公开(公告)号：US07666836B2

公开(公告)日：2010-02-23

申请号：US11311363

申请日：2005-12-20

申请人： Hilde Riethmuller-Winzen ,  Jurgen Engel ,  Ricardo Felberbaum ,  Klaus Diedrich ,  Kupker Wolfgang

发明人： Hilde Riethmuller-Winzen ,  Jurgen Engel ,  Ricardo Felberbaum ,  Klaus Diedrich ,  Kupker Wolfgang

IPC分类号： A61K38/00 ,  A61K31/497 ,  A61K31/519 ,  A61K31/505

CPC分类号： A61K38/08 ,  A61K45/06 ,  A61K2300/00

摘要： The present inventions provides a method for therapeutic management of extrauterine proliferation of endometrial tissue, chronic pelvic pain and fallopian tube obstruction by short term induction treatment with an LH-RH antagonist for 4 to 12 weeks. According to another aspect of the present invention, the short term LH-RH treatment is followed by the combined or separate administration of one or more active agents selected from the group consisting of a contraceptive, preferably an oral contraceptive, a non-steroidal anti-rheumatic agent, an analgetic, an androgen other than a 17-alpha-alkyl substituted testosterone or any combinations thereof. According to a further aspect of the present invention a pharmaceutical composition comprising an LHRH antagonist and one ore more active agents selected from the group consisting of a contraceptive, preferably an oral contraceptive, a non-steroidal anti-rheumatic agent, an analgetic, an androgen other than a 17-alpha-alkyl substituted testosterone or any combinations thereof are provided.

摘要翻译： 本发明提供了一种通过LH-RH拮抗剂短期诱导治疗4至12周来治疗子宫内膜组织宫外增生，慢性盆腔疼痛和输卵管阻塞的方法。 根据本发明的另一方面，短期LH-RH治疗之后是联合或分开施用一种或多种活性剂，所述活性剂选自避孕药，优选口服避孕药，非类固醇抗生素， 风湿药，止痛剂，除17-α-烷基取代的睾酮以外的雄激素或其任何组合。 根据本发明的另一方面，包含LHRH拮抗剂和一种或多种选自避孕药，优选口服避孕药，非甾体抗风湿药，止痛剂，雄激素的活性剂的药物组合物 提供除17-α-烷基取代的睾酮或其任何组合以外的物质。

公开(公告)号：US20080255053A1

公开(公告)日：2008-10-16

申请号：US12099091

申请日：2008-04-07

申请人： Hilde RIETHMULLER-WINZEN ,  Jurgen Engel ,  Ricardo Felberbaum ,  Klaus Diedrich ,  Kupker Wolfgang

发明人： Hilde RIETHMULLER-WINZEN ,  Jurgen Engel ,  Ricardo Felberbaum ,  Klaus Diedrich ,  Kupker Wolfgang

IPC分类号： A61K38/08

CPC分类号： A61K38/08 ,  A61K45/06 ,  A61K2300/00

摘要： The present inventions provides a method for therapeutic management of extrauterine proliferation of endometrial tissue, chronic pelvic pain and fallopian tube obstruction by short term induction treatment with an LH-RH antagonist for 4 to 12 weeks. According to another aspect of the present invention, the short term LH-RH treatment is followed by the combined or separate administration of one or more active agents selected from the group consisting of a contraceptive, preferably an oral contraceptive, a non-steroidal anti-rheumatic agent, an analgetic, an androgen other than a 17-alpha-alkyl substituted testosterone or any combinations thereof. According to a further aspect of the present invention a pharmaceutical composition comprising an LHRH antagonist and one ore more active agents selected from the group consisting of a contraceptive, preferably an oral contraceptive, a non-steroidal anti-rheumatic agent, an analgetic, an androgen other than a 17-alpha-alkyl substituted testosterone or any combinations thereof are provided.

摘要翻译： 本发明提供了一种通过LH-RH拮抗剂短期诱导治疗4至12周来治疗子宫内膜组织宫外增生，慢性盆腔疼痛和输卵管阻塞的方法。 根据本发明的另一方面，短期LH-RH治疗之后是联合或分开施用一种或多种活性剂，所述活性剂选自避孕药，优选口服避孕药，非类固醇抗生素， 风湿药，止痛剂，除17-α-烷基取代的睾酮以外的雄激素或其任何组合。 根据本发明的另一方面，包含LHRH拮抗剂和一种或多种选自避孕药，优选口服避孕药，非甾体抗风湿药，止痛剂，雄激素的活性剂的药物组合物 提供除17-α-烷基取代的睾酮或其任何组合以外的物质。