公开(公告)号：US20240238439A1

公开(公告)日：2024-07-18

申请号：US18403476

申请日：2024-01-03

Applicant: Hummingbird Bioscience Pte. Ltd.

Inventor： Suhail Ahmed Kabeer Rasheed ,  Dipti Thakkar ,  Shalini Paliwal ,  Wen Jie Chin ,  Akshaya Bansal ,  Benjamin Ayers ,  Cheng Theng Ng ,  Brendon Hanson ,  Piers Ingram ,  Jerome Boyd-Kirkup

IPC: A61K47/68 ,  A61P35/00 ,  G01N33/574

CPC classification number: A61K47/6851 ,  A61K47/68037 ,  A61K47/6889 ,  A61P35/00 ,  G01N33/5748 ,  G01N2333/82

Abstract: Methods of treating cancer are provided, as well as compositions including an antigen-binding molecule that binds to HER3, comprising (i) a HER3-binding moiety, and (ii) a linker-payload moiety comprising exatecan or a derivative thereof.

公开(公告)号：US20240158538A1

公开(公告)日：2024-05-16

申请号：US18518192

申请日：2023-11-22

Applicant: Hummingbird Bioscience Pte. Ltd.

Inventor： Jerome Boyd-Kirkup ,  Piers Ingram ,  Dipti Thakkar ,  Zhihao Wu ,  Konrad Paszkiewicz ,  Vicente Sancenon ,  Siyu Guan

IPC: C07K16/46

CPC classification number: C07K16/464 ,  C07K16/468 ,  C07K2317/522 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/72

Abstract: VISTA antigen-binding molecules are disclosed. Also disclosed are nucleic acids and expression vectors encoding, compositions comprising, and methods using, the VISTA antigen-binding molecules.

公开(公告)号：US20230374147A1

公开(公告)日：2023-11-23

申请号：US18034867

申请日：2021-11-02

Applicant: Hummingbird Bioscience Pte. Ltd.

Inventor： Fabien Decaillot ,  Jerome Douglas Boyd-Kirkup ,  Dipti Thakkar ,  Piers Ingram ,  Konrad Paszkiewicz ,  Chia-Yi Liu

IPC: C07K16/28 ,  A61P35/00

CPC classification number: C07K16/2878 ,  C07K16/2803 ,  C07K16/2809 ,  A61P35/00 ,  A61K2039/505

Abstract: BCMA/TACI antigen-binding molecules are disclosed. Also disclosed are nucleic acids and expression vectors encoding, compositions comprising, and methods using, the BCMA/TACI antigen-binding molecules.

公开(公告)号：US20190300624A1

公开(公告)日：2019-10-03

申请号：US16170370

申请日：2018-10-25

Applicant: Hummingbird Bioscience Pte. Ltd.

Inventor： Jerome Douglas Boyd-Kirkup ,  Siyu Guan ,  Piers Ingram ,  Konrad Paszkiewicz ,  Vicente Sancenon ,  Dipti Thakkar ,  Zhihao Wu

IPC: C07K16/32 ,  A61P35/00 ,  C07K14/725 ,  C12N15/62 ,  C12N15/85

Abstract: HER3 antigen-binding molecules are disclosed. Also disclosed are nucleic acids and expression vectors encoding, compositions comprising, and methods using, the HER3 antigen-binding molecules.

公开(公告)号：US20240092937A1

公开(公告)日：2024-03-21

申请号：US18458997

申请日：2023-08-30

Applicant: Hummingbird Bioscience Pte. Ltd.

Inventor： Jerome Douglas Boyd-Kirkup ,  Piers Ingram ,  Dipti Thakkar ,  Zhihao Wu ,  Konrad Paszkiewicz ,  Vicente Sancenon ,  Siyu Guan

IPC: C07K16/32 ,  A61P35/00 ,  C07K14/725 ,  C07K16/28 ,  C12N15/62 ,  C12N15/85

CPC classification number: C07K16/32 ,  A61P35/00 ,  C07K14/7051 ,  C07K16/28 ,  C12N15/62 ,  C12N15/85 ,  A61K2039/505

Abstract: HER3 antigen-binding molecules are disclosed. Also disclosed are nucleic acids and expression vectors encoding, compositions comprising, and methods using, the HER3 antigen-binding molecules.

公开(公告)号：US20190300610A1

公开(公告)日：2019-10-03

申请号：US16180949

申请日：2018-11-05

Applicant: Hummingbird Bioscience Pte. Ltd. ,  Hummingbird Bioscience Holdings Pte. Ltd.

Inventor： Jerome Douglas Boyd-Kirkup ,  Piers Ingram ,  Dipti Thakkar ,  Zhihao Wu ,  Konrad Paszkiewicz ,  Vicente Sancenon ,  Siyu Guan

IPC: C07K16/28 ,  A61P35/00 ,  A61P35/02 ,  A61P35/04

Abstract: V-type immunoglobulin domain-containing suppressor of T-cell activation (VISTA) antigen-binding molecules are disclosed. Also disclosed are nucleic acids and expression vectors encoding, compositions comprising, and methods using, the VISTA antigen-binding molecules.

公开(公告)号：US20250122303A1

公开(公告)日：2025-04-17

申请号：US18688576

申请日：2022-09-02

Applicant: Hummingbird Bioscience Pte. Ltd. ,  Cancer Research Technology Limited

Inventor： Nigel Westwood ,  Harriet Walters ,  Gavin Halbert ,  Jennifer L. Craigen ,  Siyu Guan ,  Jerome Boyd-Kirkup ,  Piers Ingram ,  Dipti Thakkar

IPC: C07K16/32 ,  A61K31/4166 ,  A61K39/00 ,  A61P35/00

Abstract: The present disclosure provides antigen-binding molecules that bind to HER3 for the treatment or prevention of cancers, compositions comprising said molecules, and therapeutic and prophylactic methods using said molecules.

公开(公告)号：US11780933B2

公开(公告)日：2023-10-10

申请号：US16805620

申请日：2020-02-28

Applicant: Hummingbird Bioscience Pte. Ltd.

Inventor： Jerome Douglas Boyd-Kirkup ,  Piers Ingram ,  Dipti Thakkar ,  Zhihao Wu ,  Konrad Paszkiewicz ,  Vicente Sancenon ,  Siyu Guan

IPC: A61K39/395 ,  C07K16/32 ,  C07K16/28 ,  A61P35/00 ,  C07K14/725 ,  C12N15/62 ,  C12N15/85 ,  A61K39/00

CPC classification number: C07K16/32 ,  A61P35/00 ,  C07K14/7051 ,  C07K16/28 ,  C12N15/62 ,  C12N15/85 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/522 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/72 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/92

Abstract: HER3 antigen-binding molecules are disclosed. Also disclosed are nucleic acids and expression vectors encoding, compositions comprising, and methods using, the HER3 antigen-binding molecules.

公开(公告)号：US11685789B2

公开(公告)日：2023-06-27

申请号：US17847020

申请日：2022-06-22

Applicant: Hummingbird Bioscience Pte. Ltd.

Inventor： Jerome Boyd-Kirkup ,  Dipti Thakkar ,  Piers Ingram ,  Zhihao Wu ,  Konrad Paszkiewicz ,  Peter Brauer ,  Siyu Guan

IPC: C07K16/28 ,  A61K39/395 ,  A61P35/00 ,  C12N15/09 ,  C12N15/62 ,  C07H21/00 ,  A61K39/00 ,  C12N15/11

CPC classification number: C07K16/2896 ,  A61K39/39558 ,  A61P35/00 ,  C07H21/00 ,  C07K16/2803 ,  C12N15/09 ,  C12N15/62 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92 ,  C12N15/11

Abstract: CD47 antigen-binding molecules are disclosed. Also disclosed are nucleic acids and expression vectors encoding, compositions comprising, and methods using, the CD47 antigen-binding molecules.

公开(公告)号：US20250136712A1

公开(公告)日：2025-05-01

申请号：US18683155

申请日：2022-08-12

Applicant: Hummingbird Bioscience Pte. Ltd.

Inventor： Jerome Douglas Boyd-Kirkup ,  Shreya kar ,  Konrad Paszkiewicz ,  Dipti Thakkar ,  Piers Ingram

IPC: C07K16/32 ,  A61K39/00 ,  A61P35/00 ,  C12Q1/6886

Abstract: The present disclosure provides the use of an antigen-binding molecule that binds to HERS for the treatment or prevention of cancers comprising (i) at least one gene encoding a positive regulator of HERS-mediated signalling that does not comprise an activating mutation; or (ii) at least one gene encoding a negative regulator of HERS-mediated signalling that does not comprise an inactivating mutation.