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1.发明授权Bis(arylmethylidene)acetone compound, anti-cancer agent, carcinogenesis-preventive agent, inhibitor of expression of Ki-Ras, ErbB2, c-Myc and Cycline D1, β-catenin-degrading agent, and p53 expression enhancer 有权双（芳基亚甲基）丙酮化合物，抗癌剂，致癌作用预防剂，Ki-Ras，ErbB2，c-Myc和Cycline D1，b-cadherin降解剂和p53表达增强子表达抑制剂公开(公告)号：US08178727B2
公开(公告)日：2012-05-15
申请号：US11993840
申请日：2006-06-27
IPC分类号： C07C49/217 , A61K31/12
CPC分类号： C07C247/04 , C07C49/223 , C07C49/248 , C07C49/255 , C07C205/45
摘要： It has been demanded to improve the poor solubility of curcumin to develop an anti-tumor compound capable of inhibiting the growth of various cancer cells at a low concentration. Thus, disclosed is a novel synthetic compound, a bis(arylmethylidene)acetone, which has both of an excellent anti-tumor activity and a chemo-preventive activity. A bis(arylmethylidene)acetone (i.e., a derivative having a curcumin skeleton) which is an anti-tumor compound and has a chemo-preventive activity is synthesized and screened. A derivative having enhanced anti-tumor activity and chemo-preventive activity can be synthesized.
摘要翻译： 已经要求提高姜黄素的溶解性差，开发能够抑制各种癌细胞生长低浓度的抗肿瘤化合物。 因此，公开了具有优异的抗肿瘤活性和化学预防活性的新型合成化合物双（芳基亚甲基）丙酮。 合成并筛选作为抗肿瘤化合物并具有化学预防活性的双（芳基亚甲基）丙酮（即具有姜黄素骨架的衍生物）。 可以合成具有增强的抗肿瘤活性和化学预防活性的衍生物。
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2.发明申请BIS(ARYLMETHYLIDENE)ACETONE COMPOUND, ANTI-CANCER AGENT, CARCINOGENESIS-PREVENTIVE AGENT, INHIBITOR OF EXPRESSION OF Ki-Ras, ErbB2, c-Myc AND CYCLINE D1, BETA-CATENIN-DEGRADING AGENT, AND p53 EXPRESSION ENHANCER 有权BIS（ARYLMETHYLIDENE）ACETONE化合物，抗癌剂，致癌作用剂，Ki-Ras，ErbB2，c-Myc和CYCLINE D1表达抑制剂，β-CATENIN降解剂和p53表达增强剂公开(公告)号：US20100152493A1
公开(公告)日：2010-06-17
申请号：US11993840
申请日：2006-06-27
IPC分类号： C07C49/217
CPC分类号： C07C247/04 , C07C49/223 , C07C49/248 , C07C49/255 , C07C205/45
摘要： It has been demanded to improve the poor solubility of curcumin to develop an anti-tumor compound capable of inhibiting the growth of various cancer cells at a low concentration. Thus, disclosed is a novel synthetic compound, a bis(arylmethylidene)acetone, which has both of an excellent anti-tumor activity and a chemo-preventive activity. A bis(arylmethylidene)acetone (i.e., a derivative having a curcumin skeleton) which is an anti-tumor compound and has a chemo-preventive activity is synthesized and screened. A derivative having enhanced anti-tumor activity and chemo-preventive activity can be synthesized.
摘要翻译： 已经要求提高姜黄素的溶解性差，开发能够抑制各种癌细胞生长低浓度的抗肿瘤化合物。 因此，公开了具有优异的抗肿瘤活性和化学预防活性的新型合成化合物双（芳基亚甲基）丙酮。 合成并筛选作为抗肿瘤化合物并具有化学预防活性的双（芳基亚甲基）丙酮（即具有姜黄素骨架的衍生物）。 可以合成具有增强的抗肿瘤活性和化学预防活性的衍生物。
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