公开(公告)号：US08889649B2

公开(公告)日：2014-11-18

申请号：US13884436

申请日：2011-11-10

申请人： Koichi Nakashiro ,  Hiroyuki Hamakawa ,  Hiroshi Tanaka

发明人： Koichi Nakashiro ,  Hiroyuki Hamakawa ,  Hiroshi Tanaka

IPC分类号： C12N15/11 ,  C12Q1/68 ,  A61K31/7088 ,  C12N15/113 ,  A61K48/00

CPC分类号： C12N15/113 ,  A61K31/7088 ,  A61K48/00 ,  C12N2310/113 ,  C12N2310/141 ,  C12N2310/3231 ,  C12N2320/11 ,  C12N2330/31

摘要： Provided is a composition that contains an antisense oligonucleotide to a micro RNA and is capable of inhibiting the growth of cancer cells. The present invention, as one aspect, relates to a composition for suppressing the growth of human cancer cells, the composition containing an antisense oligonucleotide to a micro RNA, wherein the micro RNA is selected from the group consisting of hsa-miR-133a, hsa-miR-133b, hsa-miR-346 and hsa-miR-361-3p. The present invention, as another aspect, relates to a composition for suppressing the growth of human head/neck cancer cells, the composition containing an antisense oligonucleotide to a micro RNA, wherein the micro RNA is selected from the group consisting of hsa-miR-92a, hsa-miR-133a, hsa-miR-133b, hsa-miR-139-5p, hsa-miR-197, hsa-miR-328, hsa-miR-346, hsa-miR-361-3p, hsa-miR-605, hsa-miR-766, hsa-miR-1228, hsa-miR-1252, hsa-miR-1260 and hsa-miR-1271.

摘要翻译： 本发明提供了含有对微RNA的反义寡核苷酸并且能够抑制癌细胞生长的组合物。 本发明一方面涉及抑制人癌细胞生长的组合物，该组合物含有对微RNA的反义寡核苷酸，其中所述微RNA选自hsa-miR-133a，hsa -miR-133b，hsa-miR-346和hsa-miR-361-3p。 本发明另一方面涉及抑制人头颈部癌细胞生长的组合物，该组合物含有对微RNA的反义寡核苷酸，其中微RNA选自hsa-miR- 92a，hsa-miR-133a，hsa-miR-133b，hsa-miR-139-5p，hsa-miR-197，hsa-miR-328，hsa-miR-346，hsa-miR-361-3p， miR-605，hsa-miR-766，hsa-miR-1228，hsa-miR-1252，hsa-miR-1260和hsa-miR-1271。

公开(公告)号：US08750765B2

公开(公告)日：2014-06-10

申请号：US12967336

申请日：2010-12-14

申请人： Akihiro Watanabe ,  Hiroyuki Hamakawa ,  Hiroshi Yamazaki

发明人： Akihiro Watanabe ,  Hiroyuki Hamakawa ,  Hiroshi Yamazaki

IPC分类号： G03G15/08

CPC分类号： G03G15/0839 ,  G03G15/0844 ,  G03G15/0877 ,  G03G15/0893 ,  G03G2215/0822 ,  G03G2215/083 ,  G03G2215/0833

摘要： Provided is a developing device including: a developing container including a developer replenishing port from which the developer is replenished, and a developer discharge port which is provided on a downstream side of one of the conveyance paths and from which surplus developer is discharged; and a discharge regulating portion provided to one of the plurality of stirring members which is arranged in the one of the conveyance paths, in which the discharge regulating portion includes a regulating member arranged so as to face the developer discharge port, for regulating movement of the developer to the developer discharge port side, and a decelerating conveyance member arranged between the helical blade and the regulating member, for partially reducing a conveying speed of the developer in the one of the conveyance paths.

摘要翻译： 提供了一种显影装置，包括：显影剂容器，其包括显影剂补充口，补充显影剂的显影剂;以及显影剂排出口，其设置在输送路径中的一个输送路径的下游侧，剩余的显影剂被排出; 以及设置在所述多个搅拌部件中的一个设置在所述输送路径中的一个的排出调节部，所述排出限制部包括配置成朝向所述显影剂排出口的调节部件， 显影剂到显影剂排出口侧，以及设置在螺旋叶片和调节构件之间的减速输送构件，用于部分地降低一个输送路径中的显影剂的输送速度。

公开(公告)号：US08190071B2

公开(公告)日：2012-05-29

申请号：US12149744

申请日：2008-05-07

申请人： Hiroyuki Hamakawa

发明人： Hiroyuki Hamakawa

IPC分类号： G03G15/09

CPC分类号： G03G15/09 ,  G03G2215/0861

摘要： The surface of a developing roller is coated with a phenol resin layer at a higher level in triboelectric series than a toner. A positively charged toner supplied from a magnetic roller onto the developing roller is negatively charged by friction with the phenol resin layer at the higher level in the triboelectric series. As a result, the positive charge of the toner is cancelled out, and the charge amount of toner per unit weight on the developing roller (Q/M)s decreases. Applying this principle, relationship between (Q/M)s and the charge amount of toner per unit weight on the magnetic roller (Q/M)m satisfies (Q/M)s

摘要翻译： 显影辊的表面以比调色剂更高水平的酚醛树脂层涂覆摩擦系列。 从磁性辊供给到显影辊上的带正电的调色剂通过与摩擦系列中较高级别的酚醛树脂层的摩擦而带负电荷。 结果，调色剂的正电荷被抵消，并且显影辊上的每单位重量的调色剂的电荷量（Q / M）减小。 应用该原理，（Q / M）s与磁性辊上的每单位重量的调色剂的电荷量（Q / M）m的关系满足（Q / M）s <（Q / M）m。

公开(公告)号：US20090154962A1

公开(公告)日：2009-06-18

申请号：US12331692

申请日：2008-12-10

申请人： Asami Kotera ,  Hiroyuki Hamakawa ,  Akihiro Watanabe ,  Masashi Fujishima ,  Hiroshi Yamazaki ,  Sayo Uemura

发明人： Asami Kotera ,  Hiroyuki Hamakawa ,  Akihiro Watanabe ,  Masashi Fujishima ,  Hiroshi Yamazaki ,  Sayo Uemura

IPC分类号： G03G15/09

CPC分类号： G03G15/0928 ,  G03G2215/0861

摘要： A developing device visualizing an electrostatic latent image previously formed on the surface of an image carrier as toner image, comprising: a developing roller placed at a position facing the image carrier, carrying a toner on the surface thereof, conveying the toner and flying the conveyed toner onto the surface of the image carrier; and a resin layer coated on the surface of the developing roller, wherein the absolute value of the difference in charge between the toners in the upper and lower layers of the toner layer formed on the developing roller as the toner carried on the developing roller is 6 μC/g or less.

摘要翻译： 一种将预先形成在图像载体的表面上的静电潜像可视化的显影装置作为调色剂图像，包括：显影辊，其设置在面向图像载体的位置，在其表面上承载调色剂，输送调色剂并使传送的 调色剂到图像载体的表面上; 以及涂覆在显影辊表面上的树脂层，其中在显影辊上承载的调色剂上形成在显影辊上的调色剂层的上层和下层中的调色剂之间的电荷差绝对值为6 muC / g以下。

公开(公告)号：US07421226B2

公开(公告)日：2008-09-02

申请号：US11416339

申请日：2006-05-02

申请人： Koji Suenami ,  Eiji Nimura ,  Hirohisa Endou ,  Hiroyuki Hamakawa ,  Yoshihiro Yamagishi

发明人： Koji Suenami ,  Eiji Nimura ,  Hirohisa Endou ,  Hiroyuki Hamakawa ,  Yoshihiro Yamagishi

IPC分类号： G03G15/08

CPC分类号： G03G15/0942 ,  G03G2215/0609 ,  G03G2215/0634

摘要： A developing device (50) includes a developing sleeve (53) for supplying toner particles (T) to a latent image area (22) on a peripheral surface of a photoconductive drum (20) while rotating about a central shaft (534). The developing sleeve (53) has an immovable sleeve magnet (533) therein. Two magnetic members (82) are disposed in opposite end portions of the developing sleeve (53) and are spaced a predetermined distance from the peripheral surface of the developing sleeve. Each magnet member (82) has an arc shape. A magnetic member magnet (83) is mounted in the magnet member (82) and faces a sleeve magnet (533) so that opposite facing portions of the magnetic member magnet (83) and the sleeve magnet (533) have the same polarity. With this construction, toner particles are prevented from leaking from the end portions of the developing sleeve (53).

摘要翻译： 显影装置（50）包括用于在绕中心轴（534）旋转的同时将调色剂颗粒（T）供应到感光鼓（20）的外周表面上的潜像区域（22）的显影套筒（53）。 显影套筒（53）中具有不可移动的套筒磁体（533）。 两个磁性构件（82）设置在显影套筒（53）的相对端部，并且与显影套筒的外围表面隔开预定的距离。 每个磁体构件（82）具有弧形。 磁性构件磁体（83）安装在磁体构件（82）中并且面向套筒磁体（533），使得磁性构件磁体（83）和套筒磁体（533）的相对的相对部分具有相同的极性。 利用这种结构，防止调色剂颗粒从显影套筒（53）的端部泄漏。

公开(公告)号：US20120270218A1

公开(公告)日：2012-10-25

申请号：US13518656

申请日：2010-12-22

申请人： Koichi Nakashiro ,  Hiroyuki Hamakawa ,  Hiroyuki Goda

发明人： Koichi Nakashiro ,  Hiroyuki Hamakawa ,  Hiroyuki Goda

IPC分类号： C12Q1/68 ,  C07H21/04 ,  G01N21/64

CPC分类号： C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/158

摘要： Provided are a method for analyzing metastasis of head and neck cancer to a cervical lymph node, and a tumor marker for head and neck cancer used therein. Specifically, provided is a method for analyzing metastasis of head and neck cancer to a cervical lymph node, involving: measuring an expression level of at least one gene selected from the group consisting of genes represented by SEQ ID NOS: 1 to 36 in the sequence listing in a cervical lymph node sample; and comparing the aforementioned expression level with a reference value. Also provided is a tumor marker for head and neck cancer used in the aforementioned method for analyzing cervical lymph node metastasis, including at least one gene selected from the group consisting of genes represented by SEQ ID NOS: 1 to 36 in the sequence listing, and/or an expression product of the aforementioned gene and/or an expression level thereof.

摘要翻译： 本发明提供了一种分析头颈癌与宫颈淋巴结转移的方法，以及其中使用的头颈癌的肿瘤标志物。 具体而言，提供了一种分析头颈癌与颈淋巴结转移的方法，其特征在于：测定序列号1〜36所示的基因中至少一种选自下组的基因的表达量： 列在颈部淋巴结样本中; 并将上述表达水平与参考值进行比较。 还提供了上述用于分析颈淋巴结转移的方法中的头颈癌的肿瘤标记物，包括选自序列表中SEQ ID NO：1〜36所示基因的至少一种基因，以及 /或上述基因的表达产物和/或其表达水平。

公开(公告)号：US20090311012A1

公开(公告)日：2009-12-17

申请号：US12405446

申请日：2009-03-17

申请人： Sayo Mabuchi ,  Hiroyuki Hamakawa ,  Akihiro Watanabe ,  Masashi Fujishima ,  Hiroshi Yamazaki ,  Asami Kotera

发明人： Sayo Mabuchi ,  Hiroyuki Hamakawa ,  Akihiro Watanabe ,  Masashi Fujishima ,  Hiroshi Yamazaki ,  Asami Kotera

IPC分类号： G03G15/08

CPC分类号： G03G15/0818 ,  G03G2215/0861

摘要： This invention relates to a developing device 18 for use in an image-forming apparatus comprising a developing roller 100 having a conductive base surface 19 which may be covered with a resin layer 17 layer comprising an ion conductive material and a silicone-modified urethane resin having an ether structure.

摘要翻译： 本发明涉及一种用于图像形成装置的显影装置18，其包括具有导电基底表面19的显影辊100，该导电基底表面19可以被包含离子导电材料的树脂层17层和具有硅氧烷改性的聚氨酯树脂 醚结构。

公开(公告)号：US20090185831A1

公开(公告)日：2009-07-23

申请号：US12352183

申请日：2009-01-12

申请人： Asami Kotera ,  Hiroyuki Hamakawa

发明人： Asami Kotera ,  Hiroyuki Hamakawa

IPC分类号： G03G15/08

CPC分类号： G03G15/0812 ,  G03G15/0815 ,  G03G2215/0802

摘要： A developing device is provided with a developing roller arranged to face a photoconductor for forming an electrostatic latent image and adapted to supply a toner to the photoconductor, an agitating member for agitating a developer, a supply roller that holds the developer agitated by the agitating member, and supplies the toner to an area facing the developing roller; a restricting member for blocking the developer supplied onto the supply roller and restricting the amount of the developer conveyed by the supply roller, and an intermediate roller including a first magnetic pole facing in a direction toward the staying developer by being restricted by the restricting member for attracting the staying developer and arranged at such a position as to face the developer blocked by the restricting member. Thus, the developing device can avoid image quality deterioration even when a developing process continues over a long period of time.

摘要翻译： 显影装置设置有显影辊，其布置成面对用于形成静电潜像并用于向感光体供应调色剂的感光体，用于搅拌显影剂的搅拌构件，保持由搅拌构件搅动的显影剂的供给辊 并将调色剂供给到面向显影辊的区域; 限制构件，用于阻止供应辊上供应的显影剂，并限制由供给辊输送的显影剂的量;以及中间辊，其包括第一磁极，该第一磁极被限制构件限制在朝向停留显影剂的方向上 吸引保持显影剂并且布置在面对被限制构件阻挡的显影剂的位置。 因此，即使显影处理持续长时间，显影装置也可以避免图像质量劣化。

公开(公告)号：US07421227B2

公开(公告)日：2008-09-02

申请号：US11434852

申请日：2006-05-16

申请人： Hiroyuki Hamakawa ,  Takaaki Kamei ,  Yoshihiro Yamagishi ,  Koji Suenami ,  Hirohisa Endou

发明人： Hiroyuki Hamakawa ,  Takaaki Kamei ,  Yoshihiro Yamagishi ,  Koji Suenami ,  Hirohisa Endou

IPC分类号： G03G15/08

CPC分类号： G03G15/0942

摘要： A developing device includes a developing sleeve for supplying toner particles to a latent image area on a peripheral surface of a photoconductive drum while rotating about an axis. The developing sleeve has a permanent magnet therein. Two magnetic members are provided in the developing device and face opposite ends of a peripheral surface of the developing sleeve at a predetermined distance from the developing sleeve. The magnetic members have arc-shaped inner surfaces. A blade is spaced a predetermined distance from a central portion of the peripheral surface of the developing sleeve. The blade adjusts the amount of toner particles supplied to the photoconductive drum. The gap between the arc-shaped inner surface of the magnetic member and the peripheral surface of the developing sleeve gradually increases from upstream to downstream in a rotational direction of the developing sleeve.

摘要翻译： 显影装置包括显影套筒，用于在绕轴线旋转的同时将调色剂颗粒供应到感光鼓的外周表面上的潜像区域。 显影套筒中具有永磁体。 在显影装置中设置有两个磁性构件，并且与显影套筒相隔一预定距离的两个磁性构件面对显影套筒的周面的相对端。 磁性构件具有弧形内表面。 叶片与显影套筒的外围表面的中心部分隔开预定的距离。 刀片调节供应到感光鼓的调色剂颗粒的量。 磁性构件的弧形内表面与显影套筒的周面之间的间隙在显影套筒的旋转方向上从上游到下游逐渐增加。

公开(公告)号：US20070086801A1

公开(公告)日：2007-04-19

申请号：US11546892

申请日：2006-10-13

申请人： Shingo Sakato ,  Ai Takagami ,  Eiji Nimura ,  Hiroyuki Hamakawa ,  Yoshinori Horiuchi ,  Masashi Fujishima

发明人： Shingo Sakato ,  Ai Takagami ,  Eiji Nimura ,  Hiroyuki Hamakawa ,  Yoshinori Horiuchi ,  Masashi Fujishima

IPC分类号： G03G15/02 ,  G03G15/06

CPC分类号： G03G15/5037 ,  G03G2215/00054

摘要： In an image forming apparatus, a control section 41 adjusts the surface potential of a photoconductor or the developing potential of a developer carrying member based on the detection result of a surface potential sensor 44, and performs first correction whereby, relative to the reference value of the applied bias of a charger 2 or the developing bias of the developer carrying member in a developing unit 4 as observed during potential adjustment, the applied bias or the developing bias is varied so as to keep constant the potential difference between the surface potential of the photoconductor and the developing potential of the developer carrying member during image formation. The control section also performs second correction whereby the applied bias or the developing bias is restored to the reference value over a predetermined period after the completion of continuous image formation.

摘要翻译： 在图像形成装置中，控制部41基于表面电位传感器44的检测结果来调整感光体的表面电位或显影剂承载部件的显影电位，并进行第一校正，由此相对于 充电器2的施加偏压或显影单元4中的显影剂承载构件的显影偏压，如在电位调节期间所观察到的，所施加的偏压或显影偏压被改变，以便保持恒定的表面电位 感光体和图像形成期间显影剂承载构件的显影电位。 控制部分还执行第二校正，由此在连续图像形成完成之后的预定时间段内施加的偏压或显影偏压恢复到参考值。