公开(公告)号：US20250136712A1

公开(公告)日：2025-05-01

申请号：US18683155

申请日：2022-08-12

Applicant: Hummingbird Bioscience Pte. Ltd.

Inventor： Jerome Douglas Boyd-Kirkup ,  Shreya kar ,  Konrad Paszkiewicz ,  Dipti Thakkar ,  Piers Ingram

IPC: C07K16/32 ,  A61K39/00 ,  A61P35/00 ,  C12Q1/6886

Abstract: The present disclosure provides the use of an antigen-binding molecule that binds to HERS for the treatment or prevention of cancers comprising (i) at least one gene encoding a positive regulator of HERS-mediated signalling that does not comprise an activating mutation; or (ii) at least one gene encoding a negative regulator of HERS-mediated signalling that does not comprise an inactivating mutation.