公开(公告)号：US08389538B2

公开(公告)日：2013-03-05

申请号：US12528787

申请日：2008-02-26

申请人： Hiroki Kakuta ,  Kenji Sasaki ,  Kayo Takamatsu ,  Atsushi Takano ,  Nobumasa Yakushiji ,  Kazunori Morohashi ,  Kenichi Morishita

发明人： Hiroki Kakuta ,  Kenji Sasaki ,  Kayo Takamatsu ,  Atsushi Takano ,  Nobumasa Yakushiji ,  Kazunori Morohashi ,  Kenichi Morishita

IPC分类号： A01N43/40 ,  A61K31/435 ,  C07D239/00

CPC分类号： C07D213/74 ,  A61K31/4409 ,  A61K31/444 ,  A61K31/505 ,  A61K31/506 ,  A61K45/06 ,  C07D213/80 ,  C07D213/82 ,  C07D239/42 ,  C07D401/12 ,  A61K2300/00

摘要： Disclosed is a compound represented by the general formula shown below, which can bind to a retinoid X receptor (RXR), which is one of nuclear receptors, and exhibit an agonistic or antagonistic action. [Wherein, R1 is selected from the group consisting of an alkyl group, an alkenyl group, an alkynyl group and an aryl group. R2 is selected from the group consisting of an alkoxy group, an alkyl group, an alkenyl group, an alkynyl group and an aryl group. W is NR3 or CR3; and R3 is selected from a hydrogen, an alkyl group, an alkenyl group, an alkynyl group and an aryl group. X1 and Y1 are selected from CH or N. X2 and Y2 are selected from CH, CR4 or N. R4 is selected from an alkyl group, an alkenyl group, an alkynyl group, an alkoxy group, a halogen, a nitro group and an amino group. Z is selected from a carboxylic acid, a carboxylate ester or a hydroxamic acid, which is bound directly or via an alkyl group, an alkenyl group or an alkynyl group.]

摘要翻译： 公开了由以下通式表示的化合物，其可以结合作为核受体之一的类视黄醇X受体（RXR），并表现出激动作用或拮抗作用。 [其中，R 1选自烷基，烯基，炔基和芳基。 R2选自烷氧基，烷基，烯基，炔基和芳基。 W是NR 3或CR 3; 并且R 3选自氢，烷基，烯基，炔基和芳基。 X 1和Y 1选自CH或N.X 2和Y 2选自CH，CR 4或N.R 4选自烷基，烯基，炔基，烷氧基，卤素，硝基和 氨基。 Z选自直接或通过烷基，烯基或炔基结合的羧酸，羧酸酯或异羟肟酸。]

公开(公告)号：US20100120742A1

公开(公告)日：2010-05-13

申请号：US12528787

申请日：2008-02-26

申请人： Hiroki Kakuta ,  Kenji Sasaki ,  Kayo Takamatsu ,  Atsushi Takano ,  Nobumasa Yakushji ,  Kazunore Morohashi ,  Kenichi Morishita

发明人： Hiroki Kakuta ,  Kenji Sasaki ,  Kayo Takamatsu ,  Atsushi Takano ,  Nobumasa Yakushji ,  Kazunore Morohashi ,  Kenichi Morishita

IPC分类号： A61K31/554 ,  C07C63/00 ,  A61K31/19 ,  C07D239/02 ,  A61K31/505 ,  C07D267/12

CPC分类号： C07D213/74 ,  A61K31/4409 ,  A61K31/444 ,  A61K31/505 ,  A61K31/506 ,  A61K45/06 ,  C07D213/80 ,  C07D213/82 ,  C07D239/42 ,  C07D401/12 ,  A61K2300/00

摘要： Disclosed is a compound represented by the general formula shown below, which can bind to a retinoid X receptor (RXR), which is one of nuclear receptors, and exhibit an agonistic or antagonistic action. [Wherein, R1 is selected from the group consisting of an alkyl group, an alkenyl group, an alkynyl group and an aryl group. R2 is selected from the group consisting of an alkoxy group, an alkyl group, an alkenyl group, an alkynyl group and an aryl group. W is NR3 or CR3; and R3 is selected from a hydrogen, an alkyl group, an alkenyl group, an alkynyl group and an aryl group. X1 and Y1 are selected from CH or N. X2 and Y2 are selected from CH, CR4 or N. R4 is selected from an alkyl group, an alkenyl group, an alkynyl group, an alkoxy group, a halogen, a nitro group and an amino group. Z is selected from a carboxylic acid, a carboxylate ester or a hydroxamic acid, which is bound directly or via an alkyl group, an alkenyl group or an alkynyl group.]

摘要翻译： 公开了由以下通式表示的化合物，其可以结合作为核受体之一的类视黄醇X受体（RXR），并表现出激动作用或拮抗作用。 [其中，R 1选自烷基，烯基，炔基和芳基。 R2选自烷氧基，烷基，烯基，炔基和芳基。 W是NR 3或CR 3; 并且R 3选自氢，烷基，烯基，炔基和芳基。 X 1和Y 1选自CH或N.X 2和Y 2选自CH，CR 4或N.R 4选自烷基，烯基，炔基，烷氧基，卤素，硝基和 氨基。 Z选自直接或通过烷基，烯基或炔基结合的羧酸，羧酸酯或异羟肟酸。]