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公开(公告)号：US20230134606A1
公开(公告)日：2023-05-04
申请号：US17810041
申请日：2022-06-30
发明人： Laura Codarri Deak , Christian Klein , Laura Lauener , Valeria G. Nicolini , Stefan Seeber , Pablo Umana , Inja Waldhauer
摘要： The present invention generally relates to immunoconjugates, particularly immunoconjugates comprising a mutant interleukin-2 polypeptide and an antibody that binds to PD-1. In addition, the invention relates to polynucleotide molecules encoding the immunoconjugates, and vectors and host cells comprising such polynucleotide molecules. The invention further relates to methods for producing the mutant immunoconjugates, pharmaceutical compositions comprising the same, and uses thereof.
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公开(公告)号：US11413331B2
公开(公告)日：2022-08-16
申请号：US15943237
申请日：2018-04-02
发明人： Laura Codarri Deak , Christian Klein , Laura Lauener , Valeria G. Nicolini , Stefan Seeber , Pablo Umana , Inja Waldhauer
IPC分类号： A61K38/20 , A61K39/395 , C07K14/55 , C07K16/28 , A61K47/68 , A61P35/00 , A61K39/00 , A61K38/00
摘要： The present invention generally relates to immunoconjugates, particularly immunoconjugates comprising a mutant interleukin-2 polypeptide and an antibody that binds to PD-1. In addition, the invention relates to polynucleotide molecules encoding the immunoconjugates, and vectors and host cells comprising such polynucleotide molecules. The invention further relates to methods for producing the mutant immunoconjugates, pharmaceutical compositions comprising the same, and uses thereof.
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公开(公告)号：US20220387586A1
公开(公告)日：2022-12-08
申请号：US17653846
申请日：2022-03-07
发明人： Laura Codarri Deak , Jens Fischer , Sabine Imhof-Jung , Christian Klein , Stefan Seeber , Patrick Alexander Aaron Weber
摘要： The invention relates to bispecific antibodies comprising a first antigen binding domain that specifically binds to PD1 and a second antigen binding domain that specifically binds to LAG3. The invention further relates to methods of producing these molecules and to methods of using the same.
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公开(公告)号：US20180326011A1
公开(公告)日：2018-11-15
申请号：US15943264
申请日：2018-04-02
发明人： Laura Codarri Deak , Christian Klein , Laura Lauener , Stefan Seeber , Pablo Umana , Inja Waldhauer
CPC分类号： A61K38/2013 , A61K47/6813 , A61K47/6849 , A61K47/6851 , A61K2039/505 , A61P35/00 , C07K14/55 , C07K16/2818 , C07K2317/73 , C07K2319/74
摘要： The present invention generally relates to immunoconjugates, particularly immunoconjugates comprising a mutant interleukin-2 polypeptide and a bispecific antigen binding molecule that binds to PD-1 and Tim-3. In addition, the invention relates to polynucleotide molecules encoding the immunoconjugates, and vectors and host cells comprising such polynucleotide molecules. The invention further relates to methods for producing the mutant immunoconjugates, pharmaceutical compositions comprising the same, and uses thereof.
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公开(公告)号：US20230071733A1
公开(公告)日：2023-03-09
申请号：US17834096
申请日：2022-06-07
发明人： Laura Codarri Deak , Christian Klein , Laura Lauener , Stefan Seeber , Pablo Umana , Inja Waldhauer
摘要： The present invention generally relates to immunoconjugates, particularly immunoconjugates comprising a mutant interleukin-2 polypeptide and a bispecific antigen binding molecule that binds to PD-1 and Tim-3. In addition, the invention relates to polynucleotide molecules encoding the immunoconjugates, and vectors and host cells comprising such polynucleotide molecules. The invention further relates to methods for producing the mutant immunoconjugates, pharmaceutical compositions comprising the same, and uses thereof.
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公开(公告)号：US20180326054A1
公开(公告)日：2018-11-15
申请号：US15944394
申请日：2018-04-03
发明人： Laura Codarri Deak , Jens Fischer , Sabine Imhof-Jung , Christian Klein , Stefan Seeber , Patrick Alexander Aaron Weber
CPC分类号： A61K39/3955 , A61K35/17 , A61K39/001102 , A61K45/06 , A61K2039/505 , A61K2300/00 , A61P31/12 , A61P35/00 , C07K16/28 , C07K16/2803 , C07K16/2809 , C07K16/2818 , C07K2317/24 , C07K2317/31 , C07K2317/52 , C07K2317/522 , C07K2317/526 , C07K2317/71 , C07K2317/75 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2317/94 , C07K2319/30 , C07K2319/74 , C07K2319/75
摘要： The invention relates to bispecific antibodies comprising a first antigen binding domain that specifically binds to PD1 and a second antigen binding domain that specifically binds to LAG3. The invention further relates to methods of producing these molecules and to methods of using the same.
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公开(公告)号：US20180326010A1
公开(公告)日：2018-11-15
申请号：US15943237
申请日：2018-04-02
发明人： Laura Codarri Deak , Christian Klein , Laura Lauener , Valeria G. Nicolini , Stefan Seeber , Pablo Umana , Inja Waldhauer
CPC分类号： A61K38/2013 , A61K47/6813 , A61K47/6849 , A61K47/6891 , A61K2039/505 , A61P35/00 , C07K14/55 , C07K16/2818 , C07K2317/73 , C07K2319/74
摘要： The present invention generally relates to immunoconjugates, particularly immunoconjugates comprising a mutant interleukin-2 polypeptide and an antibody that binds to PD-1. In addition, the invention relates to polynucleotide molecules encoding the immunoconjugates, and vectors and host cells comprising such polynucleotide molecules. The invention further relates to methods for producing the mutant immunoconjugates, pharmaceutical compositions comprising the same, and uses thereof.
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公开(公告)号：US11285207B2
公开(公告)日：2022-03-29
申请号：US15944394
申请日：2018-04-03
发明人： Laura Codarri Deak , Jens Fischer , Sabine Imhof-Jung , Christian Klein , Stefan Seeber , Patrick Alexander Aaron Weber
IPC分类号： A61K39/00 , A61K39/395 , C07K16/30 , C07K16/28 , A61P31/12 , A61P35/00 , A61K35/17 , A61K45/06
摘要： The invention relates to bispecific antibodies comprising a first antigen binding domain that specifically binds to PD1 and a second antigen binding domain that specifically binds to LAG3. The invention further relates to methods of producing these molecules and to methods of using the same.
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公开(公告)号：US20190315868A1
公开(公告)日：2019-10-17
申请号：US16270334
申请日：2019-02-07
IPC分类号： C07K16/28 , A61P35/00 , C07K14/705
摘要： The present invention provides therapeutic and diagnostic methods and compositions for cancer and for enhancing immune function in an individual having cancer. The invention provides methods of treatment, methods for determining whether an individual suffering from a cancer is responding to treatment comprising a PD-1 axis binding antagonist, predicting responsiveness of an individual suffering from a cancer to treatment comprising a PD-1 axis binding antagonist, and methods of selecting a therapy for an individual suffering from cancer.
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公开(公告)号：US20170247454A1
公开(公告)日：2017-08-31
申请号：US15280810
申请日：2016-09-29
发明人： Joerg Benz , Laura Codarri Deak , Stefan Dengl , Sebastian Fenn , Jens Fischer , Guy Georges , Christian Klein , Viktor Levitski , Valeria Lifke , Oliver Ploettner , Stefan Seeber , Barbara Weiser , Ildiko Wuensche , Adrian Zwick
IPC分类号： C07K16/28
CPC分类号： C07K16/2818 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to anti-PD1 antibodies and methods of using the same.
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