Method for producing alkylsulfinylbenzamides and
1,2-benzisothiazol-3-ones
    5.
    发明授权
    Method for producing alkylsulfinylbenzamides and 1,2-benzisothiazol-3-ones 失效
    烷基亚磺酰基苯甲酰胺和1,2-苯并异噻唑-3-酮的制备方法

    公开(公告)号:US5672751A

    公开(公告)日:1997-09-30

    申请号:US581109

    申请日:1995-12-29

    摘要: A method for producing an alkylthiobenzamide by carrying out a reaction of a halobenzamide with an alkanethiol in the presence of a base in a heterogeneous solvent; a method for producing an alkylsulfinylbenzamide by carrying out a reaction of an alkylthiobenzamide with a halogen in a heterogeneous solvent; a method for producing an alkylsulfinylbenzamide by carrying out a reaction of a halobenzamide with an alkanethiol in the presence of a base in a heterogeneous solvent and a subsequent reaction with a halogen; and a method for producing a 1,2-benzisothiazol-3-one by carrying out a reaction of a 2-(alkylthio)benzamide with a halogenating agent.

    摘要翻译: 一种烷基硫代苯甲酰胺的制备方法,其通过在非均相溶剂中在碱存在下进行卤代苯甲酰胺与烷硫醇的反应; 通过在异质溶剂中进行烷基硫代苯甲酰胺与卤素的反应制备烷基亚磺酰基苯甲酰胺的方法; 烷基亚磺酰基苯甲酰胺的制备方法,其通过在碱存在下在非均相溶剂中进行卤代苯甲酰胺与烷硫醇的反应,随后与卤素反应; 和通过2-(烷硫基)苯甲酰胺与卤化剂的反应制备1,2-苯并异噻唑-3-酮的方法。

    Method for producing 1,2-benzisothiazol-3-ones
    6.
    发明授权
    Method for producing 1,2-benzisothiazol-3-ones 失效
    1,2-苯并异噻唑-3-酮的制备方法

    公开(公告)号:US5773626A

    公开(公告)日:1998-06-30

    申请号:US718132

    申请日:1996-09-18

    IPC分类号: C07D275/04 C07D275/06

    CPC分类号: C07D275/04 C07D275/06

    摘要: A method for producing a 1,2-benzisothiazol-3-one, having the steps of carrying out a reaction of a 2-(alkylthio)benzaldehyde with a hydroxylamine to give a 2-(alkylthio)benzaldehyde oxime and carrying out a reaction of the 2-(alkylthio)benzaldehyde oxime with a halogenating agent; and a method for producing a 1,2-benzisothiazol-3-one, having the steps of carrying out a reaction of a 2-halobenzonitrile with an alkanethiol in a heterogeneous solvent system in the presence of a base to give a 2-(alkylthio)benzonitrile and carrying out a reaction of the 2-(alkylthio)benzonitrile with an halogenating agent in the presence of water.

    摘要翻译: 一种1,2-苯并异噻唑-3-酮的制备方法,其具有2-(烷硫基)苯甲醛与羟胺反应的步骤,得到2-(烷硫基)苯甲醛肟,进行 2-(烷硫基)苯甲醛肟与卤化剂; 和1,2-苯并异噻唑-3-酮的制备方法,其具有以下步骤:在非均相溶剂体系中,在碱的存在下,使2-卤代苄腈与链烷硫醇进行反应,得到2-(烷硫基 )苄腈,并在水存在下进行2-(烷硫基)苄腈与卤化剂的反应。

    Method for producing alkylsulfinylbenzamides and
1,2-benzisothiazol-3-ones
    7.
    发明授权
    Method for producing alkylsulfinylbenzamides and 1,2-benzisothiazol-3-ones 失效
    烷基亚磺酰基苯甲酰胺和1,2-苯并异噻唑-3-酮的制备方法

    公开(公告)号:US5508416A

    公开(公告)日:1996-04-16

    申请号:US342038

    申请日:1994-11-17

    摘要: A method for producing an alkylthiobenzamide by carrying out a reaction of a halobenzamide with an alkanethiol in the presence of a base in a heterogeneous solvent; a method for producing an alkylsulfinylbenzamide by carrying out a reaction of an alkylthiobenzamide with a halogen in a heterogeneous solvent; a method for producing an alkylsulfinylbenzamide by carrying out a reaction of a halobenzamide with an alkanethiol in the presence of a base in a heterogeneous solvent and a subsequent reaction with a halogen; and a method for producing a 1,2-benzisothiazol-3-one by carrying out a reaction of a 2-(alkylthio)benzamide with a halogenating agent.

    摘要翻译: 一种烷基硫代苯甲酰胺的制备方法,其通过在非均相溶剂中在碱存在下进行卤代苯甲酰胺与烷硫醇的反应; 通过在异质溶剂中进行烷基硫代苯甲酰胺与卤素的反应制备烷基亚磺酰基苯甲酰胺的方法; 烷基亚磺酰基苯甲酰胺的制备方法,其通过在碱存在下在非均相溶剂中进行卤代苯甲酰胺与烷硫醇的反应,随后与卤素反应; 和通过2-(烷硫基)苯甲酰胺与卤化剂的反应制备1,2-苯并异噻唑-3-酮的方法。

    Processes for producing isothiazole derivatives
    8.
    发明授权
    Processes for producing isothiazole derivatives 失效
    异噻唑衍生物的制备方法

    公开(公告)号:US5856504A

    公开(公告)日:1999-01-05

    申请号:US836697

    申请日:1997-05-19

    IPC分类号: C07D275/04

    CPC分类号: C07D275/04

    摘要: A method for producing a 1,2-benzisothiazole characterized by treating a 2-(alkylthio)benzaldehyde oxime with a halogen compound; a method for producing a 3-halo-1,2-benzisothiazole characterized by treating a 1,2-benzisothiazole with a halogenating agent; and a method for producing a 1-(1,2-benzisothiazol-3-yl)piperazine characterized by reacting the obtained 3-halo-1,2-benzisothiazoles with a piperazine. By the method of the present invention, 1,2-benzisothiazoles and 3-halo-1,2-benzisothiazoles, which are useful as intermediates for pharmaceutical compositions such as psychotropic agents, and 1-(1,2-benzisothiazole-3-yl)piperazines synthesized therefrom can be obtained in a high yield without using expensive starting materials by shorter and simpler process than conventional methods.

    摘要翻译: PCT No.PCT / JP95 / 02484第 371日期1997年5月19日 102(e)日期1997年5月19日PCT提交1995年12月4日PCT公布。 第WO96 / 17834号公报 日期1996年6月13日制备1,2-苯并异噻唑的方法,其特征在于用卤素化合物处理2-(烷硫基)苯甲醛肟; 其特征在于用卤化剂处理1,2-苯并异噻唑的3-卤代-1,2-苯并异噻唑的制备方法。 以及1-(1,2-苯并异噻唑-3-基)哌嗪的制造方法,其特征在于使得到的3-卤代-1,2-苯并异噻唑与哌嗪反应。 通过本发明的方法,1,2-苯并异噻唑和3-卤代-1,2-苯并异噻唑可用作药物组合物如精神药物的中间体和1-(1,2-苯并异噻唑-3-基 )哌嗪可以通过比常规方法更短和更简单的方法以高产率获得而不使用昂贵的起始原料。

    Method for producing alkylsulfinylbenzamides and 1-2
benzisothiazol-3-ones
    9.
    发明授权
    Method for producing alkylsulfinylbenzamides and 1-2 benzisothiazol-3-ones 失效
    烷基亚磺酰基苯甲酰胺和1-2苯并异噻唑-3-酮的制备方法

    公开(公告)号:US5744609A

    公开(公告)日:1998-04-28

    申请号:US831533

    申请日:1997-04-07

    摘要: A method for producing an alkylthiobenzamide by carrying out a reaction of a halobenzamide with an alkanethiol in the presence of a base in a heterogeneous solvent; a method for producing an alkylsulfinylbenzamide by carrying out a reaction of an alkylthiobenzamide with a halogen in a heterogeneous solvent; a method for producing an alkylsulfinylbenzamide by carrying cut a reaction of a halobenzamide with an alkanethiol in the presence of a base in a heterogeneous solvent and a subsequent reaction with a halogen; and a method for producing a 1,2-benzisothiazol-3-one by carrying out a reaction of a 2-(alkylthio)benzamide with a halogenating agent.

    摘要翻译: 一种烷基硫代苯甲酰胺的制备方法,其通过在非均相溶剂中在碱存在下进行卤代苯甲酰胺与烷硫醇的反应; 通过在异质溶剂中进行烷基硫代苯甲酰胺与卤素的反应制备烷基亚磺酰基苯甲酰胺的方法; 一种烷基亚磺酰基苯甲酰胺的制备方法,其通过在碱存在下在非均相溶剂中进行卤代苯甲酰胺与烷硫醇的反应,随后与卤素反应; 和通过2-(烷硫基)苯甲酰胺与卤化剂的反应制备1,2-苯并异噻唑-3-酮的方法。

    Method for producing 1,2-benzisothiazol-3-ones
    10.
    发明授权
    Method for producing 1,2-benzisothiazol-3-ones 失效
    1,2-苯并异噻唑-3-酮的制备方法

    公开(公告)号:US5633384A

    公开(公告)日:1997-05-27

    申请号:US467829

    申请日:1995-06-06

    IPC分类号: C07D275/04 C07D275/06

    CPC分类号: C07D275/04 C07D275/06

    摘要: A method for producing a 1,2-benzisothiazol-3-one, having the steps of carrying out a reaction of a 2-(alkylthio)benzaldehyde with a hydroxylamine to give a 2-(alkylthio)benzaldehyde oxime and carrying out a reaction of the 2-(alkylthio)benzaldehyde oxime with a halogenating agent; and a method for producing a 1,2-benzisothiazol-3-one, having the steps of carrying out a reaction of a 2-halobenzonitrile with an alkanethiol in a heterogeneous solvent system in the presence of a base to give a 2-(alkylthio)benzonitrile and carrying out a reaction of the 2-(alkylthio)benzonitrile with an halogenating agent in the presence of water.

    摘要翻译: 一种1,2-苯并异噻唑-3-酮的制备方法,其具有2-(烷硫基)苯甲醛与羟胺反应的步骤,得到2-(烷硫基)苯甲醛肟,进行 2-(烷硫基)苯甲醛肟与卤化剂; 和1,2-苯并异噻唑-3-酮的制备方法,其具有以下步骤:在非均相溶剂体系中,在碱的存在下,使2-卤代苄腈与链烷硫醇进行反应,得到2-(烷硫基 )苄腈,并在水存在下进行2-(烷硫基)苄腈与卤化剂的反应。