公开(公告)号：US20230192795A1

公开(公告)日：2023-06-22

申请号：US17996338

申请日：2021-04-13

申请人： Hoffmann-La Roche Inc.

发明人： Laura Codarri Deak ,  Anne Freimoser-Grundschober ,  Christian Klein ,  Laura Lauener ,  Ekkehard Moessner ,  Cindy Schulenburg ,  Pablo Umaña ,  Eleni Maria Varypataki

IPC分类号： C07K14/54 ,  C07K16/28 ,  A61P35/00

CPC分类号： C07K14/5418 ,  A61P35/00 ,  C07K16/2818 ,  A61K2039/505

摘要： The present invention generally relates to mutant interleukin-7 polypeptides, immunoconjugates, particularly immunoconjugates comprising a mutant interleukin-7 polypeptide and an antibody that binds to PD-1. In addition, the invention relates to polynucleotide molecules encoding the mutant interleukin-7 polypeptides or the immunoconjugates, and vectors and host cells comprising such polynucleotide molecules. The invention further relates to methods for producing the mutant interleukin-7 polypeptides, immunoconjugates, pharmaceutical compositions comprising the same, and uses thereof.