公开(公告)号：US5122197A

公开(公告)日：1992-06-16

申请号：US573565

申请日：1990-08-28

申请人： Hiroshi Asai ,  Ichiro Kitayama ,  Kouji Mineshita ,  Ken Okazaki ,  Akira Ohtsuka ,  Yuichi Nishiyama ,  Yasuo Uosaki

发明人： Hiroshi Asai ,  Ichiro Kitayama ,  Kouji Mineshita ,  Ken Okazaki ,  Akira Ohtsuka ,  Yuichi Nishiyama ,  Yasuo Uosaki

IPC分类号： C22C37/06 ,  F16D69/02

CPC分类号： F16D69/027 ,  C22C37/06

摘要： A cast-iron product has a composition of 4.3-4.9 wt. % Carbon Equivalent (CE), 0.25-0.5 wt. % Chromium (Cr), 0.05-0.12 wt. % Tin (Sn), 0.4-1.2 wt. % Manganese (Mn), 0-0.1 wt. % Phosphorus (P), and 0-0.15 wt. % Sulfur (S), with the balance being Iron (Fe). A brake assembly comprises a sliding element made of such a cast iron, and the sliding element is adapted to slideably contact with a friction element or elements made of non-asbestos material and constitute the assembly. Further, a method of producing a cast iron product comprises the steps of casting a cast iron having a composition of 4.3-4.9 wt. % Carbon Equivalent (CE), 0.25-0.5 wt. % Chromium (Cr), 0.05-0.12 wt. % Tin (Sn), 0.4-1.2 wt. % Manganese (Mn), 0-0.1 wt. % Phosphorus (P), and 0-0.15 wt. % Sulfur (S), with the balance being Iron (Fe), releasing a mold at a temperature not less than A.sub.1 allotropic transformation temperature, and cooling the cast iron at a relatively high cooling rate.

摘要翻译： 铸铁产品的组成为4.3-4.9wt。 ％碳当量（CE），0.25-0.5重量％ ％铬（Cr），0.05-0.12重量％ ％锡（Sn），0.4-1.2重量％ ％锰（Mn），0-0.1重量％ 磷（P）和0-0.15重量％ ％硫（S），余量为铁（Fe）。 制动组件包括由这种铸铁制成的滑动元件，并且滑动元件适于与由非石棉材料制成的摩擦元件滑动接触并构成组件。 此外，制造铸铁制品的方法包括以下步骤：铸造组成为4.3-4.9重量％的铸铁。 ％碳当量（CE），0.25-0.5重量％ ％铬（Cr），0.05-0.12重量％ ％锡（Sn），0.4-1.2重量％ ％锰（Mn），0-0.1重量％ 磷（P）和0-0.15重量％ ％硫（S），余量为铁（Fe），在不低于A1同素异形转变温度的温度下释放模具，并以相对较高的冷却速度冷却铸铁。

公开(公告)号：US08343548B2

公开(公告)日：2013-01-01

申请号：US11888529

申请日：2007-08-01

申请人： Fumie Kusaki ,  Takafumi Hoshino ,  Naosuke Maruyama ,  Yuichi Nishiyama ,  Ikuo Fukui ,  Hiroshi Umezawa

发明人： Fumie Kusaki ,  Takafumi Hoshino ,  Naosuke Maruyama ,  Yuichi Nishiyama ,  Ikuo Fukui ,  Hiroshi Umezawa

IPC分类号： A61K9/14 ,  A61K9/50

CPC分类号： A61K9/1652 ,  A61K9/1623 ,  A61K9/2018 ,  A61K9/2054 ,  A61K9/2059 ,  A61K31/44

摘要： Provided are a solid dosage form comprising an enteric solid dispersion that allows a drug in the preparation to be rapidly dissolved without compromising the solubility of the solid dispersion, and a method for producing the same. More specifically, provided is a solid dosage form comprising an enteric solid dispersion comprising a poorly soluble drug, an enteric polymer and a disintegrant, wherein the disintegrant is low-substituted hydroxypropylcellulose having an average particle size of 10 to 100 μm and a specific surface area measured by BET method of at least 1.0 m2/g. Moreover, provided is a method for producing a solid dosage form comprising an enteric solid dispersion, the method comprising steps of: spraying an enteric polymer solution in which a poorly soluble drug has been dispersed or dissolved, on a powder of low-substituted hydroxypropylcellulose having an average particle size of 10 to 100 μm and a specific surface area measured by BET method of at least 1.0 m2/g and serving as a disintegrant; and granulating the resultant; and drying.

摘要翻译： 提供了一种固体剂型，其包含允许制剂中的药物快速溶解而不损害固体分散体的溶解性的肠溶固体分散体及其制备方法。 更具体地，提供了包含包含难溶性药物，肠溶性聚合物和崩解剂的肠溶性固体分散体的固体剂型，其中所述崩解剂是平均粒径为10〜100μm的低取代羟丙基纤维素，比表面积 通过BET法测量为至少1.0m 2 / g。 此外，提供了一种生产包含肠溶固体分散体的固体剂型的方法，所述方法包括以下步骤：将难溶性药物已经分散或溶解的肠溶性聚合物溶液喷雾到具有 平均粒径为10〜100μm，BET法测定的比表面积为1.0m 2 / g以上，作为崩解剂; 并造成结果; 并干燥。

公开(公告)号：US20090176277A1

公开(公告)日：2009-07-09

申请号：US11569360

申请日：2005-08-22

申请人： Kazuhisa Hayakawa ,  Yuichi Nishiyama ,  Tatsuo Endo

发明人： Kazuhisa Hayakawa ,  Yuichi Nishiyama ,  Tatsuo Endo

IPC分类号： C12P19/00 ,  C07H1/00

CPC分类号： C12P19/14 ,  C08B15/00 ,  C12P19/04

摘要： Provided is a method for preparing a cellulose derivative having solubility improved and therefore having less undissolved floating portions when the derivative is added into water. More specifically, provided is a method for preparing a cellulose derivative, comprising a step of depolymerizing a cellulose derivative to produce a depolymerized cellulose derivative having a viscosity at 20° C. in a 2% by weight aqueous solution of the depolymerized cellulose derivative reduced by at least 10% compared with that of the cellulose derivative before the depolymerization so that the number of undissolved floating portions in the aqueous solution of the depolymerized cellulose derivative is decreased compared with that of the cellulose derivative before the depolymerization. Depolymerization is effected preferably by an acid, alkali or enzyme.

摘要翻译： 本发明提供一种制备具有溶解度提高的纤维素衍生物的方法，并且当将衍生物加入到水中时具有较少的未溶解的浮动部分。 更具体地说，提供了一种制备纤维素衍生物的方法，包括将纤维素衍生物解聚以在20℃下粘度为2重量％的解聚的纤维素衍生物的水溶液中还原的解聚的纤维素衍生物的步骤 与解聚前的纤维素衍生物相比，至少10％以上，与解聚前的纤维素衍生物相比，解聚纤维素衍生物的水溶液中未溶解的浮动部分的数量减少。 解聚优选通过酸，碱或酶进行。

公开(公告)号：US06258799B1

公开(公告)日：2001-07-10

申请号：US09404754

申请日：1999-09-24

申请人： Hiroyasu Kokubo ,  Yuichi Nishiyama

发明人： Hiroyasu Kokubo ,  Yuichi Nishiyama

IPC分类号： A61K3170

CPC分类号： A61K9/2866

摘要： An aqueous coating composition comprising hydroxypropyl methyl cellulose trimellitate typically having a mean particle size of up to 10 &mgr;m and a plasticizer is applied to a solid pharmaceutical preparation to form a coating film having acid resistance and solubility at about pH 4. The coated preparation has an improved bioavailability.

摘要翻译： 将包含平均粒度最高达10μm的羟丙基甲基纤维素偏苯三酸酯和增塑剂的水性涂料组合物施用于固体药物制剂以形成在约pH 4下具有耐酸性和溶解性的涂膜。涂布制剂具有 提高生物利用度。

公开(公告)号：US20130305924A1

公开(公告)日：2013-11-21

申请号：US13981387

申请日：2012-01-17

申请人： Shiko Nakamura ,  Tomoya Muramoto ,  Yuichi Nishiyama ,  Shinya Okuno

发明人： Shiko Nakamura ,  Tomoya Muramoto ,  Yuichi Nishiyama ,  Shinya Okuno

IPC分类号： B01D53/14

CPC分类号： B01D53/1425 ,  B01D53/1475 ,  Y02A50/2342 ,  Y02C10/06

摘要： A recovery apparatus of carbon dioxide comprises: an absorption column which brings a gas containing carbon dioxide into contact with an absorbing liquid and allows the absorbing liquid to absorb carbon dioxide; a regeneration column for regenerating the absorbing liquid, by causing the absorbing liquid having carbon dioxide absorbed in the absorption column to release carbon dioxide; a circulation system which circulates the absorbing liquid so that the absorbing liquid flowing from the absorption column returns to the absorption column through the regeneration column; and a steam supply system which generates steam available for a heat source that regenerates the absorbing liquid, using at least one of the absorbing liquid that returns to the absorption column by the circulation system and the absorbing liquid in the absorption column, and supplies the steam to the regeneration column. Absorption of carbon dioxide and release/regeneration are repeated, high temperature steam is generated from the absorbing liquid that returns to the absorption column and the absorbing liquid in the absorption column, and the steam is provided to the regeneration column to use as a heat source for regenerating the absorbing liquid.

摘要翻译： 二氧化碳回收装置包括：吸收塔，其使含有二氧化碳的气体与吸收液体接触并允许吸收液体吸收二氧化碳; 用于再生吸收液体的再生塔，通过使吸收塔吸收的二氧化碳的吸收液体释放二氧化碳; 循环系统，其使吸收液体循环，使得从吸收塔流出的吸收液体通过再生塔返回吸收塔; 以及蒸汽供应系统，其使用再循环吸收液体的热源产生蒸汽，使用通过循环系统和吸收塔中的吸收液体返回到吸收塔的吸收液中的至少一种，并将蒸汽 到再生柱。 重复二氧化碳的吸收和释放/再生，从吸收塔返回到吸收塔和吸收塔中的吸收液体的吸收液体产生高温蒸汽，并将蒸汽提供给再生塔以用作热源 用于再生吸收液体。

公开(公告)号：US20080038339A1

公开(公告)日：2008-02-14

申请号：US11888445

申请日：2007-08-01

申请人： Takafumi Hoshino ,  Fumie Kusaki ,  Naosuke Maruyama ,  Yuichi Nishiyama ,  Ikuo Fukui ,  Hiroshi Umezawa

发明人： Takafumi Hoshino ,  Fumie Kusaki ,  Naosuke Maruyama ,  Yuichi Nishiyama ,  Ikuo Fukui ,  Hiroshi Umezawa

IPC分类号： A61K9/10 ,  A61K47/30 ,  A61K47/38

CPC分类号： A61K9/2054 ,  A61K31/44

摘要： Provided are a solid dosage form comprising a solid dispersion that allows a drug in the preparation to be rapidly dissolved without compromising the solubility of the solid dispersion, and a method for producing the same. More specifically, provided is a solid dosage form comprising a solid dispersion, the dispersion comprising: a poorly soluble drug, a water-soluble polymer and a disintegrant, wherein the disintegrant is low-substituted hydroxypropylcellulose having an average particle size of 10 to 100 μm and a specific surface area measured by BET method of at least 1.0 m2/g. Moreover, provided is a method for producing a solid dosage form comprising a solid dispersion, the method comprising steps of: spraying a water-soluble polymer solution in which a poorly soluble drug has been dispersed or dissolved, on a powder of low-substituted hydroxypropylcellulose having an average particle size of 10 to 100 μm and a specific surface area measured by BET method of at least 1.0 m2/g and serving as a disintegrant and granulating the resultant; and drying.

摘要翻译： 提供了一种固体剂型及其制备方法，该固体分散体允许制剂中的药物快速溶解而不损害固体分散体的溶解性。 更具体地，提供了包含固体分散体的固体剂型，所述分散体包含：难溶性药物，水溶性聚合物和崩解剂，其中所述崩解剂是平均粒度为10至100μm的低取代羟丙基纤维素 并且通过BET法测量的比表面积为至少1.0m 2 / g。 此外，提供了一种制备包含固体分散体的固体剂型的方法，所述方法包括以下步骤：将难溶性药物已经分散或溶解的水溶性聚合物溶液喷雾到低取代羟丙基纤维素粉末上 平均粒径为10〜100μm，通过BET法测定的比表面积为至少1.0m 2 / g，作为崩解剂，造粒; 并干燥。

公开(公告)号：US20070292509A1

公开(公告)日：2007-12-20

申请号：US11764084

申请日：2007-06-15

申请人： Mutsunori Tanji ,  Tadashi Matsui ,  Shuichiro Yuasa ,  Yuichi Nishiyama ,  Yuichi Ito ,  Ikuo Fukui

发明人： Mutsunori Tanji ,  Tadashi Matsui ,  Shuichiro Yuasa ,  Yuichi Nishiyama ,  Yuichi Ito ,  Ikuo Fukui

IPC分类号： A61K9/26

CPC分类号： A61K9/1688 ,  A61K9/1652 ,  A61K9/5026 ,  A61K9/5042 ,  A61K9/5073

摘要： The present invention is an enteric coated granule having controlled dissolution in water even at a small coating amount; and a preparation method thereof. More specifically, provided are an enteric coated granule comprising a raw granule or a granule comprising a raw granule and at least one layer covering the raw granule, a first enteric layer covering the raw granule or the granule, and a second enteric layer formed over the first enteric layer, wherein the first and the second enteric layers comprise a first and a second hydroxypropylmethyl cellulose acetate succinates (HPMCASs) different in solubility pH, respectively, and the solubility pH value of the second HPMCAS of the second enteric layer is lower than that of the first enteric layer; and a preparation method comprising steps of covering a raw granule or a granule comprising a raw granule and at least one layer covering the raw granule with an enteric coating agent comprising a first HPMCAS to form a first enteric layer; and forming, over the first enteric layer, a second coating layer by using a second enteric coating agent comprising a second HPMCAS having a lower solubility pH value than that of the first HPMCAS.

摘要翻译： 本发明是即使以小的涂布量控制溶解在水中的肠溶衣颗粒剂; 及其制备方法。 更具体地，提供一种肠溶包衣颗粒，其包含原料颗粒或颗粒，其包含原料颗粒和覆盖原料颗粒的至少一层，覆盖原料颗粒或颗粒的第一肠溶层和形成在该颗粒上的第二肠溶层 第一肠溶层，其中第一和第二肠溶层分别包含溶解度pH不同的第一和第二羟丙基甲基纤维素乙酸酯琥珀酸酯（HPMCAS），第二肠溶层的第二HPMCAS的溶解度pH值低于第二肠溶层的溶解度pH值 的第一肠溶层; 以及包括以下步骤的方法，其包括用包含原料颗粒的原料颗粒或包含原料颗粒的至少一层的颗粒与包含第一HPMCAS的肠溶包衣剂一起覆盖以形成第一肠溶层; 并且通过使用包含比第一HPMCAS具有更低的溶解度pH值的第二HPMCAS的第二肠溶包衣剂，在第一肠溶层上形成第二涂层。

公开(公告)号：US5372998A

公开(公告)日：1994-12-13

申请号：US31347

申请日：1993-03-12

申请人： Hiroyasu Kokubo ,  Yuichi Nishiyama ,  Hiroaki Muto

发明人： Hiroyasu Kokubo ,  Yuichi Nishiyama ,  Hiroaki Muto

IPC分类号： A61K47/38 ,  A61K9/28 ,  A61K9/36 ,  A61K9/62 ,  A01N43/04

CPC分类号： A61K9/2866

摘要： The present invention provides a powdery starting material for preparing a drug-coating solution, which has high safety as a drug component and is very rapidly dissolved in room temperature water upon preparation of a coating solution. The powdery starting material for preparing a drug-coating solution comprises hydroxypropylmethyl cellulose and/or methyl cellulose particles having an average particle size ranging from 200 to 1000 .mu.m and whose content of particles having a particle size of 75 .mu.m or smaller is not more than 30% by weight. More preferably, the viscosity of a 2% by weight aqueous solution of the powdery starting material as determined at room temperature ranges from 2 to 60 cP and preferably 2 to 20 cP.

摘要翻译： 本发明提供了一种制备药物涂层溶液的粉末状原料，其作为药物成分具有高安全性，并且在制备涂布溶液时非常快速地溶解在室温水中。 用于制备药物包衣溶液的粉末状原料包括平均粒度为200-1000μm的羟丙基甲基纤维素和/或甲基纤维素颗粒，其粒径为75μm或更小的颗粒的含量不多 超过30重量％。 更优选地，在室温下测定的粉末原料的2重量％水溶液的粘度为2至60cP，优选为2至20cP。

公开(公告)号：US09375676B2

公开(公告)日：2016-06-28

申请号：US13981387

申请日：2012-01-17

申请人： Shiko Nakamura ,  Tomoya Muramoto ,  Yuichi Nishiyama ,  Shinya Okuno

发明人： Shiko Nakamura ,  Tomoya Muramoto ,  Yuichi Nishiyama ,  Shinya Okuno

IPC分类号： B01D53/14

CPC分类号： B01D53/1425 ,  B01D53/1475 ,  Y02A50/2342 ,  Y02C10/06

摘要： A recovery apparatus of carbon dioxide includes: an absorption column contacting a carbon dioxide-containing gas into contact with an absorbing liquid and allowing the absorbing liquid to absorb carbon dioxide; a regeneration column for regenerating the absorbing liquid to release carbon dioxide; a circulation system which circulates the absorbing liquid to flow from the absorption column and return to the absorption column through the regeneration column; and a steam supply system which generates steam available for a heat source that regenerates the absorbing liquid, using the absorbing liquid that returns to the absorption column and/or the absorbing liquid in the absorption column, and supplies the steam to the regeneration column. High temperature steam is generated from the absorbing liquid and is provided to the regeneration column to use as a heat source for regenerating the absorbing liquid.

摘要翻译： 二氧化碳的回收装置包括：使含有二氧化碳的气体与吸收液体接触并使吸收液体吸收二氧化碳的吸收塔; 用于再生吸收液体以释放二氧化碳的再生塔; 循环系统，其使吸收液体循环，从吸收塔流出并通过再生塔返回吸收塔; 以及蒸汽供应系统，其产生可用于再生吸收液体的热源的蒸汽，使用返回到吸收塔中的吸收液体和/或吸收塔中的吸收液体，并将蒸汽供应到再生塔。 从吸收液体产生高温蒸汽，并提供给再生塔，以用作再生吸收液体的热源。

公开(公告)号：US09095513B2

公开(公告)日：2015-08-04

申请号：US11764084

申请日：2007-06-15

申请人： Mutsunori Tanji ,  Tadashi Matsui ,  Shuichiro Yuasa ,  Yuichi Nishiyama ,  Yuichi Ito ,  Ikuo Fukui

发明人： Mutsunori Tanji ,  Tadashi Matsui ,  Shuichiro Yuasa ,  Yuichi Nishiyama ,  Yuichi Ito ,  Ikuo Fukui

IPC分类号： A61K9/16 ,  A61K9/50

CPC分类号： A61K9/1688 ,  A61K9/1652 ,  A61K9/5026 ,  A61K9/5042 ,  A61K9/5073

摘要： The present invention is an enteric coated granule having controlled dissolution in water even at a small coating amount; and a preparation method thereof. More specifically, provided are an enteric coated granule comprising a raw granule or a granule comprising a raw granule and at least one layer covering the raw granule, a first enteric layer covering the raw granule or the granule, and a second enteric layer formed over the first enteric layer, wherein the first and the second enteric layers comprise a first and a second hydroxypropylmethyl cellulose acetate succinates (HPMCASs) different in solubility pH, respectively, and the solubility pH value of the second HPMCAS of the second enteric layer is lower than that of the first enteric layer; and a preparation method comprising steps of covering a raw granule or a granule comprising a raw granule and at least one layer covering the raw granule with an enteric coating agent comprising a first HPMCAS to form a first enteric layer; and forming, over the first enteric layer, a second coating layer by using a second enteric coating agent comprising a second HPMCAS having a lower solubility pH value than that of the first HPMCAS.

摘要翻译： 本发明是即使以小的涂布量控制溶解在水中的肠溶衣颗粒剂; 及其制备方法。 更具体地，提供一种肠溶包衣颗粒，其包含原料颗粒或颗粒，其包含原料颗粒和覆盖原料颗粒的至少一层，覆盖原料颗粒或颗粒的第一肠溶层和形成在该颗粒上的第二肠溶层 第一肠溶层，其中第一和第二肠溶层分别包含溶解度pH不同的第一和第二羟丙基甲基纤维素乙酸琥珀酸酯（HPMCAS），第二肠溶层的第二HPMCAS的溶解度pH值低于第二肠溶层的溶解度pH值 的第一肠溶层; 以及包括以下步骤的方法，其包括用包含原料颗粒的原料颗粒或包含原料颗粒的至少一层的颗粒与包含第一HPMCAS的肠溶包衣剂一起覆盖以形成第一肠溶层; 并且通过使用包含比第一HPMCAS具有更低的溶解度pH值的第二HPMCAS的第二肠溶包衣剂，在第一肠溶层上形成第二涂层。