公开(公告)号：US07563872B2

公开(公告)日：2009-07-21

申请号：US11853899

申请日：2007-09-12

申请人： Ho-Yong Park ,  Kwang-Hee Son ,  Doo-Sang Park ,  Sang-Woon Shin ,  Hyun-Woo Oh ,  Mi-Gwang Kim ,  Dong-Ha Shin

发明人： Ho-Yong Park ,  Kwang-Hee Son ,  Doo-Sang Park ,  Sang-Woon Shin ,  Hyun-Woo Oh ,  Mi-Gwang Kim ,  Dong-Ha Shin

IPC分类号： C07K14/00

CPC分类号： A61Q19/00 ,  A61K8/66 ,  A61K38/00 ,  A61K2800/86 ,  C11D3/386 ,  C12N9/52

摘要： The present invention relates to a protease, and more specifically to a protease derived from Aranicola proteolyticus, a gene coding for said enzyme, a gene expression system for said protease, a process for purifying the protease, and the uses of said protease in industrial applications, such as for example, detergents, cosmetics, leather processing agents, chemicals for laboratory research, solubilizing or softening agents for food, meat modifier, feed or food additives, or oil and fat separating agents, as well as pharmaceutical compositions.

摘要翻译： 本发明涉及一种蛋白酶，更具体地说涉及来源于蛋白水解伞菌的蛋白酶，编码所述酶的基因，所述蛋白酶的基因表达系统，蛋白酶的纯化方法以及所述蛋白酶在工业应用中的用途 ，例如洗涤剂，化妆品，皮革加工剂，用于实验室研究的化学品，用于食品的增溶或软化剂，肉改性剂，饲料或食品添加剂或油脂分离剂，以及药物组合物。

公开(公告)号：US20080069846A1

公开(公告)日：2008-03-20

申请号：US11853899

申请日：2007-09-12

申请人： Ho-Yong Park ,  Kwang-Hee Son ,  Doo-Sang Park ,  Sang-Woon Shin ,  Hyun-Woo Oh ,  Mi-Gwang Kim ,  Dong-Ha Shin

发明人： Ho-Yong Park ,  Kwang-Hee Son ,  Doo-Sang Park ,  Sang-Woon Shin ,  Hyun-Woo Oh ,  Mi-Gwang Kim ,  Dong-Ha Shin

IPC分类号： A61K8/02 ,  A61K38/48 ,  C07H21/04 ,  C11D3/386 ,  C12N15/00 ,  C12N5/02

CPC分类号： A61Q19/00 ,  A61K8/66 ,  A61K38/00 ,  A61K2800/86 ,  C11D3/386 ,  C12N9/52

摘要： The present invention relates to a protease, and more specifically to a protease derived from Aranicola proteolyticus, a gene coding for said enzyme, a gene expression system for said protease, a process for purifying the protease, and the uses of said protease in industrial applications, such as for example, detergents, cosmetics, leather processing agents, chemicals for laboratory research, solubilizing or softening agents for food, meat modifier, feed or food additives, or oil and fat separating agents, as well as pharmaceutical compositions.

摘要翻译： 本发明涉及一种蛋白酶，更具体地说涉及来源于蛋白水解伞菌的蛋白酶，编码所述酶的基因，所述蛋白酶的基因表达系统，蛋白酶的纯化方法以及所述蛋白酶在工业应用中的用途 ，例如洗涤剂，化妆品，皮革加工剂，用于实验室研究的化学品，用于食品的增溶或软化剂，肉改性剂，饲料或食品添加剂或油脂分离剂，以及药物组合物。

公开(公告)号：US07297332B2

公开(公告)日：2007-11-20

申请号：US09958321

申请日：2000-12-29

申请人： Ho-Yong Park ,  Kwang-Hee Son ,  Doo-Sang Park ,  Sang-Woon Shin ,  Hyun-Woo Oh ,  Mi-Gwang Kim ,  Dong-Ha Shin

发明人： Ho-Yong Park ,  Kwang-Hee Son ,  Doo-Sang Park ,  Sang-Woon Shin ,  Hyun-Woo Oh ,  Mi-Gwang Kim ,  Dong-Ha Shin

IPC分类号： A61K38/43 ,  C07K1/00 ,  C12N9/00 ,  C12N9/52

CPC分类号： A61Q19/00 ,  A61K8/66 ,  A61K38/00 ,  A61K2800/86 ,  C11D3/386 ,  C12N9/52

摘要： The present invention relates to a protease, and more specifically to a protease derived from Aranicola proteolyticus, a gene coding for said enzyme, a gene expression system for said protease, a process for purifying the protease, and the uses of said protease in industrial applications, such as for example, detergents, cosmetics, leather processing agents, chemicals for laboratory research, solubilizing or softening agents for food, meat modifier, feed or food additives, or oil and fat separating agents, as well as pharmaceutical compositions.

摘要翻译： 本发明涉及一种蛋白酶，更具体地说涉及来源于蛋白水解伞菌的蛋白酶，编码所述酶的基因，所述蛋白酶的基因表达系统，蛋白酶的纯化方法以及所述蛋白酶在工业应用中的用途 ，例如洗涤剂，化妆品，皮革加工剂，用于实验室研究的化学品，用于食品的增溶或软化剂，肉改性剂，饲料或食品添加剂或油脂分离剂，以及药物组合物。

公开(公告)号：US08362034B2

公开(公告)日：2013-01-29

申请号：US13462727

申请日：2012-05-02

申请人： Ho Yong Park ,  Tae-Sook Jeong ,  Hyun-Woo Oh ,  Woo-Song Lee ,  Doo-Sang Park ,  Jong-Min Han

发明人： Ho Yong Park ,  Tae-Sook Jeong ,  Hyun-Woo Oh ,  Woo-Song Lee ,  Doo-Sang Park ,  Jong-Min Han

IPC分类号： C07D215/26 ,  A61P3/06 ,  A61P9/10 ,  A61P9/00 ,  A61K31/47

CPC分类号： C07D215/26

摘要： The present invention relates to a composition for the prevention and treatment of cardiovascular diseases containing the novel quinoline compound, the centipede extracts or compounds isolated from the extracts. The novel quinoline compound, the centipede extracts or a quinoline compound and a phenol compound isolated from the extracts of the invention exhibit excellent LDL-antioxidant activity, ACAT inhibiting activity, and anti-inflammatory activities, so that they can be included as an effective ingredient in a composition for the prevention and treatment of cardiovascular disease including hyperlipidemia, atherosclerosis, coronary heart disease, and myocardial infarction mediated by LDL-oxidation, cholesteryl ester synthesis and accumulation, and inflammation.

摘要翻译： 本发明涉及用于预防和治疗含有新喹啉化合物，蜈蚣提取物或从提取物分离的化合物的心血管疾病的组合物。 从本发明提取物中分离的新颖喹啉化合物，蜈蚣提取物或喹啉化合物和酚化合物表现出优异的LDL-抗氧化活性，ACAT抑制活性和抗炎活性，因此它们可以作为有效成分 用于预防和治疗心血管疾病的组合物，包括高脂血症，动脉粥样硬化，冠心病和LDL氧化，胆固醇酯合成和积累介导的心肌梗死以及炎症。

公开(公告)号：US08212042B2

公开(公告)日：2012-07-03

申请号：US12084467

申请日：2006-05-19

申请人： Ho Yong Park ,  Tae-Sook Jeong ,  Hyun-Woo Oh ,  Woo-Song Lee ,  Doo-Sang Park ,  Jong-Min Han

发明人： Ho Yong Park ,  Tae-Sook Jeong ,  Hyun-Woo Oh ,  Woo-Song Lee ,  Doo-Sang Park ,  Jong-Min Han

IPC分类号： C07D215/24

CPC分类号： C07D215/26

摘要： The present invention relates to a composition for the prevention and treatment of cardiovascular diseases containing the novel quinoline compound, the centipede extracts or compounds isolated from the extracts. The novel quinoline compound, the centipede extracts or a quinoline compound and a phenol compound isolated from the extracts of the invention exhibit excellent LDL-antioxidant activity, ACAT inhibiting activity, and anti-inflammatory activities, so that they can be included as an effective ingredient in a composition for the prevention and treatment of cardiovascular disease including hyperlipidemia, atherosclerosis, coronary heart disease, and myocardial infarction mediated by LDL-oxidation, cholesteryl ester synthesis and accumulation, and inflammation.

摘要翻译： 本发明涉及用于预防和治疗含有新喹啉化合物，蜈蚣提取物或从提取物分离的化合物的心血管疾病的组合物。 从本发明提取物中分离的新颖喹啉化合物，蜈蚣提取物或喹啉化合物和酚化合物表现出优异的LDL-抗氧化活性，ACAT抑制活性和抗炎活性，因此它们可以作为有效成分 用于预防和治疗心血管疾病的组合物，包括高脂血症，动脉粥样硬化，冠心病和LDL氧化，胆固醇酯合成和积累介导的心肌梗死以及炎症。

公开(公告)号：US20090247758A1

公开(公告)日：2009-10-01

申请号：US12084467

申请日：2006-05-19

申请人： Ho Yong Park ,  Tae-Sook Jeong ,  Hyun-Woo Oh ,  Woo-Song Lee ,  Doo-Sang Park ,  Jong-Min Han

发明人： Ho Yong Park ,  Tae-Sook Jeong ,  Hyun-Woo Oh ,  Woo-Song Lee ,  Doo-Sang Park ,  Jong-Min Han

IPC分类号： C07D215/24 ,  C07C39/06

CPC分类号： C07D215/26

摘要： The present invention relates to a composition for the prevention and treatment of cardiovascular diseases containing the novel quinoline compound, the centipede extracts or compounds isolated from the extracts. The novel quinoline compound, the centipede extracts or a quinoline compound and a phenol compound isolated from the extracts of the invention exhibit excellent LDL-antioxidant activity, ACAT inhibiting activity, and anti-inflammatory activities, so that they can be included as an effective ingredient in a composition for the prevention and treatment of cardiovascular disease including hyperlipidemia, atherosclerosis, coronary heart disease, and myocardial infarction mediated by LDL-oxidation, cholesteryl ester synthesis and accumulation, and inflammation.

摘要翻译： 本发明涉及用于预防和治疗含有新喹啉化合物，蜈蚣提取物或从提取物分离的化合物的心血管疾病的组合物。 从本发明提取物中分离的新颖喹啉化合物，蜈蚣提取物或喹啉化合物和酚化合物表现出优异的LDL-抗氧化活性，ACAT抑制活性和抗炎活性，因此它们可以作为有效成分 用于预防和治疗心血管疾病的组合物，包括高脂血症，动脉粥样硬化，冠心病和LDL氧化，胆固醇酯合成和积累介导的心肌梗死以及炎症。