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公开(公告)号：US20180179252A1
公开(公告)日：2018-06-28
申请号：US15735394
申请日：2016-07-21
CPC分类号： C07K7/06 , A61K38/00 , A61K38/08 , A61K38/10 , A61K38/55 , A61P25/28 , C07K7/08 , C12N9/6478
摘要： The present invention relates to dual-site BACE1 inhibitors, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease.
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公开(公告)号：US20220275087A1
公开(公告)日：2022-09-01
申请号：US17541021
申请日：2021-12-02
发明人： Peter BRUENKER , Rebecca CROASDALE-WOOD , Christian KLEIN , Juergen Michael SCHANZER , Kay-Gunnar STUBENRAUCH , Pablo UMANA , Martina GEIGER , Eric SULLIVAN , Jigar PATEL
摘要： The present invention generally relates to novel protease-activatable T cell activating bispecific molecules and idiotype-specific polypeptides. The present invention also relates to polynucleotides encoding such protease-activatable T cell activating bispecific molecules and idiotype-specific polypeptides, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the protease-activatable T cell activating bispecific molecules and idiotype-specific polypeptides of the invention, and to methods of using these protease-activatable T cell activating bispecific molecules and idiotype-specific polypeptides in the treatment of disease.
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公开(公告)号：US20230119537A1
公开(公告)日：2023-04-20
申请号：US17843565
申请日：2022-06-17
发明人： Peter BRUENKER , Rebecca CROASDALE-WOOD , Christian KLEIN , Juergen Michael SCHANZER , Kay-Gunnar STUBENRAUCH , Pablo UMANA , Martina GEIGER , Eric SULLIVAN , Jigar PATEL
摘要： The present invention generally relates to novel protease-activatable T cell activating bispecific molecules and idiotype-specific polypeptides. The present invention also relates to polynucleotides encoding such protease-activatable T cell activating bispecific molecules and idiotype-specific polypeptides, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the protease-activatable T cell activating bispecific molecules and idiotype-specific polypeptides of the invention, and to methods of using these protease-activatable T cell activating bispecific molecules and idiotype-specific polypeptides in the treatment of disease.
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公开(公告)号：US20190119383A1
公开(公告)日：2019-04-25
申请号：US16138417
申请日：2018-09-21
发明人： Peter BRUENKER , Rebecca CROASDALE-WOOD , Christian KLEIN , Juergen Michael SCHANZER , Kay-Gunnar STUBENRAUCH , Pablo UMANA , Martina GEIGER , Eric SULLIVAN , Jigar PATEL
摘要： The present invention generally relates to novel protease-activatable T cell activating bispecific molecules and idiotype-specific polypeptides. The present invention also relates to polynucleotides encoding such protease-activatable T cell activating bispecific molecules and idiotype-specific polypeptides, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the protease-activatable T cell activating bispecific molecules and idiotype-specific polypeptides of the invention, and to methods of using these protease-activatable T cell activating bispecific molecules and idiotype-specific polypeptides in the treatment of disease.
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