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6 条记录 (耗时 0.028 秒)

    Cephem compounds
    2.
    发明授权
    Cephem compounds 失效
    头孢烯化合物

    公开(公告)号：US4705784A

    公开(公告)日：1987-11-10

    申请号：US682283

    申请日：1984-12-17

    申请人： Hirotada Yamada ,  Naruhito Masai ,  Sinji Ueda ,  Takao Okuda ,  Masatomo Fukasawa ,  Masuhiro Kato ,  Masataka Fukumura

    发明人： Hirotada Yamada ,  Naruhito Masai ,  Sinji Ueda ,  Takao Okuda ,  Masatomo Fukasawa ,  Masuhiro Kato ,  Masataka Fukumura

    IPC分类号： A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D501/34

    CPC分类号： A61K31/545

    摘要： A cephem compound represent by the general formula ##STR1## wherein, R.sup.1 represents hydrogen or lower alkyl, R.sup.2 and R.sup.3 are the same or different and each represents hydrogen or lower alkyl, R.sup.4 represents carboxyl or esterified carboxyl, and n represents 0 or 1, a salt of the cephem compound, and a process for producing the cephem compound or a salt thereof. Compounds of the above formula and salts thereof are valuable as antibacterial agents and are especially useful as oral drugs in the prevention or treatment of bacterial infectious diseases.

    摘要翻译： 头孢烯化合物由通式表示，其中R1表示氢或低级烷基，R2和R3相同或不同，各自表示氢或低级烷基，R4表示羧基或酯化羧基，n表示0或1， 头孢烯化合物的盐，以及头孢烯化合物或其盐的制备方法。 上述式的化合物及其盐作为抗菌剂是有价值的，并且特别可用作预防或治疗细菌感染性疾病的口服药物。

    Certain pyridyl-thiazolidin-4-one having anti-ulcer activity
    6.
    发明授权
    Certain pyridyl-thiazolidin-4-one having anti-ulcer activity 失效
    某些具有抗溃疡活性的吡啶基 - 噻唑烷-4-酮

    公开(公告)号：US5021435A

    公开(公告)日：1991-06-04

    申请号：US297313

    申请日：1989-01-17

    申请人： Naruhito Masai ,  Masao Enomoto ,  Atsuyuki Kojima ,  Hiroaki Masumori ,  Nobuyuki Hara ,  Youichi Hara ,  Shigeaki Morooka

    发明人： Naruhito Masai ,  Masao Enomoto ,  Atsuyuki Kojima ,  Hiroaki Masumori ,  Nobuyuki Hara ,  Youichi Hara ,  Shigeaki Morooka

    IPC分类号： A61K31/44 ,  A61P1/04 ,  C07D417/04

    CPC分类号： C07D417/04

    摘要： A 2-pyridyl-thiazolidin-4-one derivative represented by the formula: ##STR1## wherein R.sub.1 and R.sub.2 are each a hydrogen atom, an C.sub.1 -C.sub.20 alkyl group, an C.sub.2 -C.sub.20 alkenyl group, an C.sub.2 -C.sub.20 alkynyl group, an aryl group, a C.sub.3 -C.sub.8 cycloalkyl group or an aralkyl group which may have a substituent, R.sub.3 is a hydrogen atom, an C.sub.1 -C.sub.20 alkyl group, an C.sub.2 -C.sub.20 alkenyl group, an C.sub.2 -C.sub.20 alkynyl group, a C.sub.3 -C.sub.8 cycloalkyl group or an aralkyl group which may have a substituent, P is a pyridyl group or its N-substituted pyridinium salt which may have a substituent, said substituent being selected from the group consisting of halogen atom, cyano group, hydroxy group, amino group, lower alkyl group, lower alkoxy group, lower alkylamino group, halogenated lower alkyl group, acyl group, acyloxy group, acylthio group, acylamino group, carboxyl group, lower alkoxycarbonyl group, carbamoyl group, lower alkyl substituted carbamoyl group, heterocyclic group, and lower cycloalkyl group, and n represents an integer of 0, 1 or 2, or a pharmaceutically acceptable salts thereof and an anti-ulcer agent which contains, as an effective ingredient, said 2-pyridyl-thiazolidine-4-one derivative or a pharmaceutically acceptable salt thereof.