公开(公告)号：US5098417A

公开(公告)日：1992-03-24

申请号：US508178

申请日：1990-04-12

申请人： Hiroshi Yamazaki ,  Masao Miyazaki ,  Kouchi Matsumoto

发明人： Hiroshi Yamazaki ,  Masao Miyazaki ,  Kouchi Matsumoto

IPC分类号： A61F13/00 ,  A61L15/28 ,  A61L15/44

CPC分类号： A61L15/44 ,  A61F13/00063 ,  A61L15/28 ,  A61F2013/00463 ,  A61F2013/00906 ,  A61F2013/0091 ,  A61F2013/00927 ,  A61L2300/40

摘要： A wound dressing is provided herein for systemic administration of a physiologically- or biologically-active agent by controlled release of the agent into such wound. The wound dressing includes a substrate in the form of a fabric or cloth, at least a portion of which is cellulosic, which has been chemically modified to convert hydroxyl groups in the cellulosic portion to ionic-adsorbing sites. An ionic form of a physiologically- or biologically-active agent, namely an antibacterial agent, an antifungal agent, an analgesic agent, a tissue healant agent, a local anesthetic agent, an antibleeding agent, an enzyme or a vasoconstrictor is adsorbed in that substrate. Ionic bonds hold that agent temporarily to the substrate for controlled release therefrom in proportion to the amount of exudate in contact with the substrate. The ionic bonds are formed by adsorbing that agent on that substrate at room temperature. The ionic bonds disassociate upon contact with body exudate from wounds to which the wound dressing is applied by ion exchange with ions in the body exudate, thereby to release that agent in an amount in proportion to the amount of the exudate in contact with the substrate.

摘要翻译： 本文提供了一种伤口敷料，用于通过将药剂控制释放到这种伤口中来全身施用生理或生物活性剂。 伤口敷料包括织物或布形式的基底，其至少一部分是纤维素，其经过化学修饰以将纤维素部分中的羟基转化为离子吸附位点。 生物学或生物活性剂的离子形式，即抗菌剂，抗真菌剂，止痛剂，组织治疗剂，局部麻醉剂，可溶解剂，酶或血管收缩剂被吸附在该底物 。 离子键将该试剂暂时保持在与基材接触的渗出物的量的基质上以便控制释放。 通过在室温下将该试剂吸附在该基材上形成离子键。 与身体渗出物中的离子交换离子交换施加伤口敷料的伤口接触时，离子键解离，从而以与与底物接触的渗出物的量成比例的量释放该试剂。

公开(公告)号：US5910423A

公开(公告)日：1999-06-08

申请号：US430834

申请日：1995-04-28

申请人： Hiroshi Yamazaki ,  Kouchi Matsumoto

发明人： Hiroshi Yamazaki ,  Kouchi Matsumoto

IPC分类号： C12Q1/28 ,  C12Q1/00

CPC分类号： C12Q1/28 ,  C12Q2326/12

摘要： A method is provided for making a water soluble powdered formulation including a water-insoluble or difficultly-water-soluble chromogenic agent therein. The method includes first melting a water-soluble or water-miscible, heat-stable, polymeric material, e.g., PEG. The water-insoluble or difficultly-water-soluble chromogenic agent is then dissolved in such molten polymeric material. The molten polymeric material and the dissolved chromogenic agent are heated together for a predetermined period of time to provide a molten homogenate. The molten homogenate is then cooled to its solidification temperature to provide a solid homogenate. Finally, the cooled solid homogenate is pulverized to powdered form.

摘要翻译： 提供了一种制备包含其中不溶于水或难溶于水的发色剂的水溶性粉末制剂的方法。 该方法包括首先熔融水溶性或水混溶性，热稳定的聚合材料，例如PEG。 然后将水不溶性或难溶于水的显色剂溶解在这种熔融聚合物材料中。 将熔融的聚合物材料和溶解的显色剂一起加热预定的时间以提供熔融匀浆。 然后将熔融匀浆冷却至其固化温度以提供固体匀浆。 最后将冷却的固体匀浆粉碎成粉末状。

公开(公告)号：US4613377A

公开(公告)日：1986-09-23

申请号：US674136

申请日：1984-11-23

申请人： Hiroshi Yamazaki ,  Kouchi Matsumoto

发明人： Hiroshi Yamazaki ,  Kouchi Matsumoto

IPC分类号： C13K11/00 ,  C13D3/14

CPC分类号： C13K11/00

摘要： Novel, highly useful, sweet fructose-containing syrups also containing fructooligosaccharides are provided herein by the partial or substantially complete hydrolysis of inulin. The process includes first providing an aqueous solution containing inulin from Jerusalem artichoke tubers or chicory roots. Then the warm aqueous solution of inulin is passed through a column containing a strong acid cation-exchange resin, thereby providing an effluent having a pH of about 2.0-about 3.0. The effluent is then hydrolyzed by heating at a temperature of about 70.degree.-about 100.degree. C., and the hydrolyzate is passed through a column containing of about 6.5-about 7.0. resin, thereby providing an effluent having a pH about 6.5-about 7.0. Optionally, after the hydrolysis step, the hydrolyzate is decolorized by contact with activated or granular charcoal. The effluent is then concentrated to a syrup containing less water than the effluent, e.g. one containing about 40-about 70% solids. The sweet fructose syrup containing oligofructans can be used as truly "health" sweetener, particularly ideal for elderly people and diabetics. The pulp obtained after the juice extraction is rich in protein and can be used as feed.

摘要翻译： 本文通过部分或基本上完全水解菊粉提供了含有低聚果糖的新颖的，非常有用的甜果糖糖浆。 该方法首先提供从菊芋块茎或菊苣根中含有菊粉的水溶液。 然后将温暖的菊糖水溶液通过含有强酸阳离子交换树脂的柱，从而提供pH为约2.0〜约3.0的流出物。 然后通过在约70℃ - 100℃的温度下加热将流出物水解，并使水解产物通过含有约6.5-约7.0的柱。 从而提供pH约6.5-7.0的流出物。 任选地，在水解步骤之后，水解产物通过与活性或颗粒状炭接触脱色。 然后将流出物浓缩成含有比流出物少的水的糖浆，例如水。 一个含约40-约70％的固体。 含有低聚果糖的甜果糖可用作真正的“健康”甜味剂，特别适用于老年人和糖尿病患者。 果汁提取后获得的纸浆富含蛋白质，可用作饲料。