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    Extract from plant of japanese parsley family and process for producing the same
    2.
    发明申请
    Extract from plant of japanese parsley family and process for producing the same 审中-公开
    从日本欧芹系列植物提取物及其生产方法

    公开(公告)号：US20070092587A1

    公开(公告)日：2007-04-26

    申请号：US10561431

    申请日：2004-06-18

    申请人： Hiromu Ohnogi ,  Katsumi Sugiyama ,  Nobuko Muraki ,  Tatsuji Enoki ,  Hiroaki Sagawa ,  Ikunoshin Kato

    发明人： Hiromu Ohnogi ,  Katsumi Sugiyama ,  Nobuko Muraki ,  Tatsuji Enoki ,  Hiroaki Sagawa ,  Ikunoshin Kato

    IPC分类号： A61K36/232

    CPC分类号： A61K36/232 ,  A23L2/02 ,  A23V2002/00 ,  A23V2250/21 ,  A23V2200/328

    摘要： The present invention provides an extract obtainable by extracting a plant belonging to Umbelliferae, or a processed product thereof, with a water-containing alcohol; a process for preparing the extract; a therapeutic agent or prophylactic agent for a disease accompanying an abnormality in an amount of insulin or insulin response and/or diabetic complications, characterized in that the therapeutic agent or prophylactic agent comprises as an effective ingredient the extract as defined above; an agent for an insulin-mimetic action, characterized in that the agent comprises as an effective ingredient the extract as defined above; a food, beverage or feed, comprising the extract as defined above; an agent for enhancing glucose uptake into a cell, characterized in that the agent comprises as an effective ingredient the extract as defined above; to an agent for inducing differentiation into an adipocyte, characterized in that the agent comprises as an effective ingredient the extract as defined above; and an inhibitory agent for aldose reductase, characterized in that the agent comprises as an effective ingredient the extract as define above.

    摘要翻译： 本发明提供通过用含水醇提取属于伞形赤霉属的植物或其加工产物而获得的提取物; 一种制备提取物的方法; 用于伴随胰岛素或胰岛素反应量和/或糖尿病并发症的异常的疾病的治疗剂或预防剂，其特征在于所述治疗剂或预防剂包含作为有效成分的上述提取物; 用于胰岛素模拟作用的药剂，其特征在于所述药剂包含如上所定义的提取物作为有效成分; 包含上述提取物的食品，饮料或饲料; 用于增强葡萄糖摄入细胞的药剂，其特征在于所述药剂包含如上所定义的提取物作为有效成分; 涉及诱导分化为脂肪细胞的药剂，其特征在于所述药剂包含如上所定义的提取物作为有效成分; 以及醛糖还原酶抑制剂，其特征在于，所述药剂含有作为有效成分的上述定义的提取物。

    Chalcone compound
    4.
    发明授权
    Chalcone compound 失效
    查耳酮化合物

    公开(公告)号：US07361774B2

    公开(公告)日：2008-04-22

    申请号：US10529859

    申请日：2003-09-29

    申请人： Hiromu Ohnogi ,  Katsumi Sugiyama ,  Nobuko Muraki ,  Tatsuji Enoki ,  Hiroaki Sagawa ,  Ikunoshin Kato

    发明人： Hiromu Ohnogi ,  Katsumi Sugiyama ,  Nobuko Muraki ,  Tatsuji Enoki ,  Hiroaki Sagawa ,  Ikunoshin Kato

    IPC分类号： C07D311/82 ,  C07D311/00 ,  A01N43/16

    CPC分类号： C07D311/80 ,  A23K20/121 ,  A23L33/10 ,  C07D311/58

    摘要： The present invention relates to a chalcone compound represented by the following general formula: wherein R1 and R2 are taken together with the carbon atom to which they are bound, respectively, to form a hydroxydimethyl hexane ring, or where R1 is a hydroxyl group, R2 is an isohexenyl group, a derivative thereof, or a salt thereof. Also, the present invention relates to a therapeutic agent or prophylactic agent for a disease requiring neuronal protection, suppression for nitrogen monoxide (NO) production, inhibition for aldose reductase or suppression for interleukin production, and a food, beverage or feed for treatment or prevention of the above-mentioned disease, characterized in that each comprises the above-mentioned compound as an effective ingredient.

    摘要翻译： 本发明涉及由下列通式表示的查尔酮化合物：其中R 1和R 2分别与它们所连接的碳原子一起取代， 形成羟基二甲基己烷环，或其中R 1是羟基，R 2是异己烯基，其衍生物或其盐。 此外，本发明涉及需要神经元保护，抑制一氧化氮（NO）产生，抑制醛糖还原酶或抑制白介素产生的疾病的治疗剂或预防剂，以及用于治疗或预防的食品，饮料或饲料 的上述疾病，其特征在于，每种都包含上述化合物作为有效成分。

    Remedy
    7.
    发明申请
    Remedy 审中-公开
    补救

    公开(公告)号：US20060051316A1

    公开(公告)日：2006-03-09

    申请号：US10537333

    申请日：2003-12-05

    申请人： Hiromu Ohnogi ,  Katsumi Sugiyama ,  Hiroaki Sagawa ,  Ikunoshin Kato

    发明人： Hiromu Ohnogi ,  Katsumi Sugiyama ,  Hiroaki Sagawa ,  Ikunoshin Kato

    IPC分类号： A61K31/74 ,  A61K31/737 ,  A61K31/727 ,  A61K31/715

    CPC分类号： A61K36/02 ,  A23L33/10 ,  A61K31/216 ,  A61K31/737 ,  A61K31/78

    摘要： The present invention relates to a therapeutic agent or prophylactic agent for a disease requiring enhancement of bone morphogenetic protein production or promotion of osteogenesis; an agent for enhancement of bone morphogenetic protein production or an agent for promotion of osteogenesis, a food, beverage or feed for enhancement of bone mornhogenetic protein production or promotion of osteogenesis, characterized in that each comprises as an effective ingredient at least one compound selected from the group consisting of (a) an acidic saccharide, (b) a polyacrylic acid, (c) chlorogenic acid and (d) an oxidation processed product of chlorogenic acid, or an extract derived from algae.

    摘要翻译： 本发明涉及需要增强骨形态发生蛋白产生或促进成骨的疾病的治疗剂或预防剂; 用于增强骨形态发生蛋白质产生的药物或用于促进成骨的药剂，用于增强骨发生蛋白质产生或促进成骨的食品，饮料或饲料，其特征在于，每种药物包含作为有效成分的至少一种选自 由（a）酸性糖，（b）聚丙烯酸，（c）绿原酸和（d）绿原酸的氧化加工产物或源自藻类的提取物组成的组。

    Remedy
    8.
    发明申请
    Remedy 审中-公开
    补救

    公开(公告)号：US20060034949A1

    公开(公告)日：2006-02-16

    申请号：US10524015

    申请日：2003-08-06

    申请人： Tatsuji Enoki ,  Kinuko Ogawa ,  Hiromu Ohnogi ,  Katsumi Sugiyama ,  Nobuko Muraki ,  Hiroaki Sagawa ,  Ikunoshin Kato

    发明人： Tatsuji Enoki ,  Kinuko Ogawa ,  Hiromu Ohnogi ,  Katsumi Sugiyama ,  Nobuko Muraki ,  Hiroaki Sagawa ,  Ikunoshin Kato

    IPC分类号： A61K36/232

    CPC分类号： A61K36/232 ,  A23L2/52 ,  A23L33/105 ,  A23V2002/00 ,  A23V2200/328 ,  A23V2250/21

    摘要： The present invention relates to a therapeutic agent or prophylactic agent for a disease accompanying an abnormality in an amount of insulin or insulin response, an insulin-mimetic action agent, a food, beverage, or feed for treating or preventing a disease accompanying an abnormality in an amount of insulin or insulin response, an agent for enhancement of glucose uptake into a cell, and an agent for induction of an adipocyte differentiation, each comprising as an effective ingredient a processed product derived from a plant belonging to Umbelliferae.

    摘要翻译： 本发明涉及一种伴随胰岛素或胰岛素反应量异常的疾病的治疗剂或预防剂，用于治疗或预防伴随异常的疾病的胰岛素模拟作用剂，食品，饮料或饲料 一定量的胰岛素或胰岛素反应，用于增强葡萄糖摄入细胞的药剂和用于诱导脂肪细胞分化的药剂，其各自包含衍生自属于伞形属植物的植物的加工产品作为有效成分。

    Food beverage or feed for the promotion of osteogenesis comprising umbelliferae, liliaceae or compositae plant species
    9.
    发明申请
    Food beverage or feed for the promotion of osteogenesis comprising umbelliferae, liliaceae or compositae plant species 审中-公开
    用于促进成骨的食物饮料或饲料，包括伞形花序，百合科或合成植物物种

    公开(公告)号：US20080008773A1

    公开(公告)日：2008-01-10

    申请号：US11819441

    申请日：2007-06-27

    申请人： Hiromu Ohnogi ,  Katsumi Sugiyama ,  Nobuko Muraki ,  Hiroaki Sagawa ,  Ikunoshin Kato

    发明人： Hiromu Ohnogi ,  Katsumi Sugiyama ,  Nobuko Muraki ,  Hiroaki Sagawa ,  Ikunoshin Kato

    IPC分类号： A61K36/886 ,  A61K36/00 ,  A61P19/00 ,  A61K36/28

    CPC分类号： C07D311/80 ,  A23K20/121 ,  A23L33/105 ,  A23V2002/00 ,  A61K31/353 ,  A61K36/23 ,  A61K36/232 ,  A61K36/282 ,  A61K36/8967 ,  A23V2200/306 ,  A23V2250/21

    摘要： The present invention relates to a therapeutic agent or prophylactic agent for a disease requiring promotion of osteogenesis or enhancement of bone morphogenetic protein production, an agent for promotion of osteogenesis or an agent for enhancement of bone morphogenetic protein production, and a food, beverage or feed for promotion of osteogenesis or enhancement of bone morphogenetic protein production, characterized in that each comprises as an effective ingredient a processed product derived from a plant. Also, the present invention relates to a method for measuring an enhancing action for bone morphogenetic protein production, a method for screening a substance having an enhancing action for bone morphogenetic protein production, and a method for preparing a substance having an enhancing action for bone morphogenetic protein production, each method using a specified cell.

    摘要翻译： 本发明涉及需要促进骨形成发生或增强骨形态发生蛋白质生成的疾病的治疗剂或预防剂，促进成骨的药剂或增强骨形态发生蛋白质生产的药剂，以及食品，饮料或饲料 用于促进成骨或增强骨形态发生蛋白质的生成，其特征在于，每种都包含作为有效成分的来自植物的加工产品。 另外，本发明涉及骨形态发生蛋白质生成增强作用的测定方法，骨形态发生蛋白质生成增强作用物质的筛选方法以及骨形态发生增强作用物质的制备方法 蛋白质生产，每种方法使用指定的细胞。

    Remedies
    10.
    发明申请
    Remedies 审中-公开
    补救措施

    公开(公告)号：US20060039998A1

    公开(公告)日：2006-02-23

    申请号：US10529860

    申请日：2003-09-29

    申请人： Hiromu Ohnogi ,  Katsumi Sugiyama ,  Nobuko Muraki ,  Hiroaki Sagawa ,  Ikunoshin Kato

    发明人： Hiromu Ohnogi ,  Katsumi Sugiyama ,  Nobuko Muraki ,  Hiroaki Sagawa ,  Ikunoshin Kato

    IPC分类号： A61K36/282 ,  A61K36/232 ,  A61K36/896 ,  A61K36/886

    CPC分类号： C07D311/80 ,  A23K20/121 ,  A23L33/105 ,  A23V2002/00 ,  A61K31/353 ,  A61K36/23 ,  A61K36/232 ,  A61K36/282 ,  A61K36/8967 ,  A23V2200/306 ,  A23V2250/21

    摘要： The present invention relates to a therapeutic agent or prophylactic agent for a disease requiring promotion of osteogenesis or enhancement of bone morphogenetic protein production, an agent for promotion of osteogenesis or an agent for enhancement of bone morphogenetic protein production, and a food, beverage or feed for promotion of osteogenesis or enhancement of bone morphogenetic protein production, characterized in that each comprises as an effective ingredient a processed product derived from a plant. Also, the present invention relates to a method for measuring an enhancing action for bone morphogenetic protein production, a method for screening a substance having an enhancing action for bone morphogenetic protein production, and a method for preparing a substance having an enhancing action for bone morphogenetic protein production, each method using a specified cell.

    摘要翻译： 本发明涉及需要促进骨形成发生或增强骨形态发生蛋白质生成的疾病的治疗剂或预防剂，促进成骨的药剂或增强骨形态发生蛋白质生产的药剂，以及食品，饮料或饲料 用于促进成骨或增强骨形态发生蛋白质的生成，其特征在于，每种都包含作为有效成分的来自植物的加工产品。 另外，本发明涉及骨形态发生蛋白质生成增强作用的测定方法，骨形态发生蛋白质生成增强作用物质的筛选方法以及骨形态发生增强作用物质的制备方法 蛋白质生产，每种方法使用指定的细胞。