公开(公告)号：US20230287412A1

公开(公告)日：2023-09-14

申请号：US17986101

申请日：2022-11-14

申请人： Hoffmann-La Roche Inc.

发明人： Ravi Jagasia ,  Lars Joenson ,  Soren Rasmussen ,  Disa Tehler ,  Dorthe Vang Larsen ,  Jesper Worm

IPC分类号： C12N15/113 ,  A61P25/00

CPC分类号： C12N15/113 ,  A61P25/00 ,  C12N2310/11 ,  C12N2310/3231 ,  C12N2310/3341 ,  C12N2310/315

摘要： The present invention relates to oligonucleotides which up-regulate or restore the expression of progranulin in cells, and their use in the treatment of neurological disorders, and disorders associated with progranulin haploinsufficiency.

公开(公告)号：US20220204973A1

公开(公告)日：2022-06-30

申请号：US17552804

申请日：2021-12-16

申请人： Hoffmann-La Roche Inc.

发明人： Ravi Jagasia ,  Lars Jonson ,  Soren Rasmussen ,  Jacob Ravn ,  Disa Tehler ,  Dorthe Vang ,  Jesper Worm

IPC分类号： C12N15/113 ,  C12N15/67

摘要： The present invention relates to oligonucleotides which alter the splicing pattern of progranulin in cells, and their use in the treatment of neurological disorders.

公开(公告)号：US12104153B2

公开(公告)日：2024-10-01

申请号：US17552804

申请日：2021-12-16

申请人： Hoffmann-La Roche Inc.

发明人： Ravi Jagasia ,  Lars Jonson ,  Soren Rasmussen ,  Jacob Ravn ,  Disa Tehler ,  Dorthe Vang ,  Jesper Worm

IPC分类号： C12N15/113 ,  C12N15/67

CPC分类号： C12N15/113 ,  C12N15/67 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/3231 ,  C12N2310/3341 ,  C12N2310/346

摘要： The present invention relates to oligonucleotides which alter the splicing pattern of progranulin in cells, and their use in the treatment of neurological disorders.