专利检索 ap:("Hoffmann-La Roche Inc.") AND inv:"Weichun CHEN" 第 1 页

1.

发明申请
PROCESS FOR THE PREPARATION OF EXO-TERT-BUTYL N-(3-AZABICYCLO[3.2.1]OCTAN-8-YL)CARBAMATE 有权

公开(公告)号：US20220073469A1

公开(公告)日：2022-03-10

申请号：US17418480

申请日：2019-12-24

申请人： Hoffmann-La Roche Inc.

发明人： Weichun CHEN , Guocai ZHANG

IPC分类号： C07D221/22

摘要： The present invention relates to a process for the preparation of a compound (I) or pharmaceutically acceptable salt thereof, which is useful as the key intermediate for the synthesis of compounds for prophylaxis and treatment of a disease associated with the deposition of β-amyloid in the brain, in particular Alzheimer's disease, and other diseases such as cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, Dutch-type (HCHWA-D), multi-infarct dementia, dementia pugilistica and Down syndrome.

2.

发明申请
PROCESS FOR THE PREPARATION OF TETRAHYDROPYRIDOPYRIMIDINES 有权

公开(公告)号：US20220098189A1

公开(公告)日：2022-03-31

申请号：US17423069

申请日：2020-01-16

申请人： Hoffmann-La Roche Inc.

发明人： Junli CHEN , Weichun CHEN , Lin WANG

IPC分类号： C07D471/04

摘要： The present invention relates to a process for synthesizing a compound of formula (I), or a pharmaceutically acceptable salt thereof, which is useful for prophylaxis and treatment of a viral disease in a patient relating to hepatitis B infection or a disease caused by hepatitis B infection.

3.

发明申请
PROCESS FOR THE PREPARATION OF (9S)-2-BROMO-9-(2,3,4-TRIFLUOROPHENYL)-6,7,8,9-TETRAHYDRO-5H-[1,2,4]TRIAZOLO[1,5-A]AZEPINE 有权

公开(公告)号：US20230048657A1

公开(公告)日：2023-02-16

申请号：US17780127

申请日：2020-11-27

申请人： Hoffmann-La Roche Inc.

发明人： Weichun CHEN , Christian JENNY , Hasane RATNI , Guocai ZHANG , Fugui ZHANG

IPC分类号： C07D487/04 , C07C213/08 , C07C215/34 , C07C57/58 , C07C51/353 , C07C51/41 , C07C51/60 , C07C277/08

摘要： The present invention relates to a process for synthesizing large scale a compound of formula (I), or pharmacuetically acceptable salt thereof, which is useful as the key intermediate for the synthesis of compounds for prophylaxis and treatment of a disease associated with the deposition of β-amyloid in the brain, in particular Alzheimer's disease, and other diseases such as cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, Dutch-type (HCHWA-D), multi-infarct dementia, dementia pugilistica and Down syndrome.

4.

发明申请
PROCESS FOR THE PREPARATION OF (6S)-3-[(4S)-4-CYANO-2-OXO-PYRROLIDIN-1-YL]-6-METHYL-N-(3,4,5-TRIFLUOROPHENYL)-6,7-DIHYDRO-4H-PYRAZOLO[1,5-A]PYRAZINE-5-CARBOXAMIDE 有权

公开(公告)号：US20220162212A1

公开(公告)日：2022-05-26

申请号：US17433961

申请日：2020-02-25

申请人： Hoffmann-La Roche Inc.

发明人： Weichun CHEN , Lin WANG , Qiwu ZHAO

IPC分类号： C07D487/04 , C07D207/277

摘要： The present invention relates to a process for synthesizing a compound (I), or pharmaceutically acceptable salt thereof, which is useful for prophylaxis and treatment of a viral disease in a patient relating to hepatitis B infection or a disease caused by hepatitis B infection.