公开(公告)号：US20070292866A1

公开(公告)日：2007-12-20

申请号：US11634755

申请日：2006-12-06

申请人： Huajan Wang ,  Anthony Anisowicz ,  Richard Del Mastro ,  Hui Huang ,  Sergey Mamaev

发明人： Huajan Wang ,  Anthony Anisowicz ,  Richard Del Mastro ,  Hui Huang ,  Sergey Mamaev

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6844 ,  C12Q2521/331

摘要： This invention relates to methodologies that detect global changes in the methylation of human genomic DNA as well as changes in methylation in specific regions of the human genome. The methodologies have utility in the diagnosis, prognosis and monitoring of therapeutic treatment for any human disease. Further, the invention relates to methodologies that can detect global changes in the methylation of human genomic DNA that is a consequence of diet and/or dietary supplements. The invention also relates to identifying novel DNA methylation biomarkers that are associated with human disease.

摘要翻译： 本发明涉及检测人类基因组DNA甲基化的全球变化以及人类基因组特定区域甲基化变化的方法。 该方法可用于任何人类疾病的治疗性治疗的诊断，预后和监测。 此外，本发明涉及可以检测作为饮食和/或膳食补充剂的结果的人类基因组DNA甲基化的全球变化的方法。 本发明还涉及鉴定与人类疾病相关的新的DNA甲基化生物标志物。