公开(公告)号：US20180037930A1

公开(公告)日：2018-02-08

申请号：US15548574

申请日：2015-02-23

Applicant: Hitachi High-Technologies Corporation

Inventor： Manami NAMMOKU ,  Terumi TAMURA ,  Kohshi MAEDA ,  Daisuke MORISHIMA ,  Toshinari SAKURAI ,  Wataru SATO

IPC: C12Q1/68 ,  B01L7/00

Abstract: The purpose of the invention is to provide a nucleic acid analyzer that sets and executes temperature regulation, said temperature regulation matching the characteristics of analyzing items and the configuration of the analyzer, by a simple operation while preventing deterioration in analytical performance caused by partial overheating of a liquid reaction mixture to thereby improve temperature change speed and shorten analysis time. To achieve the above purpose, provided is a method wherein, in the case of performing overshooting: as a first processing, the temperature is continuously elevated until reaching a target overshoot temperature; as a second processing, after reaching the aforesaid temperature, the overshoot target temperature is maintained for a preset period of time; and, as a third processing, the temperature is continuously lowered until reaching a target temperature of the liquid reaction mixture. By executing the first to third processings, regulation is conducted so that temperature measurement values are in a trapezoidal form.

公开(公告)号：US20160144366A1

公开(公告)日：2016-05-26

申请号：US14898286

申请日：2014-06-18

Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

Inventor： Kimikazu SUGIYAMA ,  Minoru SANO ,  Yasunori SHOJI ,  Yoshiyuki SHOJI ,  Yuki KIKUCHI ,  Manami NAMMOKU ,  Ryoji INABA

IPC: B01L7/00

CPC classification number: B01L7/52 ,  B01L2300/046 ,  B01L2300/0609 ,  B01L2300/0654 ,  B01L2300/0803 ,  B01L2300/1822 ,  B01L2300/1844 ,  B01L2300/1883

Abstract: When taking in outside air with a fan to control the temperature inside a covered portion where a specimen is installed, the internal temperature may change depending on an environment temperature to cause a difference in temperature control. The wind generated by the fan may blow against a reaction container depending on its loading position and it may influence the temperature control over individual specimens and lead to problems with temperature accuracy, temperature rise speed, and temperature drop speed A reaction container avoiding these problems has a covered portion which performs temperature control on the reaction container and in which a cover and a fin cover have a heat insulating structure. A heat source is provided for controlling an internal temperature of an internal covered space. The internal temperature is kept constant and the influence of the environment temperature over the temperature control of the reaction container is minimized.

Abstract translation: 当用风扇吸入外部空气来控制安装样品的覆盖部分内的温度时，内部温度可能根据环境温度而变化，从而导致温度差异。 风扇产生的风可能会因反应容器的装载位置而受到冲击，可能影响单个样品的温度控制，导致温度精度，升温速度和温度下降速度的问题。避免这些问题的反应容器 在反应容器上进行温度控制的盖部，盖和翅片盖具有隔热结构。 提供了一种用于控制内部覆盖空间的内部温度的热源。 内部温度保持恒定，并且环境温度对反应容器的温度控制的影响最小化。

公开(公告)号：US20160245690A1

公开(公告)日：2016-08-25

申请号：US14913809

申请日：2014-07-03

Applicant: Hitachi High-Technologies Corporation

Inventor： Manami NAMMOKU ,  Kohshi MAEDA ,  Takehiko HOSOIRI ,  Yasunori SHOJI

IPC: G01J1/44 ,  G01N1/38 ,  G01N1/30

CPC classification number: G01J1/44 ,  G01J2001/444 ,  G01N1/30 ,  G01N1/38 ,  G01N21/51 ,  G01N21/645

Abstract: A nucleic acid analysis device is provided that is capable of quickly detecting device abnormalities, and the like. This device is provided with a temperature control block (1) for holding a tube (10) that includes a sample, a photometer (6), and a device diagnosis unit. The photometer (6) is provided with an LED (11) for irradiating light toward the temperature control block (1) in a state in which the tube (10) is held and a fluorescence detector (20) for receiving light emitted by the sample in response to the irradiation of light from the LED (11). The device diagnosis unit causes the LED (11) to irradiate light toward the temperature control block (1) in a state in which the tube (10) is not held, causes the fluorescence detector (20) to detect the resulting scattered light, and diagnoses the photometer (6) on the basis of the intensity of the scattered light.

Abstract translation: 提供能够快速检测装置异常的核酸分析装置等。 该装置设置有用于保持包括样品的管（10）的温度控制块（1），光度计（6）和设备诊断单元。 光度计（6）具有在保持管（10）的状态下朝向温度控制块（1）照射光的LED（11）和用于接收由样品发出的光的荧光检测器（20） 响应于来自LED（11）的光的照射。 设备诊断单元使得LED（11）在不保持管（10）的状态下朝向温度控制块（1）照射光，使得荧光检测器（20）检测所得到的散射光，并且 基于散射光的强度来诊断光度计（6）。