公开(公告)号：US20220370447A1

公开(公告)日：2022-11-24

申请号：US17761521

申请日：2020-09-18

申请人： Hoffmann-La Roche Inc.

发明人： Qingyan BO ,  Valérie COSSON ,  Sheng FENG ,  Lu GAO ,  Yuyan JIN ,  Annabelle LEMENUEL ,  Miriam TRIYATNI ,  Xue ZHOU ,  Mingfen ZHU

IPC分类号： A61K31/506 ,  A61P31/20 ,  A61K31/522 ,  A61K31/675 ,  A61K31/7068 ,  A61K38/21 ,  A61K31/496

摘要： The present invention relates to method of treating HBV infection in a human patient, wherein the method comprises administration of a therapeutically effective amount of Compound (I), or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20230119360A1

公开(公告)日：2023-04-20

申请号：US17843740

申请日：2022-06-17

申请人： Hoffmann-La Roche Inc.

发明人： Lu GAO ,  Yonghong ZHU ,  Søren OTTOSEN ,  Henrik MUELLER ,  Xue ZHOU ,  Julie Elisabeth Françoise BLAISING ,  Yuyan JIN ,  Qingyan BO ,  Gaurav TYAGI

IPC分类号： A61K31/519 ,  A61K48/00 ,  A61P31/20

摘要： The present invention is directed to compositions and methods for treating hepatitis B virus infection. In particular, the present invention is directed to a combination therapy comprising administration of a therapeutic oligonucleotide targeting HBV and a TLR7 agonist for use in the treatment of a chronic hepatitis B patient.