle mixture of three kinds of branched chain amino acids of isoleucine, leucine and valine and granulating the mixture, which has solved the above-mentioned problem.

    摘要翻译： 本发明的问题是提供含有作为活性氨基酸成分的异氰酸，亮氨酸，缬氨酸三种支链氨基酸的药物颗粒，其具有比常规产品更小的比容量及其制备方法。 作为深入研究的结果，提供了含有作为活性氨基酸成分的异亮氨酸，亮氨酸和缬氨酸的三种支链氨基酸的颗粒及其制备方法，其特征在于将酸添加到 3种异亮氨酸，亮氨酸，缬氨酸的支链氨基酸，混合造粒，解决了上述问题。