公开(公告)号：US08815913B2

公开(公告)日：2014-08-26

申请号：US12480675

申请日：2009-06-08

申请人： Huailin Sun ,  Jian Zhang ,  Qiuhua Liu ,  Lei Yu ,  Jiangyu Zhao

发明人： Huailin Sun ,  Jian Zhang ,  Qiuhua Liu ,  Lei Yu ,  Jiangyu Zhao

IPC分类号： A61K38/00 ,  C07K5/00 ,  C07K7/00 ,  C07K16/00 ,  C07K17/00 ,  C07K2/00 ,  C07K4/00 ,  C07K14/00 ,  C07K1/08 ,  C07K1/02

CPC分类号： C07K1/088 ,  C07K1/02

摘要： Polypeptides of formula (I): wherein R1 and R2 are substituents independently selected from substituted and un-substituted alkyl groups and substituted and un-substituted aryl groups, and n is an integer greater than or equal to 2. Synthesis methods are also provided that do not use amino acids as starting materials, but instead employ imines and carbon monoxide as monomers that undergo transition metal-catalyzed alternating copolymerization to directly provide polypeptides using an acylcobalt catalyst with the following structural formula: wherein R is selected from the group consisting of alkyl, phenyl, and substituted phenyl groups.

摘要翻译： 式（I）的多肽：其中R 1和R 2是独立地选自取代和未取代的烷基和取代和未取代的芳基的取代基，n是大于或等于2的整数。还提供了合成方法 不要使用氨基酸作为原料，而是使用亚胺和一氧化碳作为进行过渡金属催化的交替共聚的单体，以使用具有以下结构式的酰基钴催化剂直接提供多肽：其中R选自烷基 ，苯基和取代的苯基。