公开(公告)号：US08685956B2

公开(公告)日：2014-04-01

申请号：US13395736

申请日：2010-09-16

申请人： Hong-Hsing Liu ,  Gary Allen Peltz ,  Guochun Liao ,  Timothy Alan Garrow

发明人： Hong-Hsing Liu ,  Gary Allen Peltz ,  Guochun Liao ,  Timothy Alan Garrow

IPC分类号： A61K31/33

CPC分类号： A61K31/167 ,  A61K31/198 ,  A61K31/205 ,  A61K2300/00

摘要： The present disclosure relates generally to a pharmaceutical compositions and methods of reducing acetaminophen-induced liver toxicity. The disclosure includes pharmaceutical compositions including acetaminophen and one or more components selected from S-adenosylhomocysteine (SAH), S-methylmethionine (SMM), or a pharmaceutically acceptable salt thereof. The disclosure also relates to methods of reducing acetaminophen-induced liver toxicity in a subject by administering or co-administering one or more of S-adenosylhomocysteine (SAH), S-methylmethionine (SMM), or a pharmaceutically acceptable salt thereof, with acetaminophen to a subject.

摘要翻译： 本公开一般涉及减少对乙酰氨基酚诱导的肝毒性的药物组合物和方法。 本公开内容包括药物组合物，包括对乙酰氨基酚和选自S-腺苷高半胱氨酸（SAH），S-甲基甲硫氨酸（SMM）或其药学上可接受的盐的一种或多种组分。 本公开还涉及通过将一种或多种S-腺苷高半胱氨酸（SAH），S-甲基甲硫氨酸（SMM）或其药学上可接受的盐与对乙酰氨基酚给予或共同给予或共同给予或共同施用对乙酰氨基酚诱导的肝毒性的方法 课程。

公开(公告)号：US20120172324A1

公开(公告)日：2012-07-05

申请号：US13395736

申请日：2010-09-16

申请人： Hong-Hsing Liu ,  Gary Allen Peltz ,  Guochun Liao ,  Timothy Alan Garrow

发明人： Hong-Hsing Liu ,  Gary Allen Peltz ,  Guochun Liao ,  Timothy Alan Garrow

IPC分类号： A61K31/7076 ,  A61P29/00 ,  A61K31/167 ,  A61P1/16 ,  A61K31/205 ,  A61K31/198

CPC分类号： A61K31/167 ,  A61K31/198 ,  A61K31/205 ,  A61K2300/00

摘要： The present disclosure relates generally to a co-formulation or co-administration of acetaminophen with one or more chemicals that are metabolites or their derivatives in the methionine and glutathione biosynthesis pathways, for protection against acetaminophen-induced liver toxicity. The formulation may comprise acetaminophen and diet supplements such as S-methylmethionine (SMM). The present disclosure also encompasses methods of providing pain or fever relief with protection against acetaminophen-induced liver injury with the formulations described herein. Embodiments of the present disclosure also include co-formulation or co-administration of an agent and one or more other chemicals for reducing agent-induced liver toxicity via depletion of glutathione.

摘要翻译： 本公开一般涉及对乙酰氨基酚与一种或多种在甲硫氨酸和谷胱甘肽生物合成途径中作为代谢物或其衍生物的化学品的共同配制或共同给药，以防止对乙酰氨基酚诱导的肝毒性。 制剂可以包括对乙酰氨基酚和膳食补充剂，例如S-甲基甲硫氨酸（SMM）。 本公开还包括使用本文所述的制剂提供疼痛或发烧缓解的方法，以防止对乙酰氨基酚诱导的肝损伤。 本公开的实施方案还包括通过耗尽谷胱甘肽来共同配制或共同施用药剂和一种或多种其它用于还原剂诱导的肝毒性的化学品。