公开(公告)号：US20090076136A1

公开(公告)日：2009-03-19

申请号：US12263809

申请日：2008-11-03

申请人： Tatsuji ENOKI ,  Eiji Kobayashi ,  Kinuko Ogawa ,  Yoko Kudo ,  Masashige Tanabe ,  Hiromu Ohnogi ,  Hiroaki Sagawa ,  Ikunoshin Kato

发明人： Tatsuji ENOKI ,  Eiji Kobayashi ,  Kinuko Ogawa ,  Yoko Kudo ,  Masashige Tanabe ,  Hiromu Ohnogi ,  Hiroaki Sagawa ,  Ikunoshin Kato

IPC分类号： A61K31/343 ,  A61K31/225 ,  A61K31/19 ,  A61K31/192 ,  A61K31/11 ,  A61P3/04 ,  A61P3/10

CPC分类号： A61K31/11 ,  A23K20/00 ,  A23L33/10

摘要： The present invention relates to a therapeutic agent or prophylactic agent for a disease accompanying an abnormality in an amount of insulin or insulin response, an insulin-mimetic action agent, a food, beverage, or feed, an agent for enhancement of glucose uptake into a cell, and an agent for inducing differentiation into an adipocyte, each comprising as an effective ingredient at least one compound selected from the group consisting of specified compounds having an insulin-mimetic action, derivatives thereof, and pharmacologically acceptable salts thereof.

摘要翻译： 本发明涉及一种伴随胰岛素或胰岛素反应量异常的疾病的治疗剂或预防剂，胰岛素模拟作用剂，食物，饮料或饲料，用于增强葡萄糖摄入 细胞和用于诱导分化成脂肪细胞的药剂，其各自包含至少一种选自具有胰岛素模拟作用的特定化合物，其衍生物和其药理学上可接受的盐的至少一种化合物作为有效成分。

公开(公告)号：US20060216362A1

公开(公告)日：2006-09-28

申请号：US10557184

申请日：2004-05-14

申请人： Tatsuji Enoki ,  Kinuko Ogawa ,  Hiromu Ohnogi ,  Nobuko Muraki ,  Yoko Kudo ,  Hiroaki Sagawa ,  Ikunoshin Kato

发明人： Tatsuji Enoki ,  Kinuko Ogawa ,  Hiromu Ohnogi ,  Nobuko Muraki ,  Yoko Kudo ,  Hiroaki Sagawa ,  Ikunoshin Kato

IPC分类号： A61K36/9066 ,  A61K36/886 ,  A61K36/282 ,  A61K36/28 ,  A61K36/704 ,  A61K36/185

CPC分类号： A61K36/896 ,  A23K20/10 ,  A23L33/105 ,  A61K36/185 ,  A61K36/28 ,  A61K36/282 ,  A61K36/287 ,  A61K36/70 ,  A61K36/704 ,  A61K36/886 ,  A61K36/906 ,  A61K36/9066

摘要： The present invention relates to a therapeutic agent and prophylactic agent for a disease accompanying an abnormality in an amount of insulin or insulin response, an agent for an insulin-mimetic action, a food, beverage and feed for treating a preventing a disease accompanying an abnormality in an amount of insulin or insulin response, an agent for enhancing glucose uptake into a cell, and an agent for inducing differentiation into an adipocyte, characterized in that each comprises as an effective ingredient a processed product derived from at least one plant selected from the group consisting of (a) a plant belonging to Tiliaceae, (b) a plant belonging to Zingiberaceae, (c) a plant belonging to Compositae, (d) a plant belonging to Liliaceae, and (e) a plant belonging to Polygonaceae.

摘要翻译： 本发明涉及一种伴随胰岛素或胰岛素反应量异常的疾病的治疗剂和预防剂，用于胰岛素模拟作用的药物，用于治疗预防伴随异常的疾病的食品，饮料和饲料 一定量的胰岛素或胰岛素反应，用于增强葡萄糖摄入细胞的药剂和用于诱导分化成脂肪细胞的药剂，其特征在于每种药物包含作为有效成分的来自至少一种选自以下的植物的加工产品： （a）属于尖嘴科的植物，（b）属于姜科的植物，（c）属于菊科的植物，（d）属于百合科的植物，和（e）属于Poly科的植物。

公开(公告)号：US20070092551A1

公开(公告)日：2007-04-26

申请号：US10555017

申请日：2004-04-30

申请人： Tatsuji Enoki ,  Eiji Kobayashi ,  Kinuko Ogawa ,  Yoko Kudo ,  Masashige Tanabe ,  Hiromu Ohnogi ,  Hiroaki Sagawa ,  Ikunoshin Kato

发明人： Tatsuji Enoki ,  Eiji Kobayashi ,  Kinuko Ogawa ,  Yoko Kudo ,  Masashige Tanabe ,  Hiromu Ohnogi ,  Hiroaki Sagawa ,  Ikunoshin Kato

IPC分类号： A61K31/7048 ,  A61K31/353 ,  A61K31/12 ,  A61K47/00

CPC分类号： A61K31/365 ,  A23K20/111 ,  A23K20/116 ,  A23L33/10 ,  A61K31/121 ,  A61K31/222 ,  A61K31/341 ,  A61K31/343 ,  A61K31/351 ,  A61K31/352 ,  A61K31/366 ,  A61K31/381 ,  C07C49/84 ,  C07C69/017 ,  C07D307/46

摘要： A therapeutic agent and prophylactic agent for a disease accompanying an abnormality in an amount of insulin or insulin response, an agent for an insulin-mimetic action, a food, beverage and feed, an agent for enhancing glucose uptake into a cell, and an agent for inducing differentiation into an adipocyte, characterized in that each comprises as an effective ingredient at least one compound selected from the group consisting of a chalcone compound, an acetophenone compound, a coumarin compound, a phthalide compound, derivatives thereof, and pharmacologically acceptable salts thereof.

摘要翻译： 用于伴随胰岛素或胰岛素反应量异常的疾病的治疗剂和预防剂，胰岛素模拟作用剂，食品，饮料和饲料，用于增强葡萄糖摄入细胞的药剂和药剂 用于诱导分化为脂肪细胞的方法，其特征在于，每种包含作为有效成分的至少一种选自查耳酮化合物，苯乙酮化合物，香豆素化合物，苯酞化合物，其衍生物和其药理学上可接受的盐的化合物 。

公开(公告)号：US08927273B2

公开(公告)日：2015-01-06

申请号：US10568745

申请日：2004-08-19

申请人： Mitsuko Ideno ,  Nobuko Muraki ,  Kinuko Ogawa ,  Masayuki Kishimoto ,  Tatsuji Enoki ,  Hiroaki Sagawa ,  Ikunoshin Kato

发明人： Mitsuko Ideno ,  Nobuko Muraki ,  Kinuko Ogawa ,  Masayuki Kishimoto ,  Tatsuji Enoki ,  Hiroaki Sagawa ,  Ikunoshin Kato

IPC分类号： C12N5/07 ,  C12N5/0783

CPC分类号： C12N5/0636 ,  C12N2501/58

摘要： The present invention provides a method for preparing a cytotoxic lymphocyte characterized in that the method comprises the step of carrying out at least one step selected from induction, maintenance and expansion of a cytotoxic lymphocyte using a medium containing serum and plasma at a total concentration of 0% by volume or more and less than 5% by volume, in the presence of fibronectin, a fragment thereof or a mixture thereof.

公开(公告)号：US20070060641A1

公开(公告)日：2007-03-15

申请号：US10557268

申请日：2004-05-18

申请人： Tatsuji Enoki ,  Eiji Kobayashi ,  Kinuko Ogawa ,  Yoko Kudo ,  Masashige Tanabe ,  Hiromu Ohnogi ,  Hiroaki Sagawa ,  Ikunoshin Kato

发明人： Tatsuji Enoki ,  Eiji Kobayashi ,  Kinuko Ogawa ,  Yoko Kudo ,  Masashige Tanabe ,  Hiromu Ohnogi ,  Hiroaki Sagawa ,  Ikunoshin Kato

IPC分类号： A61K31/343 ,  A61K31/225 ,  A61K31/19 ,  A61K31/192 ,  A61K31/11

CPC分类号： A61K31/11 ,  A23K20/00 ,  A23L33/10

摘要： The present invention relates to a therapeutic agent or prophylactic agent for a disease accompanying an abnormality in an amount of insulin or insulin response, an insulin-mimetic action agent, a food, beverage, or feed, an agent for enhancement of glucose uptake into a cell, and an agent for inducing differentiation into an adipocyte, each comprising as an effective ingredient at least one compound selected from the group consisting of specified compounds having an insulin-mimetic action, derivatives thereof, and pharmacologically acceptable salts thereof.

摘要翻译： 本发明涉及一种伴随胰岛素或胰岛素反应量异常的疾病的治疗剂或预防剂，胰岛素模拟作用剂，食物，饮料或饲料，用于增强葡萄糖摄入 细胞和用于诱导分化成脂肪细胞的药剂，其各自包含至少一种选自具有胰岛素模拟作用的特定化合物，其衍生物和其药理学上可接受的盐的至少一种化合物作为有效成分。

公开(公告)号：US20090221077A1

公开(公告)日：2009-09-03

申请号：US10568745

申请日：2004-08-19

申请人： Mitsuko Ideno ,  Nobuko Muraki ,  Kinuko Ogawa ,  Masayuki Kishimoto ,  Tatsuji Enoki ,  Hiroaki Sagawa ,  Ikunoshin Kato

发明人： Mitsuko Ideno ,  Nobuko Muraki ,  Kinuko Ogawa ,  Masayuki Kishimoto ,  Tatsuji Enoki ,  Hiroaki Sagawa ,  Ikunoshin Kato

IPC分类号： C12N15/86 ,  C12N5/00 ,  C12N5/02 ,  C12N15/00 ,  C07K14/00 ,  C07H21/00

CPC分类号： C12N5/0636 ,  C12N2501/58

摘要： The present invention provides a method for preparing a cytotoxic lymphocyte characterized in that the method comprises the step of carrying out at least one step selected from induction, maintenance and expansion of a cytotoxic lymphocyte using a medium containing serum and plasma at a total concentration of 0% by volume or more and less than 5% by volume, in the presence of fibronectin, a fragment thereof or a mixture thereof.

摘要翻译： 本发明提供了一种制备细胞毒性淋巴细胞的方法，其特征在于该方法包括使用含有总浓度为0的血清和血浆的培养基进行选自诱导，维持和扩增细胞毒性淋巴细胞的至少一个步骤的步骤 在纤维连接蛋白，其片段或其混合物的存在下，以体积计或更多且小于5体积％。

公开(公告)号：US20080044498A1

公开(公告)日：2008-02-21

申请号：US11905945

申请日：2007-10-05

申请人： Tatsuji Enoki ,  Kinuko Ogawa ,  Hiromu Ohnogi ,  Katsumi Sugiyama ,  Nobuko Muraki ,  Hiroaki Sagawa ,  Ikunoshin Kato

发明人： Tatsuji Enoki ,  Kinuko Ogawa ,  Hiromu Ohnogi ,  Katsumi Sugiyama ,  Nobuko Muraki ,  Hiroaki Sagawa ,  Ikunoshin Kato

IPC分类号： A61K36/232

CPC分类号： A61K36/232 ,  A23L2/52 ,  A23L33/105 ,  A23V2002/00 ,  A23V2200/328 ,  A23V2250/21

摘要： The present invention relates to a therapeutic agent or prophylactic agent for a disease accompanying an abnormality in an amount of insulin or insulin response, an insulin-mimetic action agent, a food, beverage, or feed for treating or preventing a disease accompanying an abnormality in an amount of insulin or insulin response, an agent for enhancement of glucose uptake into a cell, and an agent for induction of an adipocyte differentiation, each comprising as an effective ingredient a processed product derived from a plant belonging to Umbelliferae.

摘要翻译： 本发明涉及一种伴随胰岛素或胰岛素反应量异常的疾病的治疗剂或预防剂，用于治疗或预防伴随异常的疾病的胰岛素模拟作用剂，食品，饮料或饲料 一定量的胰岛素或胰岛素反应，用于增强葡萄糖摄入细胞的药剂和用于诱导脂肪细胞分化的药剂，其各自包含衍生自属于伞形属植物的植物的加工产品作为有效成分。

公开(公告)号：US20060034949A1

公开(公告)日：2006-02-16

申请号：US10524015

申请日：2003-08-06

申请人： Tatsuji Enoki ,  Kinuko Ogawa ,  Hiromu Ohnogi ,  Katsumi Sugiyama ,  Nobuko Muraki ,  Hiroaki Sagawa ,  Ikunoshin Kato

发明人： Tatsuji Enoki ,  Kinuko Ogawa ,  Hiromu Ohnogi ,  Katsumi Sugiyama ,  Nobuko Muraki ,  Hiroaki Sagawa ,  Ikunoshin Kato

IPC分类号： A61K36/232

CPC分类号： A61K36/232 ,  A23L2/52 ,  A23L33/105 ,  A23V2002/00 ,  A23V2200/328 ,  A23V2250/21

摘要： The present invention relates to a therapeutic agent or prophylactic agent for a disease accompanying an abnormality in an amount of insulin or insulin response, an insulin-mimetic action agent, a food, beverage, or feed for treating or preventing a disease accompanying an abnormality in an amount of insulin or insulin response, an agent for enhancement of glucose uptake into a cell, and an agent for induction of an adipocyte differentiation, each comprising as an effective ingredient a processed product derived from a plant belonging to Umbelliferae.

摘要翻译： 本发明涉及一种伴随胰岛素或胰岛素反应量异常的疾病的治疗剂或预防剂，用于治疗或预防伴随异常的疾病的胰岛素模拟作用剂，食品，饮料或饲料 一定量的胰岛素或胰岛素反应，用于增强葡萄糖摄入细胞的药剂和用于诱导脂肪细胞分化的药剂，其各自包含衍生自属于伞形属植物的植物的加工产品作为有效成分。