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25 条记录 (耗时 0.055 秒)

    Morphinan derivatives and pharmaceutical use thereof
    6.
    发明授权
    Morphinan derivatives and pharmaceutical use thereof 失效
    吗啡衍生物及其药物用途

    公开(公告)号：US06177438B1

    公开(公告)日：2001-01-23

    申请号：US08754750

    申请日：1996-11-21

    申请人： Hiroshi Nagase ,  Jun Hayakawa ,  Kuniaki Kawamura ,  Koji Kawai ,  Takashi Endoh

    发明人： Hiroshi Nagase ,  Jun Hayakawa ,  Kuniaki Kawamura ,  Koji Kawai ,  Takashi Endoh

    IPC分类号： C07D49108

    CPC分类号： C07D489/08 ,  C07D489/00

    摘要： A morphinan derivative or its pharmaceutically acceptable acid addition salt represented with, for example, and an analgesic, diuretic, antitussive and brain cell protector having its derivative or its salt as the active ingredient are described. The compound of the present invention possesses strong analgesic activity, diuretic action and antitussive action as a highly selective &kgr;-opioid agonist, allowing it to be used as a useful analgesic, diuretic and antitussive. On the other hand, the compound of the present invention also possesses remarkable cerebro-neuroprotective activity, thus allowing it be used as a useful cerebro-neuroprotective agents.

    摘要翻译： 描述了以其衍生物或其盐作为活性成分代表的吗啡喃衍生物或其药学上可接受的酸加成盐和镇痛药，利尿剂，镇咳药和脑细胞保护剂。本发明化合物具有强的止痛活性 ，利尿作用和镇咳作用作为高度选择性的κ-阿片样物质激动剂，使其可用作有用的止痛剂，利尿剂和镇咳药。 另一方面，本发明的化合物也具有显着的脑血管保护作用，因此可用作有用的脑血管保护剂。

    Agent for improving learning or memory
    10.
    发明授权
    Agent for improving learning or memory 失效
    改善学习或记忆的代理

    公开(公告)号：US06803366B2

    公开(公告)日：2004-10-12

    申请号：US10148489

    申请日：2002-05-30

    申请人： Kuniaki Kawamura ,  Hiroshi Nagase ,  Noriyuki Hirano ,  Junzo Kamei

    发明人： Kuniaki Kawamura ,  Hiroshi Nagase ,  Noriyuki Hirano ,  Junzo Kamei

    IPC分类号： A61K314375

    CPC分类号： C07D471/04 ,  A61K31/4738 ,  A61K31/4745 ,  A61K31/498

    摘要： Disclosed is an agent for improving learning and/or memory, which is useful for therapy of dementia accompanying disorder of memory due to a cerebrovascular disease, neurodegenerative disease such as Alzheimer's disease, endocrine disease, nutritional or metabolic disorder, infectious disease, drug addiction or the like. The agent for improving learning and/or memory according to the present invention comprises as an effective ingredient an isoquinoline derivative having a specific structure, such as (4aR, 12aR)-2-methyl-4a-(3-hydroxyphenyl)-1,2,3,4,4a,5,12,12a-octahydro-quinoline[2,3-g]isoquinoline or a pharmaceutically acceptable salt thereof.

    摘要翻译： 公开了一种用于改善学习和/或记忆的药剂，其用于治疗由于脑血管疾病，神经变性疾病如阿尔茨海默病，内分泌疾病，营养或代谢障碍，感染性疾病，药物成瘾引起的记忆障碍的痴呆症 类似。 根据本发明的用于改善学习和/或记忆的药剂包括作为有效成分的具有特定结构的异喹啉衍生物，例如（4aR，12aR）-2-甲基-4a-（3-羟基苯基）-1,2 ，3,4,4a，5,12,12a-八氢 - 喹啉[2,3-g]异喹啉或其药学上可接受的盐。