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公开(公告)号：US08889649B2
公开(公告)日：2014-11-18
申请号：US13884436
申请日：2011-11-10
IPC分类号： C12N15/11 , C12Q1/68 , A61K31/7088 , C12N15/113 , A61K48/00
CPC分类号： C12N15/113 , A61K31/7088 , A61K48/00 , C12N2310/113 , C12N2310/141 , C12N2310/3231 , C12N2320/11 , C12N2330/31
摘要： Provided is a composition that contains an antisense oligonucleotide to a micro RNA and is capable of inhibiting the growth of cancer cells. The present invention, as one aspect, relates to a composition for suppressing the growth of human cancer cells, the composition containing an antisense oligonucleotide to a micro RNA, wherein the micro RNA is selected from the group consisting of hsa-miR-133a, hsa-miR-133b, hsa-miR-346 and hsa-miR-361-3p. The present invention, as another aspect, relates to a composition for suppressing the growth of human head/neck cancer cells, the composition containing an antisense oligonucleotide to a micro RNA, wherein the micro RNA is selected from the group consisting of hsa-miR-92a, hsa-miR-133a, hsa-miR-133b, hsa-miR-139-5p, hsa-miR-197, hsa-miR-328, hsa-miR-346, hsa-miR-361-3p, hsa-miR-605, hsa-miR-766, hsa-miR-1228, hsa-miR-1252, hsa-miR-1260 and hsa-miR-1271.
摘要翻译： 本发明提供了含有对微RNA的反义寡核苷酸并且能够抑制癌细胞生长的组合物。 本发明一方面涉及抑制人癌细胞生长的组合物，该组合物含有对微RNA的反义寡核苷酸，其中所述微RNA选自hsa-miR-133a，hsa -miR-133b，hsa-miR-346和hsa-miR-361-3p。 本发明另一方面涉及抑制人头颈部癌细胞生长的组合物，该组合物含有对微RNA的反义寡核苷酸，其中微RNA选自hsa-miR- 92a，hsa-miR-133a，hsa-miR-133b，hsa-miR-139-5p，hsa-miR-197，hsa-miR-328，hsa-miR-346，hsa-miR-361-3p， miR-605，hsa-miR-766，hsa-miR-1228，hsa-miR-1252，hsa-miR-1260和hsa-miR-1271。
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公开(公告)号：US20140045917A1
公开(公告)日：2014-02-13
申请号：US13884436
申请日：2011-11-10
IPC分类号： C12N15/113
CPC分类号： C12N15/113 , A61K31/7088 , A61K48/00 , C12N2310/113 , C12N2310/141 , C12N2310/3231 , C12N2320/11 , C12N2330/31
摘要： Provided is a composition that contains an antisense oligonucleotide to a micro RNA and is capable of inhibiting the growth of cancer cells. The present invention, as one aspect, relates to a composition for suppressing the growth of human cancer cells, the composition containing an antisense oligonucleotide to a micro RNA, wherein the micro RNA is selected from the group consisting of hsa-miR-133a, hsa-miR-133b, hsa-miR-346 and hsa-miR-361-3p. The present invention, as another aspect, relates to a composition for suppressing the growth of human head/neck cancer cells, the composition containing an antisense oligonucleotide to a micro RNA, wherein the micro RNA is selected from the group consisting of hsa-miR-92a, hsa-miR-133a, hsa-miR-133b, hsa-miR-139-5p, hsa-miR-197, hsa-miR-328, hsa-miR-346, hsa-miR-361-3p, hsa-miR-605, hsa-miR-766, hsa-miR-1228, hsa-miR-1252, hsa-miR-1260 and hsa-miR-1271.
摘要翻译： 本发明提供了含有对微RNA的反义寡核苷酸并且能够抑制癌细胞生长的组合物。 本发明一方面涉及抑制人癌细胞生长的组合物，该组合物含有对微RNA的反义寡核苷酸，其中所述微RNA选自hsa-miR-133a，hsa -miR-133b，hsa-miR-346和hsa-miR-361-3p。 本发明另一方面涉及抑制人头颈部癌细胞生长的组合物，该组合物含有对微RNA的反义寡核苷酸，其中微RNA选自hsa-miR- 92a，hsa-miR-133a，hsa-miR-133b，hsa-miR-139-5p，hsa-miR-197，hsa-miR-328，hsa-miR-346，hsa-miR-361-3p， miR-605，hsa-miR-766，hsa-miR-1228，hsa-miR-1252，hsa-miR-1260和hsa-miR-1271。
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3.发明授权Method for analyzing cervical lymph node metastasis, and tumor marker for head and neck cancer 失效分析颈淋巴结转移的方法和头颈癌的肿瘤标志物公开(公告)号：US08715931B2
公开(公告)日：2014-05-06
申请号：US13518656
申请日：2010-12-22
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/158
摘要： Provided are a method for analyzing metastasis of head and neck cancer to a cervical lymph node, and a tumor marker for head and neck cancer used therein. Specifically, provided is a method for analyzing metastasis of head and neck cancer to a cervical lymph node, involving: measuring an expression level of at least one gene selected from the group consisting of genes represented by SEQ ID NOS: 1 to 36 in the sequence listing in a cervical lymph node sample; and comparing the aforementioned expression level with a reference value. Also provided is a tumor marker for head and neck cancer used in the aforementioned method for analyzing cervical lymph node metastasis, including at least one gene selected from the group consisting of genes represented by SEQ ID NOS: 1 to 36 in the sequence listing, and/or an expression product of the aforementioned gene and/or an expression level thereof.
摘要翻译： 本发明提供了一种分析头颈癌与宫颈淋巴结转移的方法，以及其中使用的头颈癌的肿瘤标志物。 具体而言，提供了一种分析头颈癌与颈淋巴结转移的方法，其特征在于：测定序列号1〜36所示的基因中至少一种选自下组的基因的表达量： 列在颈部淋巴结样本中; 并将上述表达水平与参考值进行比较。 还提供了上述用于分析颈淋巴结转移的方法中的头颈癌的肿瘤标记物，包括选自序列表中SEQ ID NO：1〜36所示基因的至少一种基因，以及 /或上述基因的表达产物和/或其表达水平。
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4.发明申请Method for analyzing cervical lymph node metastasis, and tumor marker for head and neck cancer 失效宫颈淋巴结转移分析方法及头颈癌肿瘤标志物公开(公告)号：US20120270218A1
公开(公告)日：2012-10-25
申请号：US13518656
申请日：2010-12-22
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/158
摘要： Provided are a method for analyzing metastasis of head and neck cancer to a cervical lymph node, and a tumor marker for head and neck cancer used therein. Specifically, provided is a method for analyzing metastasis of head and neck cancer to a cervical lymph node, involving: measuring an expression level of at least one gene selected from the group consisting of genes represented by SEQ ID NOS: 1 to 36 in the sequence listing in a cervical lymph node sample; and comparing the aforementioned expression level with a reference value. Also provided is a tumor marker for head and neck cancer used in the aforementioned method for analyzing cervical lymph node metastasis, including at least one gene selected from the group consisting of genes represented by SEQ ID NOS: 1 to 36 in the sequence listing, and/or an expression product of the aforementioned gene and/or an expression level thereof.
摘要翻译： 本发明提供了一种分析头颈癌与宫颈淋巴结转移的方法，以及其中使用的头颈癌的肿瘤标志物。 具体而言，提供了一种分析头颈癌与颈淋巴结转移的方法，其特征在于：测定序列号1〜36所示的基因中至少一种选自下组的基因的表达量： 列在颈部淋巴结样本中; 并将上述表达水平与参考值进行比较。 还提供了上述用于分析颈淋巴结转移的方法中的头颈癌的肿瘤标记物，包括选自序列表中SEQ ID NO：1〜36所示基因的至少一种基因，以及 /或上述基因的表达产物和/或其表达水平。
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