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1.发明申请Novel amphiphilic substance, and drug delivery system and molecular imaging system using the same 有权新型两亲物质，以及药物输送系统和分子成像系统使用相同公开(公告)号：US20080019908A1
公开(公告)日：2008-01-24
申请号：US11812131
申请日：2007-06-15
申请人： Hitoshi Akitsu , Eiichi Ozeki , Ryoji Fushimi , Shunsaku Kimura , Masashi Isozaki , Shigenori Nozawa
发明人： Hitoshi Akitsu , Eiichi Ozeki , Ryoji Fushimi , Shunsaku Kimura , Masashi Isozaki , Shigenori Nozawa
CPC分类号： C08G69/10 , A61K49/0034 , A61K49/0043 , A61K49/0052 , A61K49/0093 , B82Y5/00
摘要： The present invention provides a novel amphiphilic substance, a nanoparticle using the novel amphiphilic substance, which can be used as a nanocarrier having high biocompatibility, a drug delivery system and a probe useful for the system, and, a molecular imaging system and a probe useful for the system. An amphiphilic block polymer comprising a hydrophilic block; and a hydrophobic block, wherein the hydrophilic block is a hydrophilic polypeptide chain having 10 or more sarcosine units, and the hydrophobic block is a hydrophobic molecular chain comprising units selected from the group consisting of amino acid units and hydroxyl acid units as essential structural units, and having 5 or more of the essential structural units.
摘要翻译： 本发明提供一种新颖的两亲物质，使用该新型两亲性物质的纳米粒子，其可以用作具有高生物相容性的纳米载体，药物递送系统和可用于该系统的探针，以及分子成像系统和有用的探针 为系统。 包含亲水嵌段的两亲嵌段聚合物; 和疏水嵌段，其中所述亲水嵌段是具有10个或更多个肌氨酸单元的亲水性多肽链，疏水嵌段是包含选自氨基酸单元和羟基酸单元作为必需结构单元的单元的疏水分子链， 并具有5个以上的基本结构单元。
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2.发明授权Amphiphilic substance, and drug delivery system and molecular imaging system using the same 有权两亲物质，药物输送系统和分子成像系统使用相同公开(公告)号：US08945526B2
公开(公告)日：2015-02-03
申请号：US11812131
申请日：2007-06-15
申请人： Hitoshi Akitsu , Eiichi Ozeki , Ryoji Fushimi , Shunsaku Kimura , Masashi Isozaki , Shigenori Nozawa
发明人： Hitoshi Akitsu , Eiichi Ozeki , Ryoji Fushimi , Shunsaku Kimura , Masashi Isozaki , Shigenori Nozawa
CPC分类号： C08G69/10 , A61K49/0034 , A61K49/0043 , A61K49/0052 , A61K49/0093 , B82Y5/00
摘要： The present invention provides a novel amphiphilic substance, a nanoparticle using the novel amphiphilic substance, which can be used as a nanocarrier having high biocompatibility, a drug delivery system and a probe useful for the system, and, a molecular imaging system and a probe useful for the system. An amphiphilic block polymer comprising a hydrophilic block; and a hydrophobic block, wherein the hydrophilic block is a hydrophilic polypeptide chain having 10 or more sarcosine units, and the hydrophobic block is a hydrophobic molecular chain comprising units selected from the group consisting of amino acid units and hydroxyl acid units as essential structural units, and having 5 or more of the essential structural units.
摘要翻译： 本发明提供一种新颖的两亲物质，使用该新型两亲性物质的纳米粒子，其可以用作具有高生物相容性的纳米载体，药物递送系统和可用于该系统的探针，以及分子成像系统和有用的探针 为系统。 包含亲水嵌段的两亲嵌段聚合物; 和疏水嵌段，其中所述亲水嵌段是具有10个或更多个肌氨酸单元的亲水性多肽链，疏水嵌段是包含选自氨基酸单元和羟基酸单元作为必需结构单元的单元的疏水分子链， 并具有5个以上的基本结构单元。
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