公开(公告)号：US20240360495A1

公开(公告)日：2024-10-31

申请号：US18639734

申请日：2024-04-18

Applicant: Agilent Technologies, Inc.

Inventor： Jesper Lohse ,  Mike Paw Maischnack Hansen

IPC: C12Q1/6841 ,  C07D311/82 ,  C07D311/90 ,  C07D493/10 ,  C12N9/08 ,  C12N9/96 ,  C12Q1/28 ,  G01N33/58

CPC classification number: C12Q1/6841 ,  C07D311/82 ,  C07D311/90 ,  C07D493/10 ,  C12N9/0065 ,  C12N9/96 ,  C12Q1/28 ,  G01N33/581

Abstract: Chromogenic conjugates for color-based detection of targets are described. The conjugates comprise a chromogenic moiety such as a rhodamine, rhodol or fluorescein. The chromogenic moiety is linked to a peroxidase substrate. The chromogenic conjugates can be used in immunohistochemical analysis and in situ hybridization. The conjugates can be used to detect 1, 2, 3 or more targets in a sample by color.

公开(公告)号：US12049566B2

公开(公告)日：2024-07-30

申请号：US16320343

申请日：2017-07-28

Applicant: HITACHI CHEMICAL DIAGNOSTICS SYSTEMS CO., LTD.

Inventor： Haruyo Soya ,  Yuki Katayama

IPC: C09B67/14 ,  C09B21/00 ,  C09B67/00 ,  C09B67/44 ,  C12Q1/28

CPC classification number: C09B67/0017 ,  C09B21/00 ,  C09B67/00 ,  C09B67/0083 ,  C12Q1/28

Abstract: The present invention provides a method for preserving a leuco chromogen-containing aqueous solution comprising: adding at least one acid compound selected from the group consisting of a phosphoric acid compound, a carboxylic acid compound, a sulfonic acid compound, and a sulfuric acid compound to a leuco chromogen-containing aqueous solution; a method for stabilizing a leuco chromogen in an aqueous solution comprising: adding at least one acid compound selected from the group consisting of a phosphoric acid compound, a carboxylic acid compound, a sulfonic acid compound, and a sulfuric acid compound to a leuco chromogen-containing aqueous solution; and a liquid reagent comprising a leuco chromogen and at least one acid compound selected from the group consisting of a phosphoric acid compound, a carboxylic acid compound, a sulfonic acid compound, and a sulfuric acid compound.

公开(公告)号：US11993810B2

公开(公告)日：2024-05-28

申请号：US17885188

申请日：2022-08-10

Applicant: Agilent Technologies, Inc.

Inventor： Jesper Lohse ,  Mike Paw Maischnack Hansen

IPC: C12Q1/68 ,  C07D311/82 ,  C07D311/90 ,  C07D493/10 ,  C12N9/08 ,  C12N9/96 ,  C12Q1/28 ,  C12Q1/6841 ,  G01N33/58

CPC classification number: C12Q1/6841 ,  C07D311/82 ,  C07D311/90 ,  C07D493/10 ,  C12N9/0065 ,  C12N9/96 ,  C12Q1/28 ,  G01N33/581

Abstract: Chromogenic conjugates for color-based detection of targets are described. The conjugates comprise a chromogenic moiety such as a rhodamine, rhodol or fluorescein. The chromogenic moiety is linked to a peroxidase substrate. The chromogenic conjugates can be used in immunohistochemical analysis and in situ hybridization. The conjugates can be used to detect 1, 2, 3 or more targets in a sample by color.

公开(公告)号：US20240117407A1

公开(公告)日：2024-04-11

申请号：US18306710

申请日：2023-04-25

Applicant: Concert Pharmaceuticals, Inc.

Inventor： Roger Tung

IPC: C12Q1/28 ,  A61K31/195 ,  A61K31/4709 ,  A61K31/485 ,  A61K31/49 ,  C07B59/00 ,  C07D221/28 ,  C07D471/08 ,  G01N33/49 ,  G01N33/493

CPC classification number: C12Q1/28 ,  A61K31/195 ,  A61K31/4709 ,  A61K31/485 ,  A61K31/49 ,  C07B59/002 ,  C07D221/28 ,  C07D471/08 ,  G01N33/491 ,  G01N33/493

Abstract: This disclosure relates to novel morphinan compounds and their derivatives, pharmaceutically acceptable salts, solvates, and hydrates thereof. This disclosure also provides compositions comprising a compound of this disclosure and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering a σ1 receptor agonist that also has NMDA antagonist activity.

公开(公告)号：US11921050B2

公开(公告)日：2024-03-05

申请号：US17205491

申请日：2021-03-18

Applicant: Johnson & Johnson Consumer Inc.

Inventor： Curt Binner ,  Justin Mellinger ,  Alexandru Paunescu

IPC: G01N21/78 ,  A61F13/42 ,  A61F13/49 ,  B01L3/00 ,  C12Q1/26 ,  C12Q1/28 ,  C12Q1/54 ,  G01N21/31 ,  G01N33/493 ,  G01N33/52 ,  G01N21/77

CPC classification number: G01N21/78 ,  A61F13/42 ,  A61F13/49 ,  B01L3/502707 ,  B01L3/502761 ,  B01L3/502776 ,  C12Q1/26 ,  C12Q1/28 ,  C12Q1/54 ,  G01N21/31 ,  G01N33/493 ,  G01N33/52 ,  B01L2200/10 ,  G01N2021/7756 ,  G01N2021/7766 ,  G01N2201/062

Abstract: A method for predicting risk of a future disease condition includes the steps of collecting and transporting bodily fluid to at least one colorimetric analyte sensing element, detecting the presence of bodily fluid, collecting optical data relating to the at least one colorimetric analyte sensing element with at least one spectrophotometer after a predetermined time period after detecting the presence of bodily fluid in contact with the colorimetric analyte sensing element, communicating the optical data to a computing system having at least one processor and data storage, analyzing the optical data to determine at least one analyte concentration in the bodily fluid, identifying a threshold analyte concentration of the at least one analyte in the bodily fluid that is an indicator of the risk of developing a future disease condition; and recording the at least one analyte concentration in the bodily fluid over time.

公开(公告)号：US20230243857A1

公开(公告)日：2023-08-03

申请号：US18007690

申请日：2021-06-02

Applicant: DENKA COMPANY LIMITED

Inventor： Yasuki ITOH

IPC: G01N33/92 ,  C12Q1/60 ,  C12Q1/44 ,  C12Q1/28 ,  C12N9/04 ,  C12N9/18

CPC classification number: G01N33/92 ,  C12Q1/60 ,  C12Q1/44 ,  C12Q1/28 ,  C12N9/0006 ,  C12N9/18 ,  C12Y101/03006 ,  C12Y301/01013

Abstract: There is provided a kit that is used for fractionation of cholesterol (lipoprotein C) in a lipoprotein other than small dense LDL in a sample, the kit containing a first reagent composition having at least one activity selected from the group consisting of a cholesterol esterase activity and a cholesterol oxidase activity and a second reagent composition for quantifying the lipoprotein C of a measurement target, where a ratio R1 represented by ABS400/ABS450 is 0.90 or more and 3.50 or less, and in an absorption spectrum after storing the second reagent composition at 37° C. for two weeks, the ratio R1 represented by ABS400/ABS450 is 0.90 or more and 9.00 or less.

公开(公告)号：US11667948B2

公开(公告)日：2023-06-06

申请号：US16275853

申请日：2019-02-14

Applicant: Case Western Reserve University

Inventor： Alexander Rodriguez-Palacios ,  Fabio Cominelli

IPC: C12Q1/28 ,  C12Q1/10 ,  G01N21/78 ,  G01N33/52

CPC classification number: C12Q1/28 ,  C12Q1/10 ,  G01N21/78 ,  G01N33/52 ,  C12Y111/02002

Abstract: One aspect of the present disclosure can include a method for reducing or alleviating inflammation in the digestive tract of a subject in need thereof that consumes a disruptive dietary component. One step of the method can include assaying a previously obtained fecal sample from the subject for the presence of one or more Proteobacteria and an activity level of a peroxidase enzyme. The subject can decrease ingestion of the disruptive dietary component if the assayed presence of the one or more Proteobacteria and the activity level of the peroxidase enzyme are increased as compared to control levels.

公开(公告)号：US20180201970A1

公开(公告)日：2018-07-19

申请号：US15742282

申请日：2016-04-19

Applicant: BIOLAN MICROBIOSENSORES, S.L.

Inventor： Roberto GONZALEZ RIOJA ,  Sonia MAZA DEL RIO ,  Sandra SALLERES ALONSO ,  Arrate JAUREGUIBEITIA CAYROLS ,  Irune GONZALEZ URQUIDI ,  Alai ARANTZAMENDI EGIGUREN

IPC: C12Q1/00 ,  C12Q1/28 ,  G01N27/327 ,  C12M1/34 ,  G01N33/02 ,  C12M1/40 ,  C12N9/08

CPC classification number: C12Q1/005 ,  C12M1/34 ,  C12M1/40 ,  C12N9/0065 ,  C12Q1/004 ,  C12Q1/26 ,  C12Q1/28 ,  G01N27/327 ,  G01N27/3271 ,  G01N33/02

Abstract: A system for measuring sulphite in food samples is provided using a biosensor, a method for determining sulphite in food samples using the biosensor, and the biosensor for measuring the sulphite values in food samples. The system uses an amperometric biosensor having a bi-enzymatic system, a working electrode, a counter electrode and a reference electrode. The bi-enzymatic system has the human sulphite oxidase and peroxidase enzymes, and the immobilisation of the enzymes in the working electrode is carried out via simple physical retention. The mixture of the enzymes is mixed with a chemical mediator by applying a sample to the amperometric biosensor; changing the electrical current upon coming into contact with the analyte to be detected; and amperometrically measuring said electrical current in solutions with continuous agitation, using a constant potential.

公开(公告)号：US09958449B2

公开(公告)日：2018-05-01

申请号：US15166133

申请日：2016-05-26

Applicant: Dako Denmark A/S

Inventor： Jesper Lohse ,  Galina Skladchikova

IPC: C12Q1/26 ,  C12Q1/28 ,  G01N33/58 ,  G01N33/574

CPC classification number: G01N33/581 ,  C12Q1/26 ,  C12Q1/28 ,  G01N33/57492

Abstract: The present invention relates to methods and compounds for enzyme-mediated amplification of target-associated signals for visualization of biological or chemical targets in samples, wherein the targets are immobilized, in particular the invention relates to the oxidoreductase-mediated signal amplification for visualization of targets in samples comprising cells. The methods of the invention are particular useful for qualitative and quantitative evaluation of biological markers relating to medical diagnostic and therapy.

公开(公告)号：US20180106727A1

公开(公告)日：2018-04-19

申请号：US15845702

申请日：2017-12-18

Applicant: Etsuro ITO ,  Satoshi WATABE ,  Toshiaki MIURA ,  Teruki YOSHIMURA

Inventor： Etsuro ITO

IPC: G01N21/78 ,  G01N21/25 ,  C12Q1/00 ,  C12Q1/34 ,  C12Q1/42 ,  C12Q1/28

CPC classification number: G01N21/78 ,  C12Q1/008 ,  C12Q1/28 ,  C12Q1/34 ,  C12Q1/42 ,  G01N21/25 ,  G01N2333/90209 ,  G01N2333/916 ,  G01N2333/924

Abstract: Provided is a ultra-high-sensitivity assay in which the assay can be made on a commonly used assay apparatus such as an absorptiometer and a plate reader or with naked eyes. The high-sensitivity assay in which the assay can be made on a commonly used assay apparatus or with naked eyes can be provided by combining an enzyme cycling method using thio-NAD(P) as a coenzyme, a labeling enzyme and a substrate for the labeling enzyme optimally, and by amplifying thio-NAD(P)H, which is a signaling substance, exponentially and then quantifying the thio-NAD(P)H colorimetrically.