摘要:
Provided is a novel useful microRNA having improved anti-tumor activity, obtained by introducing a variation in a microRNA which is present in-vivo and which exhibits an anti-tumor effect. This microRNA containing a base sequence (SEQ ID NO: 1) obtained by varying a predetermined region of the base sequence of miR-29b is able to exhibit a particularly outstanding anti-tumor effect.
摘要:
An object of the present invention is to provide an agent that potentiates the antitumor effect of an anticancer agent by allowing efficient accumulation of the anticancer agent in tumor tissue. The administration of carbonate apatite with the anticancer agent allows efficient accumulation of the anticancer agent in the tumor tissue to dramatically potentiate the antitumor effect of the anticancer agent.
摘要:
In one embodiment, a unified pointer message 300 may describe in a single type of pointer message a coordinate input from a user via multiple types of pointer devices. An input device interface 150 may receive a coordinate input 350 from an input device. A processor 120 may execute an application programming interface layer 430 that creates a unified pointer message 300 for the coordinate input 350. The processor 120 may send the unified pointer message 300 to an application. The processor 120 may process a device specific data set 244 unhandled by the application.
摘要:
A polyester monofilament package is formed by reeling a polyester monofilament comprising polyethylene terephthalate and satisfies all of the following requirements (a) to (d): (a) the coefficient of dynamic friction between yarns of the polyester monofilament being 0.13 μd or less; (b) the package end being in a tapered shape with a taper angle (0) of 75° or less; (c) the variation gradient in unreeling tension (AT) being 0.02 cN/dtex-m or less; and (d) in a part of a reeling thickness of 1 mm in the inner layer of the package, the variation in contraction stress of the polyester monofilament being 3.0 cN/dtex or less.
摘要:
The subject disclosure relates to managing z-dimensional ordering of elements within a computing system display through the use of z-order bands. As described herein, z-order bands are utilized to arrange windows and other graphics corresponding to respective application types. A policy engine controls which windows and/or other graphical elements can enter and exit each band. Graphical elements within a given band can additionally be subject to per-band properties corresponding to the band and/or user preferences. As additionally described herein, z-order bands and/or other suitable mechanisms are utilized to facilitate registration watermarking for a computing environment by rendering a registration watermark display upon determining that one or more licensed elements of a computing system have not been registered. The registration watermark display is assigned a z-order band that enables its display over all other graphical elements associated with the computing system and prevents other graphical elements from interfering with its display.
摘要:
In aspects, interactions between processes of a desktop are allowed or denied based on security data. The security data may comprise a first bitmap that indicates whether a requesting process is allowed to cause an action to occur, a second bitmap that indicates whether a process is protected from having an action occur, and a third bitmap that indicates whether the requesting process may override protection, if any, in causing the action to occur.
摘要:
A compound of the formula: wherein R1 is amino or protected amino; R2 is hydrogen, lower alkyl or hydroxy protective group; R3 is carboxy or protected carboxy; R4 is an unsubstituted 5, 6 or 7-membered heteromonocyclic group containing two nitrogen atoms as heteroatoms, and which optionally further contains one oxygen or sulfur atom; or R4 is said 5, 6 or 7-membered heteromonocyclic group substituted by 1 to 4 groups selected from the group consisting of lower alkyl, lower alkoxy, lower alkylthio, lower alkylamino, cyclo(lower)alkyl, cyclo(lower)alkenyl, halogen, amino, protected amino, protected hydroxy, cyano, nitro, carboxy, hydroxy(lower)alkyl, amino(lower)alkyl, and carbamoyloxy; and n is 1 or 2.
摘要翻译:下式的化合物:其中R 1是氨基或被保护的氨基; R 2是氢,低级烷基或羟基保护基; R 3是羧基或被保护的羧基; R 4是未取代的5,6或7元杂单环基, 杂原子,并且任选地还含有一个氧或硫原子; 或R4是由1-4个选自低级烷基,低级烷氧基,低级烷硫基,低级烷基氨基,环(低级)烷基,环(低级)烯基,卤素 ,氨基,保护的氨基,保护的羟基,氰基,硝基,羧基,羟基(低级)烷基,氨基(低级)烷基和氨基甲酰氧基; andn是1或2。
摘要:
A coating apparatus has compact coating assembly modules which require less storage space and are easier to handle and which through the common use of parts and accessory tools provide a reduced manufacturing cost of the apparatus as a whole. A coating assembly which rotates during coating and a coating assembly which does not rotate during coating can be interchangeably installed to a support frame. Two bearing cases are mounted on the support frame, and the coating assemblies each have two shaft parts which can be removably set in the bearing cases. The shaft parts of the rotating coating assembly can be rotatably set in the bearing cases, and a shaft part of the non-rotating coating assembly can, when set in its corresponding bearing case, be anchored to a fixed part so that it cannot rotate. Another coating assembly which does not rotate during coating has left and right mounting parts which can be removably fixed to bearing cradle parts of the bearing cases.
摘要:
A compound of the formula: ##STR1## wherein R.sup.1 is amino, R.sup.2 is hydrogen,R.sup.3 is carboxy,R.sup.4 is heterocyclic(lower)alkylthio wherein said heterocyclic group is pyrazolyl and said lower alkyl group is methyl, andR.sup.5 is halogen; and pharmaceutically acceptable salts thereof.