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公开(公告)号：US20180031453A1
公开(公告)日：2018-02-01
申请号：US15730172
申请日：2017-10-11
申请人： Hologic, Inc.
IPC分类号： G01N1/30
CPC分类号： G01N1/30 , C12N1/066 , C12N15/1003 , C12N15/101 , C12Q1/6886 , C12Q1/689 , C12Q1/701
摘要： The present disclosure describes a method of treating a sample comprising cells with a process of partial lysing. Cells are exposed to a process such as bead beating that lyses some cells in the mixture. The process generates a resultant sample mixture that is suitable for both cell morphology screening and genetic screening. A first portion of the partially lysed sample can be mounted on a slide and observed for atypical cells and cytologic abnormalities. A second portion of the partially lysed sample can be screened for genetic markers known to correlate with a risk of cervical cancer. The method is particularly useful for cervical screening, where a combination of cytology and genetic screening present a more complete picture of cervical health. The disclosed method streamlines the diagnostic process for protocols that require both types of assays, without compromising screening accuracy.
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公开(公告)号：US09646376B2
公开(公告)日：2017-05-09
申请号：US14202665
申请日：2014-03-10
申请人： HOLOGIC, INC.
发明人： Howard B. Kaufman , Eileen Ludlow
CPC分类号： G06K9/00147 , G06F3/04842 , G06F3/04845 , G06F3/04855 , G06K9/00127 , G06T7/0012 , G06T2207/10056 , G06T2207/30004 , G06T2207/30024
摘要： Systems and methods of use to facilitate classification of cytological specimens are discussed. The system acquires or imports image data of a cytological specimen. The imported image data may include, or the system may otherwise perform an image analysis to identify one or more objects of interest in a respective specimen image dataset, including feature attributes for the identified objects. The system analyzes the feature attributes by predetermined criteria and/or optionally with user inputted criteria. The system includes an analysis tool that assists the user in identifying cytologically abnormal objects, if present in a particular specimen, by manipulating and viewing images of objects selected as a function of feature attributes. More generally, the analysis tool aides the user to find, extract, and display abnormal objects from within a large dataset of images and facilitates navigation through large amounts of image data and enables the efficient classification of the entire specimen.
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公开(公告)号：US20210072125A1
公开(公告)日：2021-03-11
申请号：US17091435
申请日：2020-11-06
申请人： Hologic, Inc.
摘要： The present disclosure describes a method of treating a sample comprising cells with a process of partial lysing. Cells are exposed to a process such as bead beating that lyses some cells in the mixture. The process generates a resultant sample mixture that is suitable for both cell morphology screening and genetic screening. A first portion of the partially lysed sample can be mounted on a slide and observed for atypical cells and cytologic abnormalities. A second portion of the partially lysed sample can be screened for genetic markers known to correlate with a risk of cervical cancer. Surprisingly the presence of beads in the mixture from the partial lysing process does not interfere with slide processing or cellular analysis. The method is particularly useful for cervical screening, where a combination of cytology and genetic screening present a more complete picture of cervical health. The disclosed method streamlines the diagnostic process for protocols that require both types of assays, without compromising screening accuracy.
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公开(公告)号：US09810610B2
公开(公告)日：2017-11-07
申请号：US14856611
申请日：2015-09-17
申请人： Hologic, Inc.
IPC分类号： G01N1/30
CPC分类号： G01N1/30 , C12N1/066 , C12N15/1003 , C12N15/101 , C12Q1/6886 , C12Q1/689 , C12Q1/701
摘要： The present disclosure describes a method of treating a sample comprising cells with a process of partial lysing. Cells are exposed to a process such as bead beating that lyses some cells in the mixture. The process generates a resultant sample mixture that is suitable for both cell morphology screening and genetic screening. A first portion of the partially lysed sample can be mounted on a slide and observed for atypical cells and cytologic abnormalities. A second portion of the partially lysed sample can be screened for genetic markers known to correlate with a risk of cervical cancer. The method is particularly useful for cervical screening, where a combination of cytology and genetic screening present a more complete picture of cervical health. The disclosed method streamlines the diagnostic process for protocols that require both types of assays, without compromising screening accuracy.
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公开(公告)号：US20160076980A1
公开(公告)日：2016-03-17
申请号：US14856611
申请日：2015-09-17
申请人： Hologic, Inc.
IPC分类号： G01N1/30
CPC分类号： G01N1/30 , C12N1/066 , C12N15/1003 , C12N15/101 , C12Q1/6886 , C12Q1/689 , C12Q1/701
摘要： The present disclosure describes a method of treating a sample comprising cells with a process of partial lysing. Cells are exposed to a process such as bead beating that lyses some cells in the mixture. The process generates a resultant sample mixture that is suitable for both cell morphology screening and genetic screening. A first portion of the partially lysed sample can be mounted on a slide and observed for atypical cells and cytologic abnormalities. A second portion of the partially lysed sample can be screened for genetic markers known to correlate with a risk of cervical cancer. Surprisingly the presence of beads in the mixture from the partial lysing process does not interfere with slide processing or cellular analysis. The method is particularly useful for cervical screening, where a combination of cytology and genetic screening present a more complete picture of cervical health. The disclosed method streamlines the diagnostic process for protocols that require both types of assays, without compromising screening accuracy.
摘要翻译： 本公开描述了以部分裂解的方法处理包含细胞的样品的方法。 将细胞暴露于诸如珠粒打浆的过程，其破坏混合物中的一些细胞。 该方法产生适合于细胞形态筛选和遗传筛选的所得样品混合物。 部分裂解的样品的第一部分可以安装在载玻片上并观察非典型细胞和细胞学异常。 部分裂解样品的第二部分可以筛选已知与子宫颈癌风险相关的遗传标记。 令人惊讶的是，来自部分裂解过程的混合物中存在珠不影响载玻片加工或细胞分析。 该方法对宫颈筛查特别有用，其中细胞学和遗传筛选的组合呈现出更完整的宫颈健康情况。 所公开的方法简化了需要两种类型的测定的方案的诊断过程，而不会影响筛选的准确性。
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公开(公告)号：US11719607B2
公开(公告)日：2023-08-08
申请号：US17091435
申请日：2020-11-06
申请人： Hologic, Inc.
CPC分类号： G01N1/30 , C12N1/066 , C12N15/101 , C12N15/1003 , C12Q1/689 , C12Q1/6886 , C12Q1/701
摘要： The present disclosure describes a method of treating a sample comprising cells with a process of partial lysing. Cells are exposed to a process such as bead beating that lyses some cells in the mixture. The process generates a resultant sample mixture that is suitable for both cell morphology screening and genetic screening.
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公开(公告)号：US10859475B2
公开(公告)日：2020-12-08
申请号：US15730172
申请日：2017-10-11
申请人： Hologic, Inc.
摘要： The present disclosure describes a method of treating a sample comprising cells with a process of partial lysing. Cells are exposed to a process such as bead beating that lyses some cells in the mixture. The process generates a resultant sample mixture that is suitable for both cell morphology screening and genetic screening. A first portion of the partially lysed sample can be mounted on a slide and observed for atypical cells and cytologic abnormalities. A second portion of the partially lysed sample can be screened for genetic markers known to correlate with a risk of cervical cancer. The method is particularly useful for cervical screening, where a combination of cytology and genetic screening present a more complete picture of cervical health. The disclosed method streamlines the diagnostic process for protocols that require both types of assays, without compromising screening accuracy.
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公开(公告)号：US20170140208A1
公开(公告)日：2017-05-18
申请号：US15419018
申请日：2017-01-30
申请人： HOLOGIC, INC.
发明人： Howard B. Kaufman , Eileen Ludlow
IPC分类号： G06K9/00 , G06F3/0485 , G06F3/0484 , G06T7/00
CPC分类号： G06K9/00147 , G06F3/04842 , G06F3/04845 , G06F3/04855 , G06K9/00127 , G06T7/0012 , G06T2207/10056 , G06T2207/30004 , G06T2207/30024
摘要： Systems and methods are directed to computer-assisted navigation of images of a cytological specimen, including the acts of analyzing a first image of the cytological specimen to identify a plurality of objects of interest within the cytological specimen, displaying a plurality of images each comprising one of the plurality of identified objects of interest within the cytological specimen and including a second image of at least one object of interest, and displaying, responsive to receiving a user selection of the second image of the at least one object of interest, a field of view of the at least one object of interest and neighboring objects of interest, wherein the second image of the at least one object of interest has a first magnification, and wherein the field of view of the at least one object of interest is displayed at a second magnification different than the first magnification.
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公开(公告)号：US20160074022A1
公开(公告)日：2016-03-17
申请号：US14856604
申请日：2015-09-17
申请人： Hologic, Inc.
发明人： Ryan Oliva , Steven Hecht , Howard B. Kaufman
CPC分类号： A61B10/0291 , A61B10/0096 , A61B2010/0216
摘要： The invention provides a device, system and method for sample collection wherein a sample can be separated into multiple portions of sample at the site of collection. The separation of portions of sample occurs by separating parts of the specimen collection device. Each of the separable parts contacting a portion of sample can be deposited into separate vessels. The device reduces the risk of sample contamination, because the separable parts can be separated by the action of a release mechanism that allows a user to separate the parts without touching or otherwise contacting the sample collecting region. The release mechanism may be trigger-activated to expel a separable part of the device.
摘要翻译： 本发明提供了用于样品收集的装置，系统和方法，其中样品可以在收集部位分离成多个样品部分。 通过分离样本收集装置的部分来分离部分样品。 接触一部分样品的每个可分离部分可以沉积到分开的容器中。 该装置降低了样品污染的风险，因为可分离的部件可以通过释放机构的作用分离，该释放机构允许使用者在不接触或以其他方式接触样品收集区域的情况下分离部件。 释放机构可以被触发激活以排出装置的可分离部分。
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公开(公告)号：US20140314300A1
公开(公告)日：2014-10-23
申请号：US14202665
申请日：2014-03-10
申请人： HOLOGIC, INC.
发明人： Howard B. Kaufman , Eileen Ludlow
CPC分类号： G06K9/00147 , G06F3/04842 , G06F3/04845 , G06F3/04855 , G06K9/00127 , G06T7/0012 , G06T2207/10056 , G06T2207/30004 , G06T2207/30024
摘要： Systems and methods of use to facilitate classification of cytological specimens are discussed. The system acquires or imports image data of a cytological specimen. The imported image data may include, or the system may otherwise perform an image analysis to identify one or more objects of interest in a respective specimen image dataset, including feature attributes for the identified objects. The system analyzes the feature attributes by predetermined criteria and/or optionally with user inputted criteria. The system includes an analysis tool that assists the user in identifying cytologically abnormal objects, if present in a particular specimen, by manipulating and viewing images of objects selected as a function of feature attributes. More generally, the analysis tool aides the user to find, extract, and display abnormal objects from within a large dataset of images and facilitates navigation through large amounts of image data and enables the efficient classification of the entire specimen.
摘要翻译： 讨论了用于促进细胞学标本分类的系统和方法。 系统获取或输入细胞学标本的图像数据。 导入的图像数据可以包括，或者系统还可以执行图像分析以识别相应样本图像数据集中的一个或多个感兴趣对象，包括所识别的对象的特征属性。 系统通过预定标准和/或可选地用用户输入的标准来分析特征属性。 该系统包括分析工具，其通过操纵和查看作为特征属性的函数选择的对象的图像来帮助用户识别细胞学异常物体（如果存在于特定样本中）。 更一般地，分析工具可以帮助用户从大量图像数据集中查找，提取和显示异常物体，并且便于通过大量图像数据进行导航，并且能够对整个样本进行有效的分类。
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