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公开(公告)号：US20240042022A1
公开(公告)日：2024-02-08
申请号：US18244135
申请日：2023-09-08
发明人： Anne FREIMOSER-GRUNDSCHOBER , Thomas HOFER , Ralf HOSSE , Ekkehard MOESSNER , Valeria G. NICOLINI , Pablo UMAÑA , Inja WALDHAUER , Wolfgang RICHTER , Alexander KNAUPP , Halina TROCHANOWSKA
IPC分类号： A61K39/395 , A61P35/00 , C07K16/28 , C07K16/30
CPC分类号： A61K39/39558 , A61P35/00 , C07K16/2809 , C07K16/2863 , C07K16/3053 , A61K2039/505
摘要： The present invention generally relates to antibodies that bind to CD3, including multispecific antibodies e.g. for activating T cells. In addition, the present invention relates to polynucleotides encoding such antibodies, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the antibodies, and to methods of using them in the treatment of disease.
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公开(公告)号：US20230181712A1
公开(公告)日：2023-06-15
申请号：US17924645
申请日：2021-05-10
发明人： Pablo UMAÑA , Christian KLEIN , Christine TRUMPFHELLER , Valeria G. NICOLINI , Laura CODARRI DEAK , Scott LOUGHHEAD , Matthew BOOTY
IPC分类号： A61K39/12 , A61K47/68 , A61K35/17 , A61K39/39 , C12N15/117
CPC分类号： A61K39/12 , A61K47/6851 , A61K47/6813 , A61K35/17 , A61K39/39 , C12N15/117 , A61K2039/6006
摘要： The present application provides methods for stimulating an immune response in an individual comprising administering a composition of nucleated cells (e.g., PBMCs) comprising an intracellular exogenous antigen in conjunction with administering an immunoconjugate comprising a variant IL-2 polypeptide and a second polypeptide. The variant IL-2 polypeptide exhibits reduced affinity to the α-subunit of the IL-2 receptor. The second polypeptide targets a tumor cell or a T cell.
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公开(公告)号：US20230277662A1
公开(公告)日：2023-09-07
申请号：US18307400
申请日：2023-04-26
发明人： Anne FREIMOSER-GRUNDSCHOBER , Thomas HOFER , Ralf HOSSE , Ekkehard MOESSNER , Valeria G. NICOLINI , Pablo UMAÑA , Inja WALDHAUER , Wolfgang RICHTER , Alexander KNAUPP , Halina TROCHANOWSKA
IPC分类号： A61K39/395 , C07K16/28 , C07K16/30 , A61P35/00 , A61K39/00
CPC分类号： A61K39/39558 , A61P35/00 , C07K16/2809 , C07K16/2863 , C07K16/3053 , A61K2039/505 , C07K2317/31 , C07K2317/55 , C07K2317/565
摘要： The present invention generally relates to antibodies that bind to CD3, including multispecific antibodies e.g. for activating T cells. In addition, the present invention relates to polynucleotides encoding such antibodies, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the antibodies, and to methods of using them in the treatment of disease.
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4.发明申请COMBINATION THERAPY OF TUMOR-TARGETED IL-2 VARIANT IMMUNOCYTOKINES AND ANTIBODIES AGAINST HUMAN PD-L1 审中-公开肿瘤标志物IL-2变体免疫球蛋白和抗PD-L1抗体的组合疗法公开(公告)号：US20160175397A1
公开(公告)日：2016-06-23
申请号：US14839410
申请日：2015-08-28
IPC分类号： A61K38/20 , A61K39/395 , A61K39/00
CPC分类号： A61K38/2013 , A61K39/0011 , A61K39/3955 , A61K47/6813 , A61K47/6849 , A61K47/6853 , A61K47/6871 , A61K2039/505 , A61K2039/507 , A61K2039/575 , C07K14/55 , C07K16/2827 , C07K16/3007 , C07K16/40 , C07K2317/52 , C07K2317/71 , C07K2317/732 , C07K2317/76 , C07K2319/33 , A61K2300/00
摘要： The present invention relates to the combination therapy of specific tumor-targeted IL-2 variant immunocytokines with specific antibodies which bind human PD-L1.
摘要翻译： 本发明涉及特异性肿瘤靶向IL-2变体免疫细胞因子与结合人PD-L1的特异性抗体的组合疗法。
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公开(公告)号：US20210403562A1
公开(公告)日：2021-12-30
申请号：US17474980
申请日：2021-09-14
发明人： Anne FREIMOSER-GRUNDSCHOBER , Thomas HOFER , Ralf HOSSE , Ekkehard MOESSNER , Valeria G. NICOLINI , Pablo UMAÑA , Inja WALDHAUER , Wolfgang RICHTER , Alexander KNAUPP , Halina TROCHANOWSKA
摘要： The present invention generally relates to antibodies that bind to CD3, including multi specific antibodies e.g. for activating T cells. In addition, the present invention relates to polynucleotides encoding such antibodies, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the antibodies, and to methods of using them in the treatment of disease.
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6.发明公开公开(公告)号：US20240092856A1
公开(公告)日：2024-03-21
申请号：US18549879
申请日：2022-03-08
发明人： Marina BACAC , Christina CLAUS , Laura CODARRI DEAK , Sara COLOMBETTI , Christian KLEIN , Valeria G. NICOLINI , Mario PERRO , Johannes SAM , Christine TRUMPFHELLER , Pablo UMAÑA
CPC分类号： C07K14/55 , A61P35/00 , C07K16/2809 , C07K16/2818 , C07K16/2878 , C07K16/3007 , A61K2039/507 , C07K2317/31 , C07K2319/33
摘要： The present invention relates to the combination therapy of specific PD-1-targeted IL-2 variant immunoconjugates with specific antibodies which bind human FAP and 4-1BB and optionally with an anti-CEA/anti-CD3 bispecific antibody.
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公开(公告)号：US20200270347A1
公开(公告)日：2020-08-27
申请号：US16721254
申请日：2019-12-19
发明人： Anne FREIMOSER-GRUNDSCHOBER , Thomas HOFER , Ralf HOSSE , Ekkehard MOESSNER , Valeria G. NICOLINI , Pablo UMAÑA , lnja WALDHAUER , Wolfgang Richter , Alexander KNAUPP , Halina TROCHANOWSKA
摘要： The present invention generally relates to antibodies that bind to CD3, including multispecific antibodies e.g. for activating T cells. In addition, the present invention relates to polynucleotides encoding such antibodies, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the antibodies, and to methods of using them in the treatment of disease.
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