公开(公告)号：US20220227878A1

公开(公告)日：2022-07-21

申请号：US17557647

申请日：2021-12-21

申请人： Hoffmann-La Roche Inc.

发明人： Peter BRUENKER ,  Harald DUERR ,  Christian KLEIN ,  Pablo UMANA ,  Alexander BUJOTZEK ,  Joerg ZIELONKA ,  Christine TRUMPFHELLER ,  Moritz RAPP ,  Marine LE CLECH

IPC分类号： C07K16/28 ,  A61P35/00 ,  A61K39/395 ,  C07K1/16 ,  C07K16/40

摘要： The invention relates to novel bispecific antigen binding molecules, comprising (a) at least one antigen binding domain capable of specific binding to Fibroblast Activation Protein (FAP) comprising FAP clone 212 or variants thereof, and (b) at least one antigen binding domain capable of specific binding to CD40, and to methods of producing these molecules and to methods of using the same.

公开(公告)号：US20180340030A1

公开(公告)日：2018-11-29

申请号：US15943821

申请日：2018-04-03

申请人： Hoffmann-La Roche Inc.

发明人： Peter BRUENKER ,  Alexander BUJOTZEK ,  Harald DUERR ,  Guy GEORGES ,  Christian KLEIN ,  Stephane LECLAIR ,  Moritz RAPP ,  Eva Carina SUM ,  Christine TRUMPFHELLER ,  Pablo UMAÑA

IPC分类号： C07K16/28 ,  A61P35/00

摘要： The invention relates to novel bispecific antigen binding molecules, comprising (a) at least one antigen binding domain capable of specific binding to CD40, and (b) at least one antigen binding domain capable of specific binding to a target cell antigen, in particular Fibroblast Activation Protein (FAP), and to methods of producing these molecules and to methods of using the same.

公开(公告)号：US20210292426A1

公开(公告)日：2021-09-23

申请号：US17218752

申请日：2021-03-31

申请人： Hoffmann-La Roche Inc.

发明人： Harald DUERR ,  Moritz RAPP ,  Christine TRUMPFHELLER ,  Pablo UMANA

IPC分类号： C07K16/28 ,  C07K16/40 ,  A61K45/06 ,  A61K39/395

摘要： The invention relates to novel bispecific antigen binding molecules with trivalent binding to CD40 and monovalent binding to a target cell antigen and to methods of producing these molecules and to methods of using the same.

公开(公告)号：US20230181712A1

公开(公告)日：2023-06-15

申请号：US17924645

申请日：2021-05-10

申请人： Hoffmann-La Roche Inc.

发明人： Pablo UMAÑA ,  Christian KLEIN ,  Christine TRUMPFHELLER ,  Valeria G. NICOLINI ,  Laura CODARRI DEAK ,  Scott LOUGHHEAD ,  Matthew BOOTY

IPC分类号： A61K39/12 ,  A61K47/68 ,  A61K35/17 ,  A61K39/39 ,  C12N15/117

CPC分类号： A61K39/12 ,  A61K47/6851 ,  A61K47/6813 ,  A61K35/17 ,  A61K39/39 ,  C12N15/117 ,  A61K2039/6006

摘要： The present application provides methods for stimulating an immune response in an individual comprising administering a composition of nucleated cells (e.g., PBMCs) comprising an intracellular exogenous antigen in conjunction with administering an immunoconjugate comprising a variant IL-2 polypeptide and a second polypeptide. The variant IL-2 polypeptide exhibits reduced affinity to the α-subunit of the IL-2 receptor. The second polypeptide targets a tumor cell or a T cell.

公开(公告)号：US20210188992A1

公开(公告)日：2021-06-24

申请号：US17179223

申请日：2021-02-18

申请人： Hoffmann-La Roche Inc.

发明人： Peter BRUENKER ,  Alexander BUJOTZEK ,  Harald DUERR ,  Guy GEORGES ,  Christian KLEIN ,  Stephane LECLAIR ,  Moritz RAPP ,  Eva Carina SUM ,  Christine TRUMPFHELLER ,  Pablo UMAÑA

IPC分类号： C07K16/28 ,  C07K16/40 ,  A61P35/00

摘要： The invention relates to novel bispecific antigen binding molecules, comprising (a) at least one antigen binding domain capable of specific binding to CD40, and (b) at least one antigen binding domain capable of specific binding to a target cell antigen, in particular Fibroblast Activation Protein (FAP), and to methods of producing these molecules and to methods of using the same.